Phosphorylation Site Mutations in Heterochromatin Protein 1 (HP1) Reduce or Eliminate Silencing Activity

Journal of Biological Chemistry

Volumn 276, Issue 12, 2001, Pages 9512-9518

  Zhao, Tao ^b   Heyduk, Tomasz ^b   Eissenberg, Joel C ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DESORPTION; GENES; IONIZATION; LASER APPLICATIONS; MASS SPECTROMETRY; MUTAGENESIS;

PHOSPHORYLATION; TRANSGENIC FLIES;

PROTEINS;

ALANINE; CASEIN KINASE II; GLUTAMIC ACID; HETEROCHROMATIN PROTEIN 1; INSECT PROTEIN; MUTANT PROTEIN; PHOSPHOPEPTIDE; PHOSPHOTRANSFERASE; PROTEIN KINASE; PROTEIN KINASE PIM 1; PROTEIN TYROSINE KINASE; SERINE; UNCLASSIFIED DRUG; VIRUS VECTOR; DNA; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BACULOVIRUS; CONSENSUS SEQUENCE; CORRELATION ANALYSIS; DOSE RESPONSE; DROSOPHILA; EUCHROMATIN; GENE EXPRESSION; GENE LOCATION; GENE MUTATION; GENE SILENCING; HETEROCHROMATIN; IN VIVO STUDY; INSECT CELL CULTURE; LEPIDOPTERA; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DEPHOSPHORYLATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; REGULATORY MECHANISM; TRANSGENIC ANIMAL; VIRUS RECOMBINANT; ANIMAL; ARMYWORM; CHEMISTRY; CIRCULAR DICHROISM; GENETICS; MASS SPECTROMETRY; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING;

ANIMALIA; ARACHNIDA; BACTERIA (MICROORGANISMS); HEXAPODA; INSECTA; LEPIDOPTERA; UNIDENTIFIED BACULOVIRUS;

ANIMALS; CIRCULAR DICHROISM; DNA; DROSOPHILA; GENE SILENCING; HETEROCHROMATIN; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPODOPTERA;

EID: 0035937710     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010098200     Document Type: Article

References (49)

