Regulation of TNFα and TGFβ-1 gene transcription by HIV-1 Tat in CNS cells

Journal of Neuroimmunology

Volumn 87, Issue 1-2, 1998, Pages 33-42

  Sawaya, Bassel E ^a   Thatikunta, Prakash ^a   Denisova, Lyudmilla ^a   Brady, John ^b   Khalili, Kamel ^a   Amini, Shohreh ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CNS cells; HIV Tat; TNF and TGF gene transcription

Indexed keywords

TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BRAIN DISEASE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; BRAIN; CELL CULTURE; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; LEUKEMIA CELL LINE; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; TRANSACTIVATION;

BRAIN; GENE PRODUCTS, TAT; HIV-1; HUMANS; JURKAT CELLS; MUTATION; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032105477     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00044-7     Document Type: Article

References (69)

1. Arya, S.K., Guo, C., Josephs, S.F., Wong-Staal, F., 1985. Transactivator gene of human T-lymphotropic virus type III. Science 229, 69-75.
2. Ausubel, F., Brent, R., Kingston, R., Moore, D., Seidman, J., Smith, J., Struhl, K., 1996. In: Chanda, V., (Ed.), Current Protocols in Molecular Biology, Wiley.
3. Bagetta, G., Corasiniti, M.T., Aloe, L., Berliocchi, L., Costa, N., Finazzai-Agro, A., Nistico, G., 1996. Intracerebral infection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat. Proc. Natl. Acad. Sci. U.S.A. 93, 928-933.
4. Benos, D.J., Han, B.H., Bubien, J.K., Ghosh, S.K., Mashburn, N.A., Chaikin, M.A., Shaw, G.M., Benveniste, E.N., 1994. Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex. Proc. Natl. Acad. Sci. U.S.A. 91, 494-498.
5. Benveniste, E.N., Benos, D.J., 1995. TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function. FASEB J. 9, 1577-1584.
6. Braddock, M., Chambers, A., Wilson, W., Ensouf, M.P., Adams, S.E., Kingsman, A.J., Kingsman, S.M., 1989. HIV-1 Tat 'activates' presynthesized RNA in the nucleus. Cell 58, 269-279.
7. Brenneman, D.E., Westbrook, G.L., Fitzgerald, S.P., Ennist, D.L., Elkins, K.L., Ruff, M.R., Pert, C.B., 1988. Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Nature 335, 639-642.
8. Calnan, B.J., Biancalana, S., Hudson, D., Frankel, A.D., 1991a. Analysis of arginine-rich peptides from HIV Tat protein reveals unusual features of RNA-protein recognition. Genes Dev. 5, 201-210.
9. Calnan, B.J., Tidor, B., Biancalana, S., Hudson, D., Frankel, A.D., 1991b. Arginine-mediated RNA recognition: the arginine fork. Science 252, 1167-1171.
10. Chen, P., Mayne, M.M., Power, C., Nath, A., 1997. The Tat protein of HIV-1 induces tumor necrosis factor-α production. J. Biol. Chem. 272, 22385-22388.
11. Chomczynski, P., Sacchi, N., 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
12. Chowdhury, M., Taylor, J.P., Tada, H., Rappaport, J., Amini, S., Wong-Staal, F., Khalili, K., 1990. Regulation of the human neurotropic virus promoter by JCV T-antigen and HIV-1 tat protein. Oncogene 5, 1737-1742.
13. Conant, K., Ma, M., Nath, A., Major, E.O., 1996. Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes. J. Virol. 70, 1384-1389.
14. Cullen, B.R., 1996. Transactivation of human immunodeficiency virus occurs via a bimodal mechanism. Cell 46, 973-982.
15. Cupp, C., Taylor, J.P., Khalili, K., Amini, S., 1993. Evidence for stimulation of the transforming growth factor β1 promoter by HIV-1 Tat in cells derived from CNS. Oncogene 8, 2231-2236.
