Quinazolin-4-one α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists: Structure-activity relationship of the C-2 side chain tether

Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2001, Pages 1710-1717

  Chenard, B L ^a   Welch, W M ^a   Blake, J F ^a   Butler, T W ^a   Reinhold, A ^a   Ewing, F E ^a   Menniti, F S ^a   Pagnozzi, M J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR ANTAGONIST; QUINAZOLIN 4 ONE ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; MOLECULAR MODEL; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIUM; CELLS, CULTURED; CEREBELLUM; EXCITATORY AMINO ACID ANTAGONISTS; MODELS, MOLECULAR; QUINAZOLINES; RATS; RECEPTORS, AMPA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035942523     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000522p     Document Type: Article

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