Pharmacological characterization of in vivo properties of putative mixed 5-HT(1A) agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 2, 1997, Pages 747-759

  Kleven, Mark S ^a   Assié, Marie Bernadette ^a   Koek, Wouter ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [4,4 BIS(4 FLUOROPHENYL)BUTYL] 1 PIPERAZINYL]NICOTINIC ACID; ADATANSERIN; ANXIOLYTIC AGENT; BUSPIRONE; CGS 18102A; KETANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RITANSERIN; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DOPAMINE BLOOD LEVEL; DRUG ACTIVITY; DRUG DISCRIMINATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMPHETAMINES; ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; BENZOPYRANS; DISCRIMINATION (PSYCHOLOGY); KETANSERIN; LYSERGIC ACID DIETHYLAMIDE; MALE; NICOTINIC ACIDS; PIPERAZINES; PIPERIDINES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RITANSERIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030877480     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. ABOU-GHARBIA, M. AND MOYER, J. A.: Wy-50324. Drugs Future 15: 1093-1094, 1990.
2. 2A receptors. Eur. J. Pharmacol. 261: 285-294, 1994.
3. ARNT, J.: Inhibitory effects on the discriminative stimulus properties of D-amphetamine by classical and newer antipsychotics do not correlate With antipsychotic activity. Relation to effects on the reward system? Psychopharmacology 124: 117-125, 1996.
4. 2 receptor affinity and is also influenced by other transmitters. Acta Pharmacol. Toxicol. 55: 363-372, 1984.
5. 1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (S)-WAY10035, but not WAY100635, has partial agonist properties. Eur. J. Pharmacol. 304: 15-21, 1996.
6. 3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics. Eur. J. Pharmacol. 237: 183-189, 1993.
7. BARRETT, J. E. AND VANOVER, K. E.: 5-HT receptors as targets for the development of novel anxiolytic drugs: Models, mechanisms and future directions. Psychopharmacology 112: 1-12, 1993.
8. 2 antagonist WY-50,324 in pigeons. Drug Dev. Res. 24: 179-188, 1991a.
9. 1A activity in the discriminative stimulus effects of imipramine. Pharmacol. Biochem. Behav. 38: 407-410, 1991b.
10. 1A receptors induces lower lip retraction in the rat. Pharmacol. Biochem Behav. 33: 821-827, 1989.
11. 3H-SCH23390, a selective D-1 receptor antagonist ligand, in rat striatum. Life Sci. 35: 1885-1893, 1984.
12. 2A receptor antagonist and 5-HT1A receptor full agonist in rat cerebral cortex. Naunyn Schmiedeberg Arch. Pharmacol. 352: 276-282, 1995.
13. BROCCO, M. J., KOEK, W., DEGRYSE, A.-D. AND COLPAERT, F. C.: Comparative studies on the anti-punishment effects of chlordiazepoxide, buspirone and ritanserin in the pigeon, Geller-Seifter and Vogel conflict procedures. Behav. Pharmacol. 1: 403-418, 1990.
14. 1A agonist and potential anxiolytic agent. Drug Dev. Res. 26: 21-48, 1992.
15. 1A receptor agonists in the mouse. Br. J. Pharmacol. 109: 1046-1052, 1993.
16. 2A receptors are active Under physiological conditions. Psychopharmacology 128: 198-205, 1996.
17. FRAY, P. J., SAHAKIAN, B. J., ROBBINS, T. W., KOOB, G. F. AND IVERSEN, S. D.: An observational method for quantifying the behavioural effects of dopamine agonists: Contrasting effects of d-amphetamine and apomorphine. Psychopharmacology 69: 253-259, 1980.
18. GLEESON, S., AHLERS, S. T., MANSBACH, R. S., FOUST, J. M. AND BARRETT, J. E.: Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes. J. Pharmacol. Exp. Ther. 250: 809-817, 1989.
19. GLENNON, R. A.: Discriminative stimulus properties of the serotonergic agent 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). Life Sci 39: 825-830, 1996.
20. GREUEL, J. M. AND GLASER, T.: The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur. J. Pharmacol. 211: 211-219, 1992.
