Cardiovascular pharmacology of SKP-450, a new potassium channel activator, and its major metabolites SKP-818 and SKP-310

Pharmacology

Volumn 56, Issue 3, 1998, Pages 111-124

  Shin, Hwa Sup ^a   Seo, Ho Won ^a   Yoo, Sung Eun ^a   Lee, Byung Ho ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Antihypertension; Hemodynamics; KR 30450; Potassium channel activator; SKP 450

Indexed keywords

2 (1,3 DIOXOLAN 2 YL) 2 METHYL 6 NITRO 4 (2 OXO 1 PYRROLIDINYL) 2H 1 BENZOPYRAN; ANTIHYPERTENSIVE AGENT; GLIBENCLAMIDE; LEMAKALIM; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; PROPRANOLOL; SKP 310; SKP 818; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR EFFECT; CORONARY ARTERY BLOOD FLOW; DOG; DRUG ANTAGONISM; DRUG POTENCY; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; TACHYCARDIA; THORACIC AORTA;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA, THORACIC; BENZOPYRANS; CORONARY CIRCULATION; CROMAKALIM; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMODYNAMIC PROCESSES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NOREPINEPHRINE; POTASSIUM CHANNELS; PYRROLES; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATION; VASODILATOR AGENTS;

EID: 0031931948     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028188     Document Type: Article

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