1. James, T. C., and Elgin, S. C. R. (1986) Mol. Cell. Biol. 6, 3862-3872
2. James, T. C., Eissenberg, J. C., Craig, C., Dietrich, V., Hobson, A., and Elgin, S. C. R. (1989) Eur. J. Cell Biol. 50, 170-180
3. Wustmann, G., Szidonya, J., Taubert, H., and Reuter, G. (1989) Mol. Gen. Genet. 217, 520-527
4. Eissenberg, J. C., James, T. C., Foster-Hartnett, D. M., Hartnett, T., Ngan, V., and Elgin, S. C. R. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 9923-9927
5. Eissenberg, J. C., Morris, G. D., Reuter, G., and Hartnett, T. (1992) Genetics 131, 345-352
6. Lu, B. Y., Emtage, P. C. R., Duyf, B. J., Hilliker, A. J., and Eissenberg, J. C. (2000) Genetics 155, 699-708
7. Eissenberg, J. C., and Hartnett, T. (1993) Mol. Gen. Genet. 240, 333-338
8. Fanti, L., Giovinazzo, G., Berloco, M., and Pimpinelli, S. (1998) Mol. Cell 2, 527-538
9. Eissenberg, J. C., and Elgin, S. C. R. (2000) Curr. Opin. Genet. & Dev. 10, 204-210
10. Lorentz, A., Ostermann, K., Fleck, O., and Schmidt, H. (1994) Gene (Amst.) 143, 139-143
11. Festenstein, R., Sharghi-Namini, S., Fox, M., Roderick, K., Tolaini, M., Norton, T., Saveliev, A., Kioussis, D., and Singh, P. (1999) Nat. Genet. 23, 457-461
12. Ball, L. J., Murzina, N. V., Broadhurst, R. W., Raine, A. R. C., Archer, S. J., Stott, F. J., Murzina, A. G., Singh, P. B., Domaille, P. F., and Laue, E. D. (1997) EMBO J. 16, 2473-2481
13. Brasher, S. V., Smith, B. O., Fogh, R. H., Nietispach, D., Thiru, A., Nielsen, P. R., Broadhurst, R. W., Ball, L. J., Murzina, N. V., and Laue, E. D. (2000) EMBO J. 19, 1587-1597
14. Edmondson, S. P., Qiu, L., and Shriver, J. W. (1995) Biochemistry 34, 13289-13304
15. Robinson, H., Gao, Y.-G., McCrary, B. S., Edmondson, S. P., Shriver, F. W., and Wang, A. H.-J. (1998) Nature 392, 202-205
16. Smothers, J. F., and Henikoff, S. (2000) Curr. Biol. 10, 27-30
17. Zhao, T., Heyduk, T., Allis, C. D., and Eissenberg, J. C. (2000) J. Biol. Chem. 275, 28332-28338
18. Le Douarin, B., Nielsen, A. L., Garnier, J. M., Ichinose, H., Jeanmougin, F., Losson, R., and Chambon, P. (1996) EMBO J. 15, 6701-6715
19. Cléard, F., Delattre, M., and Spierer, P. (1997) EMBO J. 16, 5280-5288
20. Ryan, R. F., Schultz, D. C., Ayyanathan, K., Singh, P. B., Friedman, J. R., Fredericks, W. J., and Rauscher, F. J., III. (1999) Mol. Cell. Biol. 19, 4366-4378
21. Nielsen, A. L., Ortiz, J. A., You, J., Oulad-Abdelghani, M., Khechumian, R., Gansmuller, A., Chambon, P., and Losson, R. (1999) EMBO J. 18, 6385-6395
22. Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P. B., Reuter, G., and Jenuwein, T. (1999) EMBO J. 18, 1923-1938
23. Ye, Q., and Worman, H. J. (1996) J. Biol. Chem. 271, 14653-14656
24. Ye, Q., Callebaut, I., Pezhman, A., Courvalin, J. C., and Worman, H. J. (1997) J. Biol. Chem. 272, 14983-14989
25. Pak, D. T. S., Pflumm, M., Chesnodov, I., Huang, D. W., Kellum, R., Marr, J., Romanowski, P., and Botchan, M. R. (1997) Cell 91, 311-323
26. Murzina, N., Verreault, A., Laue, E., and Stillman, B. (1999) Mol. Cell 4, 529-540
27. Eissenberg, J. C., Ge, Y.-W., and Hartnett, T. (1994) J. Biol. Chem. 269, 21315-21321
28. Huang, H., Smothers, J. F., Wiley, E. A., and Allis, C. D. (1999) Mol. Cell. Biol. 19, 3624-3634
29. Minc, E., Allory, Y., Courvalin, J.-C., Worman, H. J., and Buendia, B. (1999) Chromosoma 108, 220-234
30. Koike, N., Maita, H., Taira, T., Ariga, H., and Iguchi-Ariga, S. M. M. (2000) FEBS Lett. 467, 17-21
31. Huang, D. W., Fanti, L., Pak, D. T., Botchan, M. R., Pimpinelli, S., and Kellum, R. (1998) J. Cell Biol. 142, 307-318
32. Zhao, T., and Eissenberg, J. C. (1999) J. Biol. Chem. 274, 15095-15100
33. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual, p. 505, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
34. Platero, J. S., Hartnett, T., and Eissenberg, J. C. (1995) EMBO J. 14, 3977-3986
35. Ephrussi, B., and Herold, J. L. (1944) Genetics 29, 148-175
36. Liao, P.-C., Leykam, J., Andrews, P. D., Gage, D. A., and Allison, J. (1994) Anal. Biochem. 219, 9-20
37. Herskowitz, I. (1987) Nature 329, 219-222
38. Leverson, J. D., Doskinen, P. F., Orricol, F. C., Raino, E.-M., Jalkanen, K. F., Dash, A. B., Eisenman, R. N., and Ness, S. A. (1998) Mol. Cell 2, 417-425
39. Mochizuki, T., Kitanaka, C., Noguchi, K., Muramatsu, T., Asai, A., and Kuchino, Y. (1999) J. Biol. Chem. 274, 18659-18666
40. Salzberg, A., Prokopenko, S. N., He, Y., Tsai, P., Pal, M., Maroy, P., Glover, D. M., Deak, P., and Bellen, H. J. (1997) Genetics 147, 1723-1741
41. Beckstead, R., Prokopenko, S., Losson, R., Chambon, P., and Bellen, H. (1999) Ann. Dros. Res. Conf 40, a149
42. Sugimoto, K., Yamada, T., Muro, Y., and Himeno, M. (1996) J. Biochem. (Tokyo) 120, 153-159
43. Hunter, T., and Karin, M. (1992) Cell 70, 375-387
44. Meek, D. W., and Street, A. J. (1992) Biochem. J. 287, 1-15
45. Caelles, C., Hennemann, H., and Karin, M. (1995) Mol. Cell. Biol. 15, 6694-6701
46. Armstrong, S. A., Barry, D. A., Leggett, R. W., and Mueller, C. R. (1997) J. Biol. Chem. 272, 13489-13495
47. Banks, G. C., Li, Y., and Reeves, R. (2000) Biochemistry 39, 8333-8346
48. Huang, M., Zhou, Z., and Elledge, S. J. (1998b) Cell 94, 595-605
49. Cowley, D. O., and Graves, B. J. (2000) Genes Dev. 14, 366-376