21. HORNUNG, R., PRESEK, P. AND GLOSSMANN, H.: Alpha adrenoceptors in rat brain: Direct identification with prazosin. Naunyn Schmiedeberg Arch. Pharmacol. 308: 223-230, 1979.
22. HUBERT, J. J.: Bioassay. Dubuque, IA, Kendall/Hunt, 1984.
23. 1c receptors mediate 1-3(chlorophenyl)piperazine-induced hypophagia. Br. J. Pharmacol. 103: 2016-2020, 1991.
24. 2c/2B receptor antagonist. Br. J. Pharmacol. 111: 797-802, 1994.
25. 2A/2C antagonist anxiolytica. I. Antipunishment effects in the pigeon. J. Pharmacol. Exp. Ther. 276: 388-397, 1996.
26. KOEK, W. AND COLPAERT, F. C.: Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: Relationship with phencyclidine-like behavioral effects. J. Pharmacol. Exp. Ther. 252: 349-357, 1990.
27. 1C receptors. Neurosci. Biobehav. Rev. 16: 95-105, 1992.
28. KOEK, W., KLEVEN, M. S. AND COLPAERT, F. C.: Effects of the NMDA antagonist, dizocilpine, in various drug discriminations: Characterization of intermediate levels of drug lever selection. Behav. Pharmacol. 6: 590-600, 1995.
29. 2 receptor antagonist activity. Pharmacol. Biochem. Behav. 47: 301-305, 1994.
30. KULLBACK, S.: Information Theory and Statistics. New York, Dover Publication Inc., 1968.
31. 2 receptor binding sites; binding properties, brain distribution, and functional role. Mol. Pharmacol. 21: 301-314, 1982.
32. 1A receptor antagonist. Pharmacol. Biochem. Behav. 38: 555-559, 1991.
33. LITCHFIELD, J. T., JR. AND WILCOXON, F.: A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96: 99-113, 1949.
34. MIDDLEMISS, D. N. AND TRICKLEBANK, M. D.: Centrally active 5-HT receptor agonists and antagonists. Neurosci. Biobehav. Rev. 16: 75-82, 1992.
35. 1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr-induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity. J. Pharmacol. Exp. Ther. 256: 973-982, 1991a.
36. MILLAN, M. J., CANTON, H. AND LAVIELLE, G.: Targeting multiple serotonin receptors: Mixed 5-HT1A agonists/5-HT1C/2 antagonists as therapeutic agents. Drug News Perspect. 5: 397-406, 1992a.
37. 1c/2 receptors. J. Pharmacol. Exp. Ther. 262: 451-463, 1992b.
38. 1A agonists and antagonists. Pharmacol. Biochem. Behav. 46: 141-143, 1993.
39. 2A receptor affinity. J. Med. Chem. 38: 28-33, 1995.
40. RABIN, R. A. AND WINTER, J. C.: Studies of the biochemical basis for the discriminative properties of 8-hydroxy-2-(di-n-propylamino)tetralin. Eur. J. Pharmacol. 235: 237-243, 1993.
41. RIBLET, L. A., TAYLOR, D. P., EISON, M. S. AND STANTON, H. C.: Pharmacology and neurochemistry of buspirone. J. Clin. Psychiatry 12: 11-16, 1982.
42. 1A agonists. J. Pharmacol. Exp. Ther. 273: 101-112, 1995.
43. SCHREIBER, R., BROCCO, M. AND MILLAN, M. J.: Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the 'atypical' antipsychotics, clozapine and risperidone. Eur. J. Pharmacol. 264: 99-102, 1994.
44. 2 antagonist properties. Prog. Clin. Biol. Res. 361: 469-475, 1990.
45. TALLARIDA, R. J. AND MURRAY, R. B.: Manual of Pharmacological Calculations with Computer Programs. New York, Springer Verlag, 1987.
46. 1-receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur. J. Pharmacol. 106: 271-282, 1984.
47. 1A receptors. J. Clin. Psychopharmacol. 10: 6S-12S, 1990
48. YOCCA, F. D., WRIGHT, R. N., MARGRAF, R. R. AND EISON, A. S.: 8-OH-DPAT and buspirone analogs inhibit the ketanserin-sensitive quipazine-induced head shake response in rats. Pharmacol. Biochem. Behav. 35: 251-254, 1990.