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Volumn 48, Issue 10, 1998, Pages 969-978
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Antihypertensive effects of the novel potassium channel activator SKP- 450 and its major metabolites in rats
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Author keywords
( ) (2R) 2' (1',3' Dioxolan 2 yl) 2 methyl 4 (2' oxopyrrolidin 1 yl) 6 nitro 2H 1 benzopyran; Antihypertensive agent; CAS 172489 10 0; KR 30450; Potassium channel activator; SKP 310; SKP 450, antihypertensive effects, metabolites; SKP 818
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Indexed keywords
15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID;
2 (1,3 DIOXOLAN 2 YL) 2 METHYL 6 NITRO 4 (2 OXO 1 PYRROLIDINYL) 2H 1 BENZOPYRAN;
2'' (1'',3'' DIOXOLAN 2 YL) 2 METHYL 4 (2' OXOPYRROLIDIN 1 YL) 6 NITRO 2H 1 BENZOPYRAN;
2'' CARBOXY 2 METHYL 4 (2' OXOPYRROLIDI 1 YL) 6 NITRO 2H 1 BENZOPYRAN;
2'' HYDROXYMETHYL 2 METHYL 4 (2' OXOPYRROLIDIN 1 YL) 6 NITRO 2H 1 BENZOPYRAN;
ACETYLCHOLINE;
ANGIOTENSIN;
BENZOPYRAN DERIVATIVE;
CARBOXYMETHYLCELLULOSE;
DEOXYCORTICOSTERONE ACETATE;
DIMETHYL SULFOXIDE;
DRUG METABOLITE;
DRUG VEHICLE;
HISTAMINE;
LEMAKALIM;
N(G) NITROARGININE METHYL ESTER;
NITROPRUSSIDE SODIUM;
NORADRENALIN;
POTASSIUM CHANNEL;
POTASSIUM CHANNEL STIMULATING AGENT;
POTASSIUM CHLORIDE;
SKP 310;
SKP 818;
SODIUM NITRITE;
UNCLASSIFIED DRUG;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANIMAL TISSUE;
ANTIHYPERTENSIVE ACTIVITY;
ARTICLE;
BLOOD VESSEL REACTIVITY;
CHANNEL GATING;
CONTROLLED STUDY;
DRUG POTENCY;
HEART RATE;
INTRAVENOUS DRUG ADMINISTRATION;
ISOLATED ARTERY;
MALE;
MEAN ARTERIAL PRESSURE;
NONHUMAN;
ORAL DRUG ADMINISTRATION;
RAT;
RENOVASCULAR HYPERTENSION;
SPONTANEOUSLY HYPERTENSIVE RAT;
SUBCUTANEOUS DRUG ADMINISTRATION;
VASODILATATION;
ANIMALS;
ANTIHYPERTENSIVE AGENTS;
BENZOPYRANS;
BLOOD PRESSURE;
CROMAKALIM;
DESOXYCORTICOSTERONE;
HEART RATE;
HYPERTENSION;
HYPERTENSION, RENAL;
MALE;
POTASSIUM CHANNELS;
PYRROLES;
PYRROLIDINONES;
RATS;
RATS, INBRED SHR;
VASODILATOR AGENTS;
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EID: 0038606228
PISSN: 00044172
EISSN: None
Source Type: Journal
DOI: None Document Type: Article |
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Times cited : (8)
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References (29)
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