Subtle differences in the mitogenic effects of recombinant human bone morphogenetic proteins -2 to -7 on DNA synthesis on primary bone-forming cells and identification of BMP-2/4 receptor

Calcified Tissue International

Volumn 58, Issue 4, 1996, Pages 249-255

  Mayer, H ^a   Scutt, A M ^b   Ankenbauer, T ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

superfamily; Bone cells; Cell proliferation; Transforming growth factor

Indexed keywords

BONE MORPHOGENETIC PROTEIN; TRANSFORMING GROWTH FACTOR;

ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL PROLIFERATION; CHICK EMBRYO; CROSS LINKING; DNA SYNTHESIS; EPIPHYSIS; HUMAN; HUMAN CELL; OSTEOBLAST; PERIOSTEUM; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN RECEPTORS; BONE MORPHOGENETIC PROTEINS; CARTILAGE; CELL DIVISION; CELLS, CULTURED; CHICK EMBRYO; CHICKENS; CHO CELLS; CRICETINAE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIPHYSES; GROWTH SUBSTANCES; HUMANS; RECEPTORS, CELL SURFACE; RECEPTORS, GROWTH FACTOR; RECOMBINANT PROTEINS; STERNUM; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029932235     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900043     Document Type: Article

References (35)

1. Urist MR (1965) Bone formation by autoinduction. Science 150:893-899
2. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Kewick, RM, Wang EA (1988) Novel regulators of bone formation: molecular clones and activities. Science 242:1528-1534
3. Chen TL, Bates RL, Dudley A, Hammonds RG, Amento EP (1991) Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: comparison with TGF-β1. J Bone Miner Res 6:1387-1393
4. Sampath TK, Maliakal JC, Hauschka PV, Jones WK, Sasak H, Tucker RF, White KH, Coughlin JE, Tucker MM, Pang RHL, Corbett C, Özkaynak E, Oppermann H, Rueger DC (1992) Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 267:20352-20362
5. Vukicevic S, Luyten FP, Reddi AH (1989) Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin. Proc Natl Acad Sci (USA) 86:8793-8797
6. Knutsen R, Mohan S, Wergedal JI, Sampath K, Baylink DJ (1991) Osteogenic protein-1 (OP-I) stimulates proliferation and differentiation of human bone cells (HBC) in vitro. J Bone Miner Res 6:141
7. Yamaguchi A, Katagiri T, Ikeda T, Wozney JM, Rosen V, Wang EA, Kahn AJ, Suda T, Yoshiki S (1991) Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 113:681-687
8. Wang EA, Rosen V, Cordes P, Hewick RM, Kriz MJ, Luxenberg DP, Sibley BS, Wozney JM (1990) Recombinant human bone morphogenetic protein induces bone formation Proc Natl Acad Sci (USA) 87:2220-2224
9. Wang EA, Rosen V, Cordes P, Hewick RM, Kriz MJ, Luxenberg DP, Sibley BS, Wozney JM (1988) Purification and characterization of other distinct bone-inducing factors. Proc Natl Acad Sci (USA) 85:9484-9488
10. Wozney JM (1992) The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev 32:160-167
11. 2 on DNA synthesis by periosteal cells from embryonic chick calvaria Calcif Tissue Int 55:208-215
12. Cohen FE, Strewler GJ, Bradley MS, Carlquist M, Nilsson M, Ericsson M, Ciardelli TL, Nissenson RA (1991) Analogues of parathyroid hormone modified at positions 3 and 6. J Biol Chem 266:1997-2004
13. Munson PJ, Rodbard D (1980) Ligand: a versatile computer approach for characterisation of ligand binding systems. Anal Biochem 107:220-239
14. Brennan DP, Levine MA (1987) Characterisation of soluble and particulate parathyroid hormone receptors using a biotinylated bioactive hormone analog. J Biol Chem 262:14795-14800
15. Schlüter K-D, Hellstern H, Wingender E, Mayer H (1989) The central part of parathyroid hormones stimulates thymidine incorporation of chondrocytes. J Biol Chem 264:11087-11092
16. Wozney J (1993) Bone morphogenetic proteins and their gene expression. In: Cellular and molecular biology of bone. Academic Press, New York, London, p 131
17. Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM, Siracusa LD, Lyons KM, Derynck R, Hogan BLM, Copeland NG, Jenkins NA (1990) Chromosomal localization of seven members of the murine TGF-β superfamily suggests close linkage to several morphogenetic mutant loci. Genomics 6:505-520
18. Plessow S, Köster M, Knochel W (1991) cDNA sequence of Xenopus laevis bone morphogenetic protein 2 (BMP-2). Biochim Biophys Acta 1089:280-282
19. Lyons K, Graycar JL, Lee A, Hashmi S, Lindquist PB, Chen EY, Hogan BLM, Derynck R (1998a) Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor β gene superfamily. Proc Natl Acad Sci USA 86:4554-4558
20. Özkaynak E, Schnegelsverg PNJ, Oppermann H (1991) Murine osteogenic protein (OP-1): high levels of mRNA in the kidney. Biochem Biophys Res Commun 179:116-123
21. Kingsley DM, Bland AE, Grubber JM, Marker PC, Russell LB, Copeland NG, Jenkins NA (1992) The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF-β superfamily. Cell 71:399-410
22. Storm EE, Huynh TV, Copeland NG, Jenkins NA, Kingsley DM, Lee S (1994) Limb alterations in brachypodism mice due to mutations in a new member of the TGF-β superfamily. Nature 368:639-643
23. Kingsley DM (1994) What do BMPs do in mammals? Clues from the mouse short-ear mutation. Trends Genet 10:16-21
24. Takuwa Y, Ohse C, Wang EA, Wozney JM, Yamashita K (1991) Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MT3T3-E1. Biochem Biophys Res Commun 174:96-101
25. Perides G, Safran RM, Downing LA, Chamess ME (1994) Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-β superfamily. J Biol Chem 269:7656-7670
26. Ahrens M, Ankenbauer T, Schröder D, Hollnagel A, Mayer H, Gross G (1993) Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages. DNA and Cell Biol 12:871-880
27. Ahrens M (1995) PhD-thesis, Technical University of Braunschweig, Braunchweig, Germany
28. Franzén P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin C-H, Miyazono K (1993) Cloning of a TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor. Cell 75:681-692
29. Lin HY, Wang X-F, Ng-Eaton E, Weinberg RA, Lodish HF (1992) Expression cloning of the TGF-β type II receptor, a functional transmembrane serin/threonine kinase. Cell 68:775-785
30. Attisano L, Cárcamo J, Ventura F, Weis FMB, Massagué J, Wrana JL (1993) Identification of human activin and TGF-β type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75:671-680
31. Pavalkar VM, Mammond RG, Reddi AH (1991) Identification and characterisation of cellular binding proteins (receptors) for recombinant human bone morphogenetic protein 2B, an initiator of bone differentiation cascade. Proc Natl Acad Sci USA 88:3397-3401
32. Estevez M, Attisano L, Wrana JL, Albert PS, Massagué J, Riddle DL (1993) The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature 365:644-649
33. Graff JM, Thies RS, Song JJ, Celeste AJ, Melton DA (1994) Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79:169-179
34. Lópes-Casillas F, Wrana JL, Massagué J (1993) Betaglycan presents ligand to the TGF-β signaling receptor. Cell 73:1435-1444
35. Cheifetz S, Hernandez H, Laiho M, ten Dijke P, Iwata KK, Massagué J (1990) Distinct transforming growth factor-β receptor subsets as determinants of cellular responsiveness to three TGF-β isoforms. J Biol Chem 265:20533-20538