Restoring Proper Radical Generation by Azide Binding to the Iron Site of the E238A Mutant R2 Protein of Ribonucleotide Reductase from Escherichia coli

Journal of Biological Chemistry

Volumn 276, Issue 29, 2001, Pages 26852-26859

  Assarsson, Maria ^a   Andersson, Martin E ^a   Högbom, Martin ^a   Persson, Bert Ove ^a   Sahlin, Margareta ^a   Barra, Anne Laure ^b   Sjöberg, Britt Marie ^a   Nordlund, Pär ^a   Gräslund, Astrid ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; ENZYMES; ESCHERICHIA COLI; IRON; MUTAGENESIS; OXYGEN;

LIGANDS;

BIOCHEMISTRY;

AZIDE; IRON; LIGAND; MUTANT PROTEIN; OXYGEN; R2 PROTEIN; RADICAL; RIBONUCLEOTIDE REDUCTASE; UNCLASSIFIED DRUG; FREE RADICAL; TYROSINE;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME ISOLATION; ENZYME STRUCTURE; ESCHERICHIA COLI; LIGAND BINDING; OXYGEN AFFINITY; PRIORITY JOURNAL; REACTION ANALYSIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MUTAGENESIS; PROTEIN BINDING;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

AZIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; FREE RADICALS; IRON; MUTAGENESIS; PROTEIN BINDING; RIBONUCLEOTIDE REDUCTASES; SUBSTRATE SPECIFICITY; TYROSINE;

EID: 0035920191     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008190200     Document Type: Article

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