Intracellular transport of retroviral capsid components

Current Topics in Microbiology and Immunology

Volumn 214, Issue , 1996, Pages 25-63

  Krausslich, H G ^a   Welker, R ^a  

^a LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; MATRIX PROTEIN; VIRUS PROTEIN;

HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRACELLULAR TRANSPORT; MEMBRANE VESICLE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN TARGETING; RETROVIRUS; REVIEW; STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS; VIRUS CAPSID; VIRUS CELL INTERACTION;

BIOLOGICAL TRANSPORT; CAPSID; HIV-1; HUMANS; RETROVIRIDAE; VIRUS ASSEMBLY; VIRUS INTEGRATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE; UNIDENTIFIED RETROVIRUS;

EID: 0030420089     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-80145-7_2     Document Type: Article

References (179)

1. Aboud M, Shoor R, Bari S, Hasan Y, Shurtz R, Malik Z, Salzberg S (1982) Biochemical analysis and electron microscopic study on intracellular virions in NIH/3T3 mouse cells chronically infected with Moloney murine leukemia virus: effect of interferon. J Gen Virol 62: 219-225
2. Aloia RC, Jensen FC, Curtain CC, Mobley PW, Gordon LM (1988) Lipid composition and fluidity of the human immunodeficiency virus Proc Natl Acad Sci USA 85: 900-904
3. Aloia RC, Tian H, Jensen FC (1993) Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes. Proc Natl Acad Sci USA 90 5181-5185
4. Arthur LO, Bess JW Jr, Sowder RC II, Benveniste RE, Mann DL, Chermann JC, Henderson LE (1992) Cellular proteins bound to immunodeficiency viruses: implications for pathogenesis and vaccines. Science 258 1935-1938
5. Bathurst IC, Chester N, Gibson HL, Dennis AF, Steimer KS, Barr PJ (1989) N myristylation of the human immunodeficiency virus type 1 gag polyprotein precursor in Saccharomyces cerevisiae. J Virol 63 3176-3179
6. Bennett RP, Nelle TD, Wills JW (1993) Functional chimeras of the Rous sarcoma virus and human immunodeficiency virus gag proteins J Virol 67. 6487-6498
7. Bilello JA, Wivel NA, Pitha PM (1982) Effect of interferon on the replication of mink cell focus inducing virus in murine cells, synthesis, processing, assembly, and release of viral proteins. J Virol 43 213-222
8. Biswas P, Polt G, Kinter AL, Justement JS, Stanley SK, Maury WJ, Bressler P, Orenstein JM, Fauci AS (1992) Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions of intracytoplasmic vacuoles in phorbol myristate acetate differentiated U1 cells. J Exp Med 176: 739-750
9. Blenis J, Resh MD (1993) Subcellular localization specified by protein acylation and phosphorylation. Curr Opin Cell Biol 5. 984-989
10. Bolognesi DP, Montelaro RC, Frank H, Schafer W (1978) Assembly of type C oncornaviruses. a model. Science 199: 183-186
11. Bour S, Schubert U, Peden K, Strebel K (1996) The envelope glycoprotein of human immunodeficiency virus type 2 has a Vpu-like activity that enhances viral particle release J Virol 70: 820-829
12. Bourinbaiar AS, Phillips DM (1991) Transmission of human immunodeficiency virus from monocytes to epithelia J Acquir Immune Defic Syndr 4: 56-63
13. Bowerman B, Brown PO, Bishop JM, Varmus HE (1989) A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev 3. 469-478
14. Bray M, Prasad S, Dubay WJ, Hunter E, Jeang K-T, Rekosh D, Hammarskjöld M-L (1994) A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. J Virol 91: 1256-1260
15. Brody BA, Rhee SS, Sommerfelt MA, Hunter E (1992) A viral protease mediated cleavage of the transmembrane glycoprotein of Mason Pfizer monkey virus can be suppressed by mutations within the matrix protein Proc Natl Acad Sci USA 89: 3443-3447
16. Brody BA, Rhee SS, Hunter E (1994) Postassembly cleavage of a retroviral glycoprotein cytoplasmic domain removes a necessary incorporation signal and activates fusion activity J Virol 68: 4620-4627
17. Bryant M, Ratner L (1990) Myristoylation dependent replication and assembly of human immunodeficiency virus 1. Proc Natl Acad Sci USA 87 523-527
