Muscle activity and muscle agrin regulate the organization of cytoskeletal proteins and attached acetylcholine receptor (AChR) aggregates in skeletal muscle fibers

Journal of Cell Biology

Volumn 153, Issue 7, 2001, Pages 1453-1463

  Bezakova, Gabriela ^a,b   Lømo, Terje ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Acetylcholine receptor; Agrin; Costameres; Cytoskeleton; Electrical activity

Indexed keywords

AGRIN; CHOLINERGIC RECEPTOR; CYTOSKELETON PROTEIN; DYSTROGLYCAN; DYSTROPHIN; LAMININ; RAPSYN; RECOMBINANT PROTEIN; SYNTROPHIN; UTROPHIN;

ANIMAL TISSUE; ARTICLE; CAPPING PHENOMENON; CONCENTRATION RESPONSE; COSTAMERE; CYTOSKELETON; ELECTRIC ACTIVITY; ELECTROSTIMULATION; MALE; MUSCLE CONTRACTION; MUSCLE DENERVATION; MUSCLE INNERVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SKELETAL MUSCLE;

AGRIN; ANIMALS; CYTOSKELETAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DYSTROGLYCANS; DYSTROPHIN; DYSTROPHIN-ASSOCIATED PROTEINS; ELECTRIC STIMULATION; HUMANS; LAMININ; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MUSCLE CONTRACTION; MUSCLE DENERVATION; MUSCLE FIBERS; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEIN ISOFORMS; RATS; RATS, WISTAR; RECEPTOR AGGREGATION; RECEPTORS, CHOLINERGIC; RECOMBINANT PROTEINS; UTROPHIN;

ANIMALIA;

EID: 0035954431     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.7.1453     Document Type: Article

References (45)

1. Degradation of two AChR populations at rat neuromuscular junctions: Regulation by electrical stimulation
2. Effects of purified recombinant neural and muscle agrin on skeletal muscle fibers in vivo
3. Remodeling of the cytoskeletal lattice in denervated skeletal muscle
4. The laminin α2 expressed by dystrophic dy(2J) mice is defective in its ability to form polymers
5. Laminin polymerization induces a receptor-cytoskeleton network
6. γ actin, spectrin, and intermediate filament proteins colocalize with vinculin at costameres, myofibril-to-sarcolemma attachment sites
7. Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex
8. An aminoterminal extension is required for the secretion of chick agrin and its binding to extracellular matrix
9. Agrin binds to the nerve-muscle basal lamina via laminin
10. β-sarcoglycan: Genomic analysis and identification of a novel missense mutation in the LGMD2E Amish isolate
11. Progressive muscular dystrophy in α-sarcoglycan-deficient mice
12. Dystrophin and the membrane skeleton
13. Dystrophin-associated glycoproteins: Their possible roles in the pathogenesis of Duchenne muscular dystrophy
14. + channels and ankyrin in neuromuscular junctions is complementary to that of acetylcholine receptors and the 43 kd protein
15. Regulation of turn-over and number of acetylcholine receptors at neuromuscular junctions
16. Dystroglycan-a, a dystrophin-associated glycoprotein, is a functional agrin receptor
17. Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins
18. Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor
19. Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue
20. Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane
21. Dystroglycan inside and out
22. Agrin binding to α-dystroglycan. Domains of agrin necessary to induce acetylcholine receptor clustering are overlapping but not identical to the α-dystroglycan-binding region
23. Tensegrity: The architectural basis of cellular mechanotransduction
24. Identification and characterization of the dystrophin anchoring site on β-dystroglycan
25. Neural regulation of α-dystroglycan biosynthesis and glycosylation in skeletal muscle
26. Muscle agrin: Neural regulation and localization at nerve-induced acetylcholine receptor clusters
27. Muscle-derived agrin in cultured myotubes: Expression in the basal lamina and at induced acetylcholine receptor clusters
28. The agrin hypothesis
29. Transmission of forces within mammalian skeletal muscles
30. Differential membrane localization and intermolecular associations of α-dystrobrevin isoforms in skeletal muscle
31. Differential expression of agrin in renal basement membranes as revealed by domain-specific antibodies
32. Golgi complex, endoplasmic reticulum exit sites, and microtubules in skeletal muscle fibers are organized by patterned activity
33. The functions of laminins: Lessons from in vivo studies
34. The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin
35. Activity-dependent accumulation of basal lamina by cultured rat myotubes
36. Development of the vertebrate neuromuscular junction
37. Molecular diversity of myofibrillar proteins: Gene regulation and functional significance
38. Muscular dystrophies and the dystrophinglycoprotein complex
39. Direct visualization of the dystrophin network on skeletal muscle fiber membrane
40. Animal models for muscular dystrophy show different patterns of sarcolemmal disruption
41. Lateral transmission of tension in frog myofibers: A myofibrillar network and transverse cytoskeletal connections are possible transmitters
42. Dystroglycan binds nerve and muscle agrin
43. Extensive but coordinated reorganization of the membrane skeleton in myofibers of dystrophic (mdx) mice
44. Membrane skeleton of innervated and denervated fast- and slow-twitch muscle
45. Acetylcholine receptors in innervated muscles of dystrophic mdx mice degrade as after denervation