16. Dawson, V.L., Dawson, T.M., Uhl, G.R., Snyder, S.H., 1993. Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical culture. Proc. Natl. Acad. Sci. U.S.A. 90, 3256-3259.
17. Derse, D., Carvalho, M., Carroll, R., Peterlin, B.M., 1991. A minimal lentivirus Tat. J. Virol. 65, 7012-7015.
18. Derynck, R., Jarrett, J.A., Chen, E.Y., Eaton, D.H., Bell, J.R., Assoian, R.K., Roberts, A.B., Sporn, M.B., Goeddel, D.V., 1985. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature 316, 701-705.
19. Dreyer, E.V., Kaiser, P.K., Offermann, J.T., Lipton, S.A., 1990. HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 248, 364-367.
20. Duan, L.-X., Pomerantz, R.J., 1994. Elimination of endogenous aberrant kappa chain transcripts from hybridomas by specific ribozyme cleavage: utility in genetic therapies of HIV-1 infections. Nucleic Acid Res. 22, 5433-5438.
21. Duan, L.-X., Zhu, M., Bagasra, O., Pomerantz, R.J., 1995. Intracellular immunization against HIV-1 infection of human T-lymphocytes: utility of anti-Rev single chain variable fragments. Hum. Gene Ther. 6, 1561-1563.
22. Eddleston, M., DeLa Torre, J.C., Xu, J.-Y., Dorfman, N., Notkins, A., Zolla-Pazner, S., Oldstone, M.B.A., 1993. Molecular mimicry accompanying HIV-1 infection: human monoclonal antibodies that bind to gp41 and to astroctyes. AIDS Res. Hum. Retroviruses 9, 939-944.
23. Ensoli, B., Buonaguro, L., Barillari, G., Fiuorelli, V., Gendelman, R., Morgan, R.A., Wingfield, P., Gallo, R.C., 1993. Release, uptake, and effects of extracellular human immunodeficiency virus type 1 tat protein on cell growth and viral transactivation. J. Virol. 67, 277-287.
24. Fine, S.M., Angel, R.A., Perry, S.W., Epstein, L.G., Rothstein, J.D., Dewhurst, S., Gelbard, H.A., 1996. Tumor necrosis factor α inhibits glutamate uptake by primary human astrocytes: Implications for pathogenesis of HIV-1 dementia. J. Biol. Chem. 271, 15303-15306.
25. Fragioni, J.V., Neel, B.G., 1993. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal. Biochem. 210, 179-187.
26. Gallo, P., Frei, K., Rordorf, C., Lazdins, J., Tavolato, B., Fontana, A., 1989. Human immunodeficiency virus type 1 (HIV) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. J. Neuroimmunol. 23, 109-116.
27. Garcia, J.A., Harrich, D., Rearson, L., Misuyasu, R., Gaynor, R., 1988. Functional domains required for tat-induced transcriptional activation of the HIV-1 long terminal repeat. EMBO J. 7, 3143-3147.
28. Gelbard, H.A., Dzenko, K.A., DiLoreto, D., delCerro, C., delCerro, M., Epstein, L.G., 1993. Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis. Dev. Neurosci. 15, 417-422.
29. Genis, P., Jett, M., Berton, E.W., 1992. Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J. Exp. Med. 176, 1703-1718.
30. Giulian, D., Vaca, K., Noonan, C.A., 1990. Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 250, 1593-1596.
31. Giulian, D., Wendt, E., Vaca, K., Noonan, C.A., 1993. The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes. Proc. Natl. Acad. Sci. U.S.A. 90, 2769-2773.
32. Gorman, C.M., Moffat, L.F., Howard, B.H., 1982. Recombinant genomes which express chloramphenicol acetyltransferases in mammalian cells. Mol. Cell. Biol. 2, 1044-1051.
33. Graham, F.L., Van der Eb, A.J., 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
34. Green, M., Ishino, M., Lowenstein, P.M., 1989. Mutational analyis of HIV-1 Tat minimal domain peptides: identification of trans-dominant mutants that suppress HIV-LTR driven gene expression. Cell 58, 215-223.
