Effects of sex and age on atherosclerosis and autoimmunity in apoE-deficient mice

Atherosclerosis

Volumn 145, Issue 2, 1999, Pages 301-308

  Caligiuri, Giuseppina ^a   Nicoletti, Antonino ^a,b   Zhou, Xinghua ^a   Törnberg, Ingrid ^a   Hansson, Göran K ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b HÔPITAL BROUSSAIS   (France)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Ageing; Atherosclerosis; Autoimmunity; Estrogens; Modified lipoproteins; Oxidation; T cells

Indexed keywords

ESTRADIOL; ESTROGEN; OXIDIZED LOW DENSITY LIPOPROTEIN;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; AUTOIMMUNITY; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; HYPERLIPOPROTEINEMIA TYPE 3; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

AGE FACTORS; ANIMALS; AORTA, THORACIC; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; AUTOANTIGENS; AUTOIMMUNITY; CELL DIVISION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ESTRADIOL; FEMALE; IMMUNITY, CELLULAR; LIPOPROTEINS, LDL; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SEX FACTORS; SPLEEN; T-LYMPHOCYTES;

EID: 0032774697     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00081-7     Document Type: Article

References (26)

1. Plump AS, Smith JD, Hayek T, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 1992;71:343-53.
2. Zhou X, Stemme S, Hansson GK. Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice. Am J Pathol 1996;149:359-66.
3. Palinski W, Ord VA, Plump AS, Breslow JL, Steinberg D, Witztum JL. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler Thromb 1994;14:605-16.
4. Hansson GK. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol 1998;9:73-5.
5. Kannel WB. Prevalence, incidence, and mortality of coronary heart disease. In: Fuster V, Ross R, Topol EJ, editors. Atherosclerosis and coronary artery disease. Philadelphia: Lippincott-Raven, 1996:13-21 Vol. 1.
6. Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med 1991;20:47-63.
7. Holmdahl R, Carlsten H, Jansson L, Larsson P. Oestrogen is a potent immunomodulator of murine experimental rheumatoid disease. Br J Rheumatol 1989;28:54-8.
8. Carlsten H, Nilsson N, Jonsson R, Backman K, Holmdahl R, Tarkowski A. Estrogen accelerates immune complex glomerulonephritis but ameliorates T cell-mediated vasculitis and sialadenitis in autoimmune MRL lpr/lpr mice. Cell Immunol 1992;144:190-202.
9. Carlsten H, Tarkowski A, Holmdahl R, Nilsson LA. Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice. Clin Exp Immunol 1990;80:467-73.
10. Carlsten H, Nilsson N, Jonsson R, Tarkowski A. Differential effects of oestrogen in murine lupus: acceleration of glomerulonephritis and amelioration of T cell-mediated lesions. J Autoimmun 1991;4:845-56.
11. Carlsten H, Tarkowski A. Histocompatibility complex gene products and exposure to oestrogen: two independent disease accelerating factors in murine lupus. Scand J Immunol 1993;38:341-7.
12. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 1987;68:231-40.
13. Bourassa PA, Milos PM, Gaynor BJ, Breslow JL, Aiello RJ. Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice. Proc Natl Acad Sci USA 1996;93:10022-7.
14. Elhage R, Arnal JF, Pieraggi MT, et al. 17 beta-estradiol prevents fatty streak formation in apolipoprotein E- deficient mice. Arterioscler Thromb Vasc Biol 1997;17:2679-84.
15. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb Vasc Biol 1994;14:133-40.
16. Palinski W, Tangirala RK, Miller E, Young SG, Witztum JL. Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis. Arterioscler Thromb Vasc Biol 1995;15:1569-76.
17. Stemme S, Faber B, Holm J, Wiklund O, Witztum JL, Hansson GK. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc Natl Acad Sci USA 1995;92:3893-7.
18. Steinbrecher UP. Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products. J Biol Chem 1987;262:3603-8.
19. Paigen B, Holmes PA, Mitchell D, Albee D. Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H. Atherosclerosis 1987;64:215-21.
20. Zuckerman SH, Bryan-Poole N, Evans GF, Short L, Glasebrook AL. In vivo modulation of murine serum tumour necrosis factor and interleukin-6 levels during endotoxemia by oestrogen agonists and antagonists. Immunology 1995;86:18-24.
21. Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Nat Med 1996;2:1132-6.
22. Josefsson E, Tarkowski A, Carlsten H. Anti-inflammatory properties of estrogen. I. In vivo suppression of leukocyte production in bone marrow and redistribution of peripheral blood neutrophils. Cell Immunol 1992;142:67-78.
23. Nilsson N, Carlsten H. Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation. Cell Immunol 1994;158:131-9.
24. Huber SA, Pfaeffle B. Differential Th1 and Th2 cell responses in male and female BALB/c mice infected with coxsackievirus group B type 3. J Virol 1994;68:5126-32.
25. Fox HS, Bond BL, Parslow TG. Estrogen regulates the IFN-gamma promoter. J Immunol 1991;146:4362-7.
26. Gilmore W, Weiner LP, Correale J. Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects. J Immunol 1997;158:446-51.