18. Bugelski PJ, Maleeff BE, Klinkner AM, Ventre J, Hart TK (1995) Ultrastructural evidence of an interaction between Env and Gag proteins during assembly of HIV type 1. AIDS Res Hum Retroviruses 11: 55-64
19. Bukrinsky MI, Sharova N, Dempsey MP, Stanwick TL, Bukrinskaya AG, Haggerty S, Stevenson M (1992) Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Proc Natl Acad Sci USA 89: 6580-6584
20. Bukrinsky MI, Haggerty S, Dempsey MP, Sharova N, Adzhubel A, Spitz L, Lewis P, Goldfarb D, Emerman M, Stevenson M (1993a) A nuclear localization signal within HIV 1 matrix protein that governs infection of non dividing cells. Nature 365: 666-669
21. Bukrinsky MI, Sharova N, McDonald TL, Pushkarskaya T, Tarpley WG, Stevenson M (1993b) Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection. Proc Natl Acad Sci USA 90: 6125-6129
22. Burnette B, Yu G, Felsted RL (1993) Phosphorylation of HIV 1 gag proteins by protein kinase C J Biol Chem 268: 8698-8703
23. Burstein H, Bizub D, Skalka AM (1991) Assembly and processing of avian retroviral gag polyproteins containing linked protease dimers J Virol 65: 6165-6172
24. Campbell S, Vogt VM (1995) Self-assembly in vitro of purified CA-NC proteins from Rous sarcoma virus and human immunodeficiency virus type 1. J Virol 69: 6487-6497
25. Canivet M, Jouanny C, Fourcade A, Lasneret J, Rhodes-Feuillette A, Peries J (1983) Effect of human interferon on type D retroviruses multiplication in chronically infected cell lines. J Interferon Res 3: 53-64
26. Chatterjee S, Bradac JA, Hunter E (1982) Effect of monensin or Mason Pfizer monkey virus glycoprotein synthesis. J Virol 44. 1003-1012
27. Chazal N, Carriére C, Gay B, Boulanger P (1994) Phenotypic characterization of insertion mutants of the human immunodeficiency virus type 1 Gag precursor expressed in recombinant baculovirus-infected cells. J Virol 68: 111-122
28. Chazal N, Gay B, Carriére C, Tournier J, Boulanger P (1995) Human immunodeficiency virus type 1 MA deletion mutants expressed in baculovirus-infected cells: cis and trans effects on the Gag precursor assembly pathway. J Virol 69 365-375
29. Damsky CH, Sheffield JB, Tuszynski GP, Warren L (1977) Is there a role for actin in virus budding? J Cell Biol 75: 593-605
30. Delchambre M, Gheysen D, Thines D, Thiriart C, Jacobs E, Verdin E, Horth M, Burny A, Bex F (1989) The Gag precursor of simian immunodeficiency virus assembles into virus-like particles. EMBO J 8. 2653-2660
31. Deminie CA, Emerman M (1994) Functional exchange of an oncoretrovirus and a lentivirus matrix protein J Virol 68: 4442-4449
32. Dorfman T, Mammano F, Haseltine WA, Göttlinger HG (1994) Role of the matrix protein in the vinon association of the human immunodeficiency virus type 1 envelope glycoprotein. J Virol 68: 1689-1696
33. Edbauer CA, Naso RB (1983) Cytoskeleton associated Pr65gag and retrovirus assembly Virology 130. 415-426
34. Edbauer CA, Naso RB (1984) Cytoskeleton associated Pr65gag and assembly of retrovirus temperature sensitive mutants in chronically infected cells. Virology 134 389-397
35. Evans SS, Wang WC, Gregorio CC, Han T, Repasky EA (1993) Interferon-α alters spectrin organization in normal and leukemic human B lymphocytes. Blood 81: 759-766
36. Fäcke M, Janetzko A, Shoeman RL, Kràusslich HG (1993) A large deletion in the matrix domain of the human immunodeficiency virus gag gene redirects virus particle assembly from the plasma membrane to the endoplasmic reticulum. J Virol 67: 4972-4980
37. Fernie BF, Poli G, Fauci AS (1991) Alpha interferon suppresses virion but not soluble human immunodeficiency virus antigen production in chronically infected T lymphocytic cells. J Virol 65. 3968-3971
38. Fischer U, Huber J, Boelens WC, Mattaj IW, Luhrmann R (1995) The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82 475-483
39. Franke EK, Yuan HEH, Luban J (1994) Specific incorporation of cyclophilin A into HIV-1 virions. Nature 372 4972-4980
