Novel regulation of cyclooxygenase-2 expression and prostaglandin E2 production by IFN-γ in human macrophages

Journal of Immunology

Volumn 161, Issue 5, 1998, Pages 2441-2448

  Barrios Rodiles, Miriam ^a   Chadee, Kris ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GAMMA INTERFERON; MESSENGER RNA; PROSTAGLANDIN E2;

ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MACROPHAGE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DOWN-REGULATION; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HUMANS; IMMUNIZATION; INTERFERON TYPE II; INTERLEUKIN-1; ISOENZYMES; KINETICS; MACROPHAGES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN SYNTHESIS INHIBITORS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0032167604     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. DeWitt, D. L. 1991. Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim. Biophys. Ada 1083:121.
2. Vane, J. R., J. A. Mitchell, I. Appleton, A. Tomlinson, D. Bishop-Bailey, J. Croxtal, and D. A. Willoughby. 1994. Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation. Proc. Natl. Acad. Sci. USA 91:2046.
3. 2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J. Immunol. 150:5321.
4. Romagnani, S. 1997. The Th1/Th2 paradigm. Immunol. Today 18:263.
5. Figuereido, F., T. J. Koerner, and D. O. Adams. 1989. Molecular mechanisms regulating the expression of class II histocompatibility molecules on macrophages: effect of inductive and suppresive signals on gene transcription. J. Immunol. 143:3781.
6. 2 regulates macrophage-derived tumor necrosis factor gene expression. J. Biol. Chem. 263:5380.
7. Smith, W. L. and L. J. Marnett. 1991. Prostaglandin endoperoxide synthase: structure and catalysis. Biochim. Biophys. Acta 1083:1.
8. O'Banion, K. M., V. D. Winn, and D. A. Young. 1992. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. USA 89:4888.
9. Ristimakii, A., S. Garfinkel, J. Wessendorf, T. Maciag, and T. Hla. 1994. Induction of eyclooxygenase-2 by interleukin-1α. J. Biol. Chem. 269:11769.
10. Hla, T., and K. Neilson. 1992. Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. USA 89:7384.
11. Habib, A., C. Creminon, Y. Frobert, J. Grassi, P. Pradelles, and J. Maclouf. 1993. Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2. J. Biol. Chem. 268:23448.
12. Roy, R., P. Polgar, Y. Wang, R. H. Goldstein, L. Taylor, and H. M. Kagan. 1996. Regulation of lysyl oxidase and cyclooxygenase expression in human lung fibroblasts: interactions among TGF-β, IL-1β, and prostaglandin E. J. Cell. Biochem. 62:411.
13. Srivastava, S. K., T. Tetsuka, D. Daphan-Iken, and A. Morrison. 1994. IL-1β stabilizes COX II mRNA in renal mesangial cells: role of 3′-untranslated region. Am. J. Physiol. 267:F504.
14. Yamamoto, K., T. Arakawa, N. Ueda, and S. Yamamoto. 1995. Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270:31315.
15. Geng, Y., F. J. Blanco, M. Cornelisson and M. Lotz. 1995. Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes. J. Immunol. 155:796.
16. Coyne, D. W., M. Nickols, W. Bertrand, and A. R. Morrison. 1992. Regulation of mesangial cell cyclooxygenase synthesis by cytokines and glucocorticoids. Am. J. Physiol. 263 (Pt. 2):F97.
17. Glaser, K. B., and Y. W. Lock. 1995. Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalardial: novel effects independent of inhibition of lipid mediator production. Biochem. Pharmacol. 50:913.
18. Arias-Negrete, S., K. Keller and K. Chadee. 1995. Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages. Biochem. Biophys. Res. Commun. 208:582.
19. Gilbert, R. S., S. T. Reddy, D. A. Kujubu, W. Xie, S. Luner, and H. R. Herschman. 1994. Transforming growth factor beta 1 augments mitogen-induced prostaglandin synthesis and expression of the TIS10/prostaglandin synthase 2 gene both in Swiss 3T3 cells and in murine embryo fibroblasts. J. Cell. Physiol. 159:67.
20. 1 inhibits both endotoxin-induced prostaglandin synthesis and expression of the TIS10/prostaglandin synthase 2 in murine macrophages. J. leukocyte Biol. 55:192.
21. Niiro, H., T. Otsuka, T. Tanabe, S. Hara, S. Kuga, Y. Nemoto, Y. Tanaka, H. Nakashima, S. Kitajima, M. Abe, and Y. Niho. 1995. Inhibition by IL-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: its underlying mechanism in comparison with interleukin-4. Blood 85:3736.
22. Young, H., and K. Hardy. 1995. Role of interferon-γ in immune cell regulation. J. Leukocyte Biol. 58:373.
23. Pace, J. L., S. W. Russell, B. A. Torres, H. M. Johnson, and P. W. Gray. 1983. Recombinant mouse γ-interferon induces the priming step in macrophage activation for tumor cell killing. J. Immunol. 130:2011.
