Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: Suppressed levels of a circulating marker for bile acid synthesis

Cancer Letters

Volumn 170, Issue 2, 2001, Pages 169-175

  Tatidis, Loukas ^a   Vitols, Sigurd ^a   Gruber, Astrid ^a   Paul, Christer ^b   Axelson, Magnus ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Acute myelogenous leukemia; Bile acids; Cholesterol; Low density lipoprotein

Indexed keywords

7 DEHYDROCHOLESTEROL; 7ALPHA HYDROXYCHOLEST 4 EN 3 ONE; BILE ACID; BIOCHEMICAL MARKER; CHOLESTEROL; KETONE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; BILE ACID SYNTHESIS; BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; EXCRETION; FEMALE; HUMAN; HUMAN CELL; HYPOCHOLESTEROLEMIA; INTESTINE ABSORPTION; LIPOLYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0035922201     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00592-4     Document Type: Article

References (28)

1. Hypocholesterolaemia in malignancy due to elevated low-density-lipoprotein-receptor activity in tumour cells: Evidence from studies in patients with leukaemia
2. Uptake of low density lipoproteins by human leukemic cells in vivo: Relation to plasma lipoprotein levels and possible relevance for selective chemotherapy
3. The possible prognostic usefulness of assessing serum proteins and cholesterol in malignancy
4. Serum cholesterol and human colon cancer
5. Elevated uptake of low density lipoproteins by human lung cancer tissue in vivo
6. Expression of the low-density lipoprotein receptor, HMG-CoA reductase, and multidrug resistance (Mdr1) genes in colorectal carcinomas
7. A receptor-mediated pathway for cholesterol homeostasis
8. Low density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells
9. Elevated low density lipoprotein receptor activity in leukemic cells with monocytic differentiation
10. Cholesterol, phospholipids, and fatty acids of normal immature neutrophils: Comparison with acute myeloblastic leukemia cells and normal neutrophils
11. Decreased feedback regulation of low density lipoprotein receptor activity by sterols in leukemic cells from patients with acute myelogenous leukaemia
12. Mechanisms of bile acid biosynthesis in mammalian liver
13. Levels of 7-alpha-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in man
14. The plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man
15. Serum concentrations of 7-alpha-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans
16. The level of 7-dehydrocholesterol in plasma reflects the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the human liver
17. Proposals for the classification of the acute leukaemias
18. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
19. The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia
20. Protein measurement with the Folin phenol reagent
21. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g
22. Occurrence of isomeric dehydrocholesterols in human plasma
23. S-phase DNA content and aneuploidy of immunophenotypic defined subpopulations in acute myeloid leukemia determined by multi-parameter flow cytometry
24. Macrophage-derived factors increase low density lipoprotein uptake and receptor number in cultured human liver cells
25. Evidence for internal autocrine regulation of growth in acute myeloblastic leukemia cells
26. A novel nonhepatic hydroxycholesterol 7 alpha-hydroxylase that is markedly stimulated by interleukin-1 beta. Characterization in the immature rat ovary
27. Potential bile acid precursors in plasma - Possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man
28. 27-Hydroxycholesterol: Production rates in normal human subjects