40. Freed EO, Martin MA (1994) HIV-1 infection of non-dividing cells. Nature 369. 107-108
41. Freed EO, Martin MA (1995) Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific single amino acid substitutions in the human immunodeficiency virus type 1 matrix. J Virol 69: 1984-1989
42. Freed EO, Orenstein JM, Buckler White AJ, Martin MA (1994) Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production. J Virol 68: 5311-5320
43. Freed EO, Englund G, Martin MA (1995) Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. J Virol 69: 3949-3954
44. Gallay P, Swingler S, Aiken C, Trono D (1995a) HIV-1 infection of nondividing cells: C-terminal phosphorylation of the viral matrix protein is a key regulator. Cell 80 379-388
45. Gallay P, Swingler S, Song J, Bushman F, Trono D (1995b) HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell 83: 569-576
46. Gallina A, Mantoan G, Rindi G, Milanesi G (1994) Influence of MA internal sequences, but not of the myristylated N-terminus sequence, on the binding site of HIV-1 Gag protein. Biochem Biophys Res Commun 204: 1031-1038
47. Garoff H, Wilschut J, Liljeström P, Wahlberg JM, Bron R, Suomalainen M, Smyth J, Salminen A, Barth BU, Zhao H et al (1994) Assembly and entry mechanisms of Semliki Forest virus. Arch Virol [Suppl] 9: 329-338
48. Gebhardt A, Bosch JV, Ziemiecki A, Friis RR (1984) Rous sarcoma virus p19 and gp35 can be chemically crosslinked to high molecular weight complexes: an insight into virus assembly J Mol Biol 174: 297-317
49. Gelderblom HR, Hausmann EH, Özel M, Pauli G, Koch MA (1987) Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins. Virology 156: 171-176
50. Gendelman HE, Baca L, Turpin JA, Kalter DC, Hansen BD, Orenstein JM, Friedman RM, Meltzer MS (1990) Restriction of HIV replication in infected T cells and monocytes by interferon alpha. AIDS Res Hum Retroviruses 6: 1045-1049
51. Gheysen D, Jacobs E, de Foresta F, Thiriart C, Francotte M, Thines D, De Wilde M (1989) Assembly and release of HIV 1 precursor Pr55gag virus like particles from recombinant baculovirus infected insect cells Cell 59: 103-112
52. Goepfert PA, Wang G, Mulligan MJ (1995) Identification of an ER retrieval signal in a retroviral glycoprotein. Cell 82: 543-544
53. González SA, Affranchino JL, Gelderblom HR, Burny A (1993) Assembly of the matrix protein of simian immunodeficiency virus into virus like particles. Virology 194: 548-556
54. Göttlinger HG, Sodroski JG, Haseltine WA (1989) Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 86: 5781-5785
55. Göttlinger HG, Dorfman, T, Cohen EA, Haseltine WA (1993) Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses Proc Natl Acad Sci USA 90: 7381-7385
56. Granowitz C, Goff SP (1994) Substitution mutations affecting a small region of the moloney murine leukemia virus MA Gag protein block assembly and release of virion particles. Virology 205: 336-344
57. Grief C, Farrar GH, Kent KA, Berger EG (1991) The assembly of HIV within the Golgi apparatus and Golgi derived vesicles of JM cell syncytia. AIDS 5: 1433-1439
58. Hansen M, Jelinek L, Whithing S, Barklis E (1990) Transport and assembly of Gag proteins into Moloney murine leukemia virus J Virol 64: 5306-5316
59. Hansen M, Jelinek L, Jones RS, Stegeman Olsen J, Barklis E (1993) Assembly and composition of intracellular particles formed by Moloney murine leukemia virus J Virol 67: 5163-5174
60. Hayakawa T, Miyazaki T, Misumi Y, Kobayashi M, Fujisawa Y (1992) Myristoylation-dependent membrane targeting and release of the HTLV-I Gag precursor, Pr53gag, in yeast. Gene 119: 273-277
61. Heine UL, Demsey AE, Tucker RW, Bykovsky AF (1985) Intracellular type A retrovirus movement associated with an intact microtubule system. J Gen Virol 66 275-282
62. Heinzinger NK, Bukrinsky MI, Haggerty SA, Ragland AM, Kewalramani V, Lee MA, Gendelman HE, Ratner L, Stevenson M, Emerman M (1994) The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells Proc Natl Acad Sci USA 91: 7311-7315