24. Nathan, C. F., H. W. Murray, M. E. Wiebe, and B. Y. Rubin. 1983. Identification of interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and anti-microbial activity. J. Exp. Med. 158:670.
25. Steeg, P., R. N. Moore, H. M. Johnson, and J. J. Oppenheim. 1982. Regulation of murine macrophage la antigen expression by a lymphokine with immune interferon activity. J. Exp. Med. 156:1780.
26. Browning, J. L., and A. Ribolini. 1987. Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes. J. Immunol. 138:2857.
27. 2 release and inducing interleukin 1 production. J. Immunol. 133:764.
28. Endo, T., F. Ogushi, and S. Sone. 1996. LPS-dependent cyclooxygenase-2 induction in human monocytes is down-regulated by IL-13, but not by IFN-γ. J. Immunol. 156:2240.
29. Tada, H., O. Shiho, K. Kuroshima, M. Koyama, and K. Tsukamoto. 1986. An improved colorimetric assay for interleukin 2. J. Immunol. Methods 93:157.
30. Degen, J. L., M. G. Neubauer, S. J. Friezner Degen, C. E. Seyfried, and D. R. Morris. 1983. Regulation of protein synthesis in mitogen-activated bovine lymphocytes: analysis of actin-specific and total mRNA accumulation and utilization. J. Biol. Chem. 258:12153.
31. Ristimakii, A., K. Narko, and T. Hla. 1996. Down-regulation of cytokine-induced cyclooxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation. Biochem. J. 318:325.
32. DeWitt, D., and W. L. Smith. 1995. Yes, but do they still get headaches? Cell 83:345.
33. Crofford, L. J., B. Tan, C. J. McCarthy, and T. Hla. 1997. Involvement of nuclear factor kB in the regulation of cylcooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. Arthritis Rheum. 40:226.
34. 2 synthase (cyclooxygenase) in human monocytes. J. Biol. Chem. 265:16737.
35. 2 synthesis in mouse osteoblasts cultured with interleukin-1. J. Biol. Chem. 272:5952.
36. Riesse, J., T. Hoff, A. Nordhoff, D. L. De Win, K. Resch, and V. Kaever. 1994. Transient expression of prostaglandin endoperoxide synthase-2 during mouse macrophage activation. J. Leukocyte Biol. 55:477.
37. Radzioch, D., and L. Varesio. 1991. C-fos mRNA expression in macrophages is downregulated by interferon-γ at the post-transcriptional level. Mol. Cell Biol. 11:2718.
38. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15:749.
39. Gusella, G. L., T. Musso, M. C. Bosco, I. Espinoza-Delgado, K. Matsushima, and L. Varesio. 1993. IL-2 up-regulates but IFN-γ suppresses IL-8 expression in human monocytes. J. Immunol. 151:2725.
40. Arkins, S., N. Rebeiz, D. L. Brunke-Reese, A. Biragyn, and K. W. Kelley. 1995. Interferon-γ inhibits macrophage insulin-like growth factor-I synthesis at the transcriptional level. Mol. Endocrinol. 9:350.
41. Stewart, R., T. S. Kashour, and P. A. Marsden. 1996. Vascular endothelial platelet endothelial cell adhesion molecule-1 (PECAM-1) expression is decreased by TNF-α and IFN-γ. J. Immunol. 156:1221.
42. Hussaini, I. M., J. LaMarre, J. J. Lysiak, L. R. Karns, S. R. VandenBerg and S. L. Gonias. 1996. Transcriptional regulation of LDL receptor-related protein by IFN-γ and the antagonistic activity of TGF-β1 in the RAW 264.7 macrophage-like cell line. J. Leukocyte Biol 59:733.
43. Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415.
44. Taniguchi, T., H. Harada, and M. Lamphier. 1995. Regulation of the interferon system and cell growth by the IRF transcription factors. J. Cancer Res. Clin. Oncol. 121:516.
45. Xionghu, Y., F. Hou, L. Taylor, and P. Polgar. 1997. Characterization of human cyclooxygenase-2 promoter localization of a TGF-β response element. Biochim. Biophys. Acta 1350:287.
46. Kosaka, T., A. Miyata, H. Ihara, S. Hara, T. Sugimoto, O. Takeda, E. Takahashi, and T. Tanabe. 1994. Characterization of the human gene (PTGS2) encoding prostaglandin endoperoxide synthase 2. Eur. J. Biochem. 221:889.
47. Khan, K. D., K. Shuai, G. Lindwall, S. Maher, J. E. Darnell, Jr., and A. L. M. Bothwell. 1993. Induction of the Ly-6A/E gene by interferon α/β and γ requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds. Proc. Natl. Acad. Sci. USA 90:6806.
48. Decker, T., P. Kovarik, and A. Meinke. 1997. GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression. J. Interferon Cytokine Res. 17:121.
49. Ezernieks, J., B. Schnarr, K. Metz, and A. Duschi. 1996. The human IgE germline promoter is regulated by interleukin-4, interleukin-13, interferon-α and interferon-β via interferon-γ-activated site and its flanking regions. Eur. J. Biochem. 240:667.
50. Lehtonen, A., S. Matikainen, and I. Julkunen. 1997. Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages. J. Immunol. 159:794.