Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1, 2-a]indeno-[1, 2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 2, 2001, Pages 127-132

  Jimonet, Patrick ^a   Bohme, Georg Andrees ^a   Bouquerel, Jean ^a   Boireau, Alain ^a   Damour, Dominique ^a   Debono, Marc Williams ^a   Genevois Borella, Arielle ^a   Hardy, Jean Claude ^a   Hubert, Philippe ^a   Manfré, Franco ^a,b   Nemecek, Patrick ^a   Pratt, Jeremy ^a   Randle, John C R ^a,c   Ribeill, Yves ^a,d   Stutzmann, Jean Marie ^a   Vuilhorgne, Marc ^a   Mignani, Serge ^a  

^a SANOFI   (France)

^b Rhodia Europe   (France)

^c VERTEX PHARMACEUTICALS   (United States)

^d Aventis Crop Science   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 (1H TETRAZOL 5 YLMETHYL) 4 OXO 5,10 DIHYDROIMIDAZO[1,2 A]INDENO[1,2 E]PYRAZIN 2 YLPHOSPHONIC ACID; 9 CARBOXYMETHYL 4 OXOIMIDAZO[1,2 A]INDENO[1,2 E]PYRAZIN 2 CARBOXYLIC ACID DERIVATIVE; AMPA RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CONVULSION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTICONVULSANTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MALE; MICE; OOCYTES; PYRAZINAMIDE; PYRAZINES; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035931586     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00592-8     Document Type: Article

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