Experimental studies on the evolution of antimony-resistant phenotype during the in vitro life cycle of Leishmania infantum: Implications for the spread of chemoresistance in endemic areas

Acta Tropica

Volumn 80, Issue 3, 2001, Pages 195-205

  Sereno, D ^a   Guilvard, E ^a   Maquaire, S ^a   Cavaleyra, M ^a   Holzmuller, P ^a   Ouaissi, A ^a   Lemesre, J L ^a  

^a INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

Author keywords

Antimonyl resistant amastigotes; Leishmania infantum; Parasite's life cycle; Phenotype transmission

Indexed keywords

ANTIMONY TARTRATE; MEGLUMINE ANTIMONATE; STIBOGLUCONATE SODIUM;

ANTIMONY; DRUG RESISTANCE; LEISHMANIASIS; PHENOTYPE;

AMASTIGOTE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SENSITIVITY; EVOLUTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEISHMANIA INFANTUM; LIFE CYCLE; NONHUMAN; PARASITE IDENTIFICATION; PARASITE TRANSMISSION; PHENOTYPE; PROMASTIGOTE; TOXICITY;

ANIMALS; ANTIMONY; ANTIPROTOZOAL AGENTS; CELL LINE; DRUG RESISTANCE; ENDEMIC DISEASES; HUMANS; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LIFE CYCLE STAGES; PARASITIC SENSITIVITY TESTS; PHENOTYPE;

LEISHMANIA INFANTUM;

EID: 0035930386     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0001-706X(01)00154-1     Document Type: Article

References (38)

1. Cultivation and characterization of Leishmania mexicana amastigote-like forms
2. Complete developmental cycle of Leishmania mexicana in axenic culture
3. Axenic culture of Leishmania amastigotes
4. A comparative study of Leishmania mexicana amastigotes and promastigotes. Enzyme activities and subcellular locations
5. Three-dimensional structure of the Leishmania amastigote as revealed by computer-aided reconstruction from serial sections
6. Double blood meals by Phlebotomus argentipes and P. papatasi in two villages of Maharashtra
7. The biochemistry of P-glycoprotein mediated multidrug resistance
8. In vitro and in vivo resistance of Leishmania infantum to meglumine antimoniate: A study of 37 strains collected from patients with visceral leishmaniasis
9. Methotrexate-resistant chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate
10. An in vitro model for screening antileishmanial drugs: The human leukemia monocyte cell line, THP-1
11. The morphology and fine structure of the midgut and peritrophic membrane of the adult female, Phlebotomus longipes Parrot and Martin (Diptera: Psychodidae)
12. Drug resistance in leishmaniasis: It's implication in systemic chemotherapy of cutaneous and mucocutaneous disease
13. Histologic detection of multiple blood meals in Phlebotomus duboscqi (Diptera: Psychodidae)
14. Leishmania mexicana, purine metabolizing enzymes of amastigotes and promastigotes
15. Leishmania spp: Nitric oxide-mediated metabolic inhibition of promastigote and axenically-grown amastigote forms
16. Evidence that the high incidence of treatment failures in Kala-Azar is due to the emmergence of antimony-resistant strains of Leishmania donovani
17. Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania
18. Use of the polymerase chain reaction to assess the success of visceral leishmaniasis treatment
19. The amplified H circle of methotrexate-resistant Leishmania tarentolae contains a novel P-glycoprotein gene
20. Mechanisms of drug resistance in Leishmania
21. Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug-resistant Leishmania
22. Amplification of ABC transporter gene pgpA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption
23. ABC transporters in Leishmania and their role in drug resistance
24. Visceral Leishmaniasis in HIV infection and AIDS: Clinical feature and response to therapy
25. Présence simultannée chez le chien de deux zymodèmes du complexe Leishmania infantum
26. Biochemical and molecular characterization of Leishmania pifanoi amastigotes in continuous axenic culture
27. Axenically cultured amastigote forms as an in vitro model for investigation of antileishmanial agents
28. In vitro life cycle of pentamidine-resistant amastigotes: Stability of the chemoresistant phenotypes is dependent on the level of resistance induced
29. Use of an enzymatic in vitro micromethod to quantify amastigote stage of axenically grown amastigote forms of Leishmania amazonensis
30. Phenotypic characterization of Leishmania mexicana pentamidine-resistant promastigotes: Modulation of the resistance during developmental life cycle
31. Axenically-grown amastigotes of Leishmania infantum used as an in vitro model to investigate the pentavalent antimony mode of action
32. Efficacy of second line drugs on antimonyl-resistant amastigotes of Leishmania infantum
33. A clonal theory of parasitic protozoa: The population structure of Entamoebia, Giardia, Leishmnania, Nalgeria, Plasmodium, Trichomonas and Trypanosoma, and its medical and taxonomical consequences
34. Population genetics of parasitic protozoa and other microorganisms
35. Beyond strain typing and molecular epidemiologiy: Integrated genetic epidemiology of infectious diseases
36. Induction of maturation in cultured human monocytic leukemia cells by phorbol diester
37. Current status and evolution of antimalarial drug resistance