Conserved surface-exposed K/R-X-K/R motifs and net positive charge on poxvirus complement control proteins serve as putative heparin binding sites and contribute to inhibition of molecular interactions with human endothelial cells: A novel mechanism for evasion of host defense

Journal of Virology

Volumn 74, Issue 12, 2000, Pages 5659-5666

  Smith, Scott A ^a   Mullin, Nick P ^a   Parkinson, John ^b   Shchelkunov, Sergei N ^c   Totmenin, Alexei V ^c   Loparev, V N ^d   Srisatjaluk, Ratchapin ^a   Reynolds, David N ^a   Keeling, Kristen L ^a   Justus, David E ^a   Barlow, Paul N ^b   Kotwal, Girish J ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c STATE RESEARCH CENTER OF VIROLOGY AND BIOTECHNOLOGY VECTOR   (Russian Federation)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN BINDING PROTEIN; UNCLASSIFIED DRUG; VACCINIA VIRUS COMPLEMENT CONTROL PROTEIN;

ARTICLE; BINDING SITE; COMPLEMENT ALTERNATIVE PATHWAY; ENDOTHELIUM CELL; GENETIC ENGINEERING; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOLECULAR MODEL; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; VIRUS CELL INTERACTION;

EID: 0034037120     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.12.5659-5666.2000     Document Type: Article

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