35. Grimaldi, L.M.E., Martino, G.V., Franciotta, D.M., Brustia, R., Castagna, A., Pristera, R., 1991. Elevated alpha-tumor necrosis factor levels in spinal fluid from HIV-1 infected patients with central nervous system involvement. Ann. Neurol. 29, 21-25.
36. Jones, K.A., 1997. Taking a new TAK on Tat transactivation. Genes Dev. 11, 2593-2599.
37. Kashanchi, F., Sadaie, M.R., Brady, J.N., 1997. Inhibition of HIV-1 transcription and virus replication using soluble Tat peptide analogs. Virology 227, 431-438.
38. Krachmarov, C.P., Chepenik, L.G., Barr, S.M., Khalili, K., Johnson, E.M., 1996. Association of the HIV-1 Tat protein with human cellular protein, Pur a, enhances binding of Pur a to the JC virus Tat-responsive transcriptional control element. Proc. Natl. Acad. Sci. U.S.A. 93, 14112-14117.
39. Kuppuswamy, M., Subramanian, T., Srinivasan, A., Chinnadurai, G., 1989. Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysis. Nucleic Acids Res. 17, 3551-3561.
40. Levi, G., Patrizio, A., Bernardo, A., Petrucci, T.C., Agresti, C., 1993. Human immunodeficiency virus coat protein gp120 inhibits the β adrenergic regulation of astroglial and microglial functions. Proc. Natl. Acad. Sci. U.S.A., 1541-1545.
41. Ma, M., Nath, A., 1997. Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. J. Virol. 71, 2495-2499.
42. Merrill, J.E., Koyanagi, Y., Zach, J., Thomas, L., Martin, F., Chen, I.S., 1992. Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1. J. Virol. 66, 2217-2225.
43. Perrella, O., Carrieri, P.B., Guarnaccia, D., Soscia, M., 1992. Cerebrospinal fluid cytokines and AIDS dementia complex. J. Neurol. 239, 387-388.
44. Price, R.W., 1996. Neurological complications of HIV infection. Lancet 348, 445-452.
45. Pulliam, L., West, D., Haigwood, N., Swanson, R.A., 1993. HIV-1 envelop gp120 alters astrocytes in human brain cultures. AIDS Res. Hum. Retroviruses 9, 439-444.
46. Rappaport, J., Lee, S.J., Khalili, K., Wong-Staal, F., 1989. The acidic amino-terminal region of HIV-1 tat protein constitutes an essential activating domain. New Biol. 1, 101-110.
47. Rasty, S., Thatikunta, P., Gordon, J., Khalili, K., Amini, S., Glorioso, J., 1996. Human immunodeficiency virus tat gene transfer to the murine central nervous system using a replication-defective herpes simplex virus vector stimulates transforming growth factor beta 1 gene expression. Proc. Natl. Acad. Sci. U.S.A. 93, 6073-6078.
48. Rhim, H., Echetebu, C.O., Hermann, C.H., Rice, A.P., 1994. Wild-type and mutant HIV-I and HIV-2 Tat proteins expressed in Escherichia coli as fusions with glutathione S-transferase. J. AIDS 7, 1116-1121.
49. Rice, A.P., Carlotti, F., 1990. Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein. J. Virol. 64, 1864-1868.
50. Sabatier, J.-M., Vives, E., Mabrouk, K., Benjouad, A., Rochat, H., Duval, A., Hue, B., Bahraoui, E., 1991. Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1. J. Virol. 65, 961-967.
51. Sadaie, M.R., Benter, T., Wong-Staal, F., 1988. Site-directed mutagenesis of two trans-regulatory genes (tatIII, trs) of HIV. Science 239, 910-913.
52. Seigel, L.J., Ratner, L., Josephs, S.F., Derse, D., Feinberg, M., Reyes, G.A., O'Brien, S.J., Wong-Staal, F., 1986. Trans-activation induced by human T-lymphotropic virus type III (HTLV-III) maps to a viral sequence encoding 58 amino acids and lacks tissue specificity. Virology 148, 226-231.
53. Sodroski, J., Rosen, C., Wong-Staal, F., Salahuddin, S., Popovic, M., Arya, S., Gallo, R.C., Haseltine, W.A., 1985. Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science 227, 171-173.
