1-arylnaphthalene lignan: A novel scaffold for type 5 phosphodiesterase inhibitor

Journal of Medicinal Chemistry

Volumn 42, Issue 7, 1999, Pages 1293-1305

  Ukita, Tatsuzo ^a   Nakamura, Yoshinori ^a   Kubo, Akira ^a   Yamamoto, Yasuo ^a   Takahashi, Masami ^a   Kotera, Jun ^a   Ikeo, Tomohiro ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 BROMO 4,5 DIMETHYLTHOXYPHENYL) 5 CHLORO 3 [4 (2 HYDROXYETHYL) 1 PIPERAZINYLCARBONYL] 2 (METHOXYCARBONYL)NAPHTHALENE HYDROCHLORIDE; 1 [CHLORO 4 [(3,4 METHYLENEDIOXYBENZYL)AMINO]QUINAZOLIN 2 YL]PIPERIDINE 3 CARBOXYLIC ACID SODIUM; LACTONE; LIGNAN DERIVATIVE; NAPHTHALENE DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG; ZAPRINAST;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; AORTA; CARDIOVASCULAR AGENTS; CORONARY VESSELS; DOGS; HEART; ISOENZYMES; LIGNANS; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; NAPHTHALENES; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0033535601     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9807048     Document Type: Article

References (18)

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