Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 14, 2001, Pages 1817-1821

  Beshore, Douglas C ^a   Bell, Ian M ^a   Dinsmore, Christopher J ^a   Homnick, Carl F ^a   Culberson, J Christopher ^a   Robinson, Ronald G ^a   Fernandes, Christine ^a   Walsh, Eileen S ^a   Abrams, Marc T ^a   Bhimnathwala, Hema G ^a   Davide, Joseph P ^a   Ellis Hutchings, Michelle S ^a   Huber, Hans A ^a   Koblan, Kenneth S ^a   Buser, Carolyn A ^a   Kohl, Nancy E ^a   Lobell, Robert B ^a   Chen, I Wu ^a   McLoughlin, Debra A ^a   Olah, Timothy V ^a   Graham, Samuel L ^a   Hartman, George D ^a   Williams, Theresa M ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; GERANYLGERANYL PROTEIN TRANSFERASE 1; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DOG; DRUG ACTIVITY; DRUG CONFORMATION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; AMINO ACIDS; ANIMALS; CELLS, CULTURED; DOGS; ENZYME INHIBITORS; HALF-LIFE; INHIBITORY CONCENTRATION 50; METABOLIC CLEARANCE RATE; MOLECULAR CONFORMATION; PROTEIN BINDING; RATS;

EID: 0035939296     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00340-7     Document Type: Article

References (20)