54. Tardieu, M., Hery, S., Peudenier, O., Boespflug, O., Montagnier, L., 1992. Human immunodeficiency virus type 1-infected monocytic cells can destroy human neural cells after cell-to-cell adhesion. Ann. Neurol. 32, 11-17.
55. Taylor, J.P., Diaz, A., Chowdhury, M., Khalili, K., Jimenez, S., Amini, S., 1992a. Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells. Proc. Natl. Acad. Sci. U.S.A. 89, 9617-9621.
56. Taylor, J.P., Pomerantz, R.J., Bagasra, O., Chowdhury, M., Rappaport, J., Khalili, K., Amini, S., 1992b. TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation. EMBO J. 11, 3395-3403.
57. Taylor, J.P., Kundu, M., Khalili, K., 1993. TAR-independent activation of HIV-1 requires the activation domain but not the RNA-binding domain of Tat. Virology 195, 780-785.
58. Taylor, J.P., Pomerantz, R.J., Raj, G.V., Kashanchi, F., Brady, J.N., Amini, S., Khalili, K., 1994. Central nervous system-derived cells express a kappa B-binding activity that enhances human immunodeficiency virus type 1 transcription in vitro and facilitates TAR-independent transactivation by Tat. J. Virol. 68, 3971-3981.
59. Thatikunta, P., Sawaya, B.E., Denisova, L., Cole, C., Yusibova, G., Johnson, E.M., Khalili, K., Amini, S., 1997. Identification of a cellular protein that binds to Tat-responsive element of TGFβ-1 promoter in glial cells. J. Cell. Biochem. 67, 466-477.
60. Toggas, S.M., Masliah, E., Rockenstein, E.M., Rali, G.F., Abraham, C.R., Mucke, L., 1994. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367, 188-194.
61. Venkatesh, L.K., Arens, M.Q., Subramanian, T., Chinnadurai, G., 1990. Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector. Proc. Natl. Acad. Sci. U.S.A. 87, 8746-8750.
62. Wahl, S.M., Allen, J.B., McCartney-Francis, N., Morganti-Kossmann, M.C., Kossmann, T., Ellingworth, L., Mai, U.E., Mergrnhagen, S.E., Ornstein, J.M., 1991. Macrophage and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome. J. Exp. Med. 173, 981-991.
63. Weeks, K.M., Ampe, C., Schultz, S.C., Steitz, T.A., Crothers, D.M., 1990. Fragments of the HIV-1 Tat protein specifically bind TAR RNA. Science 249, 1281-1285.
64. Wesselingh, S.L., Power, C., Glass, J.D., Tyor, W.R., McArthur, J.C., Farber, J.M., Griffin, J.W., Griffin, D.E., 1993. Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann. Neurol. 33, 576-582.
65. Wilt, S.G., Milward, E., Zhou, J.M., Nagasato, K., Patton, H., Rusten, R., Griffin, D.E., O'Connor, M., Dubois-Dalcq, M., 1995. In vitro evidence for a dual role of tumor necrosis factor-alpha in human immunodeficiency virus type 1 encephalopathy. Ann. Neurol. 37, 381-394.
66. Wyss-Coray, T., Masliah, E., Toggas, S.M., Rockenstein, E.M., Brooker, M.J., Lee, H.S., Mucke, L., 1996. Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis. J. Clin. Invest. 97, 789-798.
67. Yang, L., Morris, G.F., Lockyer, J.M., Lu, M., Wang, Z., Morris, C.B., 1997a. Distinct transcriptional pathways of TAR-dependent and TAR-independent human immunodeficiency virus type 1 transactivation by Tat. Virology 235, 48-64.
68. Yang, X., Gold, M.O., Tang, D.N., Lewis, D.E., Aguilar-Cordova, E., Rice, A.P., a nd Herrmann, C.H., 1997b. TAK, and HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. Proc. Natl. Acad. Sci. U.S.A. 94, 12331-12336.
69. Zhu, Y., Pe'ery, T., Peng, J., Ramanathan, Y., Marshall, N., Marshall, T., Amendt, B., Mathews, M.B., Price, D.H., 1997. Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro. Genes Dev. 11, 2622-2632.