Modulation of airway remodeling-associated mediators by the antifibrotic compound, pirfenidone, and the matrix metalloproteinase inhibitor, batimastat, during acute lung injury in mice

European Journal of Pharmacology

Volumn 426, Issue 1-2, 2001, Pages 113-121

  Corbel, Marianne ^a   Lanchou, Jérôme ^a,b   Germain, Noëlla ^a   Malledant, Yannick ^a,b   Boichot, Elisabeth ^a   Lagente, Vincent ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

Batimastat; Bronchoalveolar lavage; Lipopolysaccharide; Matrix metalloproteinase (MMP); Pirfenidone; TIMP (tissue inhibitor of matrix metalloproteinase)

Indexed keywords

ANTIFIBROTIC AGENT; BACTERIUM LIPOPOLYSACCHARIDE; BATIMASTAT; GELATINASE; GELATINASE B; MATRIX METALLOPROTEINASE INHIBITOR; PIRFENIDONE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

AEROSOL; AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; IMMUNOMODULATION; LUNG INJURY; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LUNG; LUNG DISEASES; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED BALB C; PHENYLALANINE; PYRIDONES; THIOPHENES; TISSUE INHIBITOR OF METALLOPROTEINASES; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035943338     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01209-2     Document Type: Article

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