Stereoselective inhibition of human butyrylcholinesterase by phosphonothiolate analogs of (+)- and (-)-cocaine

Biochemical Pharmacology

Volumn 54, Issue 11, 1997, Pages 1261-1266

  Berkman, Clifford E ^a   Underiner, Gail E ^a   Cashman, John R ^a  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

(+) and ( ) phosphonothiolate inhibitors; Cocaine detoxication; Human butyrylcholinesterase mechanism; Stereoselective enzyme inhibition; Transition state mechanism based inhibitors

Indexed keywords

CHOLINESTERASE; COCAINE; ECGONINE METHYL ESTER;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG HYDROLYSIS; ENANTIOMER; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL;

BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COCAINE; HUMANS; PHOSPHONIC ACIDS; STEREOISOMERISM;

EID: 0030668820     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00403-6     Document Type: Article

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