Genetic association of two chromosome 14 genes (presenilin 1 and α1- antichymotrypsin) with Alzheimer's disease

Annals of Neurology

Volumn 44, Issue 3, 1998, Pages 387-390

  Wang, Xiaoyan ^a   DeKosky, Steven T ^b   Wisniewski, Stephen ^c   Aston, Christopher E ^a   Kamboh, M Ilyas ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; PRESENILIN 1;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 14; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ANALYSIS; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT;

AGED; AGED, 80 AND OVER; ALLELES; ALPHA 1-ANTICHYMOTRYPSIN; ALZHEIMER DISEASE; CHROMOSOMES, HUMAN, PAIR 14; DISEASE SUSCEPTIBILITY; FEMALE; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; MEMBRANE PROTEINS; PRESENILIN-1;

EID: 0031693552     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410440316     Document Type: Article

References (20)

1. Hardy J. Molecular genetics of Alzheimer's disease. Acta Neurol Scand 1996;165(Suppl):13-17
2. Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. JAMA 1997;278: 1349-1356
3. 1-antichymotrypsin polymorphism. Nat Genet 1995;10:486-488
4. Thome J, Baumer A, Kornhuber J, et al. Alpha-1-antichymotrypsin bi-allele polymorphism, apolipoprotein-E tri-allele polymorphism and genetic risk of Alzheimer's syndrome. J Neural Transm Park Dis Dement Sect 1995;10:207-212
5. 1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E ε4 allele carriers. Ann Neurol 1997;42:115-117
6. 1-Antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish population. Neurosci Lett 1998;240:107-109
7. Muramatsu T, Matsushita S, Arai H, et al. Alpha 1-antichymotrypsin gene polymorphism and risk for Alzheimer's disease. J Neural Transm Park Dis Dement Sect 1996;103:1205-1210
8. Talbot C, Houlden H, Craddock N, et al. Polymorphism in AACT gene may lower age of onset of Alzheimer's disease. Neuroreport 1996;7:534-536
9. Haines JL, Pritchard ML, Saunders AM, et al. No genetic effect of alphal-antichymotrypsin in Alzheimer disease. Genomics 1996;33:53-56
10. Murphy GM Jr, Sullivan EV, Gallagher-Thompson D, et al. No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease. Neurology 1997;48:1313-1316
11. Fallin D, Reading S, Schinka J, et al. No interaction between the APOE and the alpha-1-antichymotrypsin genes on risk for Alzheimer's disease. Am J Med Genet 1997;74:192-194
12. 1-antichymotrypsin polymorphism in Alzheimer's disease. Ann Neurol 1996;40:678-680
13. Wragg M, Hutton M, Talbot C. Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease: Alzheimer's Disease Collaborative Group. Lancet 1996;347:509-512
14. Nishiwaki Y, Kamino K, Yoshiiwa A, et al. T/G polymorphism at intron 9 of presenilin 1 gene is associated with, but not responsible for sporadic late-onset Alzheimer's disease in Japanese population. Neurosci Lett 1997;227:123-126
15. Higuchi S, Muramatsu T, Matsushita S, et al. Presenilin-1 polymorphism and Alzheimer's disease. Lancet 1996;347:1186
16. Scott WK, Yamaoka LH, Locke PA, et al. No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease. Genet Epidemiol 1997;14:307-315
17. Tysoe C, Whittaker J, Cairns NJ, et al. Presenilin-1 intron 8 polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease. Neurosci Lett 1997;222:68-69
18. Kamboh MI, Aston CE, Hamman RF. The relationship of APOE polymorphism and cholesterol levels in normoglycemic and diabetic subjects in a biethnic population from the San Luis Valley, Colorado. Atherosclerosis 1995;112:145-159
19. Higuchi M, Arai H, Nakagawa T, et al. Regional cerebral glucose utilization is modulated by the dosage of apolipoprotein E type 4 allele and alphal-antichymotrypsin type A allele in Alzheimer's disease. Neuroreport 1997;8:2639-2643
20. Pericak-Vance MA, Bass MP, Yamaoka LH, et al. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA 1997;278: 1237-1241