Effect of mutations in Gag on assembly of immature human immunodeficiency virus type 1 capsids in a cell-free system

Virology

Volumn 279, Issue 1, 2001, Pages 257-270

  Singh, Aalok R ^a,b   Hill, Rebecca L ^a   Lingappa, Jaisri R ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYSTEINE; GAG PROTEIN; HISTIDINE;

ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PHENOTYPE; PLASMID; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; VIRAL GENETICS; VIRUS ASSEMBLY; VIRUS CAPSID;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035915998     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0706     Document Type: Article

References (43)

1. Efficient particle production by minimal Gag constructs which retain the carboxy-terminal domain of human immunodeficiency virus type 1 capsid-p2 and a late assembly domain
2. Functional chimeras of the Rous sarcoma virus and human immunodeficiency virus Gag proteins
3. RNA packaging
4. The C-terminal half of the human immunodeficiency virus type 1 Gag precursor is sufficient for efficient particle assembly
5. Use of heterologous expression systems to study retroviral morphogenesis
6. Myristoylation-dependent replication and assembly of human immunodeficiency virus type 1
7. Human immunodeficiency virus type 1 MA deletion mutants expressed in baculovirus-infected cells: Cis and trans effects on the Gag precursor assembly pathway
8. The role of nucleocapsid of HIV-1 in virus assembly
9. Functional domains of the capsid protein of human immunodeficiency virus type 1
10. A large deletion in the matrix domain of the human immunodeficiency virus Gag gene redirects virus particle assembly from the plasma membrane to the endoplasmic reticulum
11. Specificity and sequence requirements for interactions between various retroviral Gag proteins
12. HIV-1 Gag proteins: Diverse functions in the virus life cycle
13. Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production
14. Recent advances and remaining problems in HIV assembly
15. Assembly and morphology of HIV: Potential effect of structure on viral function
16. Assembly and release of HIV-1 precursor Pr55Gag virus-like particles from recombinant baculovirus-infected insect cells
17. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1
18. Comparative morphology of Gag protein structures produced by mutants of the Gag gene of human immunodeficiency virus type 1
19. Assembly-defective point mutants of the human immunodeficiency virus type 1 Gag precursor phenotypically expressed in recombinant baculovirus-infected cells
20. Distinct signals in human immunodeficiency virus type 1 Pr55 necessary for RNA binding and particle formation
21. Intracellular transport of retroviral capsid components
22. Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristoylation signal
23. Formation of virus assembly intermediate complexes in the cytoplasm by wild-type and assembly-defective mutant human immunodeficiency virus type 1 and their association with membranes
24. Identification and characterization of virus assembly intermediate complexes in HIV-1-infected CD4+ cells
25. A multi-step, ATP-dependent pathway for assembly of human immunodeficiency virus (HIV) capsids in a cell-free system
26. A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle
27. Tables for estimating sedimentation through linear concentration gradients of sucrose solution
28. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
29. Characterization of human immunodeficiency virus type 1 matrix revertents: Effects on virus assembly, Gag processing, and env incorporation into virions
30. Efficient HIV-1 replication can occur in the absence of the viral matrix protein
31. Functional domains of HIV-1 Gag-polyproteins expressed in baculovirus-infected cells
32. Mapping and characterization of the N-terminal I domain of human immunodeficiency virus type 1 Pr55 Gag
33. The I domain is required for efficient plasma membrane binding of human immunodeficiency virus type 1 Pr55 Gag
34. Human immunodeficiency virus type 1 capsid formation in reticulocyte lysates
35. Identification of human immunodeficiency virus type 1 Gag protein domains essential to membrane binding and particle assembly
36. Assembly, processing, and infectivity of human immunodeficiency virus type 1 Gag mutants
37. Conditional infectivity of a human immunodeficiency virus matrix domain deletion mutant
38. Form, function and use of retroviral Gag proteins
39. Mutations in the N-terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor
40. Effects of nucleocapsid mutations on human immunodeficiency virus assembly and RNA encapsidation
41. Gag-Gag interactions in the C-terminal domain of human immunodeficiency virus type 1 p24 capsid antigen are essential for Gag particle assembly
42. Complementation of human immunodeficiency virus type 1 (HIV-1) Gag particle formation