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Volumn 40, Issue 38, 2001, Pages 11525-11532
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Structural and mechanistic insight into the inhibition of aspartic proteases by a slow-tight binding inhibitor from an extremophilic Bacillus sp.: Correlation of the kinetic parameters with the inhibitor induced conformational changes
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Author keywords
[No Author keywords available]
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Indexed keywords
MECHANISTIC INSIGHT;
ENZYME KINETICS;
FLUORESCENCE;
HYDROPHILICITY;
STRUCTURAL ANALYSIS;
TIME AND MOTION STUDY;
ENZYME INHIBITION;
AMINE;
ASPARTIC ACID;
ASPARTIC PROTEINASE;
ASPARTIC PROTEINASE INHIBITOR;
CARBOXYL GROUP;
FUNGAL ENZYME;
GLUTAMIC ACID;
LYSINE;
PEPSIN A;
PEPSTATIN;
PROTEIN ATBI;
TRINITROBENZENESULFONIC ACID;
TRYPTOPHAN;
UNCLASSIFIED DRUG;
ARTICLE;
BACILLUS;
BINDING AFFINITY;
CHEMICAL MODIFICATION;
COMPARATIVE STUDY;
COMPETITIVE INHIBITION;
CONFORMATIONAL TRANSITION;
CONTROLLED STUDY;
ENZYME ACTIVATION;
ENZYME DEGRADATION;
ENZYME INHIBITION;
ENZYME INHIBITOR INTERACTION;
ENZYME STRUCTURE;
FLUORESCENCE;
HYDROPHILICITY;
INHIBITION KINETICS;
ISOMERISM;
NONHUMAN;
PRIORITY JOURNAL;
ASPARTIC ENDOPEPTIDASES;
ASPERGILLUS;
BACILLUS;
BACTERIAL PROTEINS;
KINETICS;
LEAST-SQUARES ANALYSIS;
MODELS, CHEMICAL;
PEPSIN A;
PEPSTATINS;
PROTEASE INHIBITORS;
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EID: 0035949433
PISSN: 00062960
EISSN: None
Source Type: Journal
DOI: 10.1021/bi010594y Document Type: Article |
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Times cited : (17)
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References (44)
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