63. Henderson LE, Krutzsch HC, Oroszlan (1983) Myristyl amino-terminal acylation of murine retrovirus proteins: an unusual post-translational protein modification. Proc Natl Acad Sci USA 80: 339-343
64. Hill CP, Worthylake D, Bancroft DP, Christensen AM, Sundquist WI (1996) Crystal structures of the trimeric HIV-1 matrix protein, implications for membrane association and assembly Proc Natl Acad Sci USA 93 (in press)
65. Höner B, Shoeman RL, Traub P (1991) Human immunodeficiency virus type 1 protease microinjected into cultured human skin fibroblasts cleaves vimentin and affects cytoskeletal and nuclear architecture. J Cell Sci 100: 799-807
66. Hoshikawa N, Kojima A, Yasuda A, Takayashiki E, Masuko S, Chiba J, Sata T, Kurata T (1991) Role of the gag and pol genes of human immunodeficiency virus in hhe morphogenesis and maturation of retrovirus like particles expressed by recombinant vaccinia virus: an ultrastructural study. J Gen Virol 72: 2509-2517
67. Jacobs E. Gheysen D, Thines D, Francotte M, de Wilde M (1989) The HIV 1 Gag precursor Pr55gag synthesized in yeast is myristoylated and targeted to the plasma membrane Gene 79: 71-81
68. Jones TA, Blaug G, Hansen M, Barklis E (1990) Assembly of gag β-galactosidase proteins into retrovirus particles J Virol 64: 2265-2279
69. Johnston DS (1995) The intracellular localization of messenger RNAs Cell 81: 161-170
70. Jorgensen EC, Pedersen FS, Jorgensen P (1992) Matrix protein of Akv murine leukemia virus, genetic mapping of regions essential for particle formation. J Virol 66: 4479-4487
71. Kaplan AH, Swanstrom R (1991) Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartments. Proc Natl Acad Sci USA 88: 4528-4532
72. Kaplan AH, Zack JA, Knigge M, Paul DA, Kempf DJ, Norbeck DW, Swanstrom R (1993) Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles J Virol 67. 4050-4055
73. Kaplan AH, Manchester M, Swanstrom R (1994) The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release of occur with maximum efficiency. J Virol 68: 6782-6786
74. Karacostas V, Wolffe EJ, Nagashima K, Gonda MA, Moss B (1993) Overexpression of the HIV 1 gag pol polyprotein results in intracellular activation of HIV 1 protease and inhibition of assembly and budding of virus like particles Virology 193: 661-671
75. Kim J, Mosior M, Chung LA, Wu H, McLaughlin S (1991) Binding of peptides with basic residues to membranes containing acidic phospholipids. Biophys J 60: 135-148
76. Klikova M, Rhee SS, Hunter E, Ruml T (1995) Efficient in vivo assembly of retroviral capsids from gag precursor expressed in bacteria J Virol 69. 1093-1098
77. Klimkait T, Strebel K, Hoggan MD, Martin MA, Orenstein JM (1990) The human immunodeficiency virus type 1 specific protein vpu is required for efficient virus maturation and release J Virol 64: 621-629
78. Konvalinka J, Litterst MA, Welker R. Kottler H. Rippmann F, Heuser AM, Kràusslich HG (1995a) An active-site mutation in the human immunodeficiency virus type 1 proteinase (PR) causes reduced PR activity and loss of PR-mediated cytotoxicity without apparent effect on virus maturation and infectivity J Virol 69. 7180-7186
79. Konvalinka J, Löchelt M, Zentgraf H, Flügel RM, Kräusslich HG (1995b) Active foamy virus proteinase is essential for virus infectivity but not for formation of a Pol polyprotein J Virol 69: 7264-7268
80. Kräusslich HG (1991) Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity. Proc Natl Acad Sci USA 88 3213-3217
81. Kräusslich HG (1992) Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single chain proteinase dimer and restores particle formation. J Virol 66: 567-572
82. Kräusslich HG, Fàcke M, Heuser AM, Konvalinka J, Zentgraf H (1995) The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity. J Virol 69. 3407-3419
83. Kräusslich HG, Pawlita M, Hunter E, Zentgraf H (1996) The budding type of squirrel monkey retrovirus is influenced by the host cell (submitted for publication)
84. Kuff EL, Lueders KK (1988) The intracisternal A particle gene family: structure and functional aspects. Adv Cancer Res 51: 183-276
85. Lawrence JB, Singer RH, Marselle LM (1989) Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization. Cell 57. 493-502
86. Lawrence JB, Marselle LM, Byron KS, Johnson CV, Sullivan JL, Singer RH (1990) Subcellular localization of low-abundance human immunodeficiency virus nucleic acid sequences visualized by fluorescence in situ hybridization. Proc Natl Acad Sci USA 87: 5420-5424
87. Lee PP, Linial ML (1994) Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal J Virol 68: 6644-6654
88. Leis J, Phillips N, Fu X, Tuazon PT, Traugh JA (1989) Phosphorylation of avian retrovirus matrix protein by Ca2+/phospholipid dependent protein kinase. Eur J Biochem 179. 415-422
89. Löchelt M, Flügel RM (1996) The human foamy virus pol gene is expressed as a Pro-Pol polyprotein and not as a Gag-Pol fusion protein. J Virol 70. 1033-1040
90. Lodge R, Göttlinger H, Gabuzda D, Cohen EA, Lemay G (1994) The intracytoplasmic domain of gp41 mediates polarized budding of human immunodeficiency virus type 1 in MDCK cells J Virol 68: 4857-4861
91. Lu YL, Spearman P, Ratner L (1993) Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions. J Virol 67 6542-6550
92. Luban J, Bossolt KL, Franke EK, Kalpana GV, Goff SP (1993) Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell 73 1067-1078
93. Luftig RB, Lupo LD (1994) Viral interactions with the host cell cytoskeleton, the role of retroviral proteases Trends Microbiol 2: 178-182
94. Mak J, Jiang M, Wainberg MA, Hammarskjold ML, Rekosh D, Kleiman L (1994) Role of Pr160gag pol in mediating the selective incorporation of tRNA(Lys) into human immunodeficiency virus type 1 particles. J Virol 68: 2065-2072
95. Mammano F, Kondo E, Sodroski J, Bukovsky A, Göttlinger HG (1995) Rescue of human immunodeficiency virus type 1 matrix protein mutants by envelope glycoproteins with short cytoplasmic domains. J Virol 69: 3824-3830
96. Massiah MA, Stanch MR, Paschall C, Summers MF, Christensen AM, Sundquist WI (1994) Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein J Mol Biol 244: 198-223
97. Matthews S, Barlow P, Boyd J, Barton G, Russell R, Mills H, Cunningham M, Meyers N, Burns N, Clark N et al (1994) Structural similarity between the p17 matrix protein of HIV 1 and interferon gamma. Nature 370: 666-668
98. McLauglin S, Aderem A (1995) The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. TIBS 20 272-276
99. Mergener K, Fäcke M, Welker R, Brinkmann V, Gelderblom HR, Krausslich HG (1992) Analysis of HIV particle formation using transient expression of subviral constructs in mammalian cells. Virology 186 25-39
100. Morikawa Y, Kishi T, Zhang WH, Nermut M, Hockley DJ, Jones IM (1995) A molecular determinant of human immunodeficiency virus particle assembly located in matrix antigen p17 J Virol 69. 4519-4523
101. Nash MA, Meyer MK, Decker GL, Arlinghaus RB (1993) A subset of Pr65gag is nucleus associated in murine leukemia virus infected cells J Virol 67: 1350-1356
102. Niedrig M, Gelderblom HR, Pauli G. Marz J, Bickhard H, Wolf H, Modrow S (1994) Inhibition of infectious human immunodeficiency virus type 1 particle formation by Gag protein derived peptides J Gen Virol 75: 1469-1474
103. Nieva JL, Bron R, Corver J, Wilschut (1994) Membrane fusion of Semliki Forest virus requires sphingolipids in the target membrane. EMBO J 13: 2797-2804
104. Oka T, Ohtsuki Y, Sonobe H, Furihata M, Miyoshi (1990) Suppressive effects of interferons on the production and release of human T-lymphotropic virus-I (HTLV-I). Arch Virol 115 63-73
105. Orenstein JM (1992) Immunodeficiency virus infection. Ultrastruct Pathol 16: 179-210
106. Orenstein JM, Meltzer MS, Phipps T, Gendelman HE (1988) Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony stimulating factor 1 treated human monocytes: an ultrastructural study. J Virol 62: 2578-2586
107. Owens RJ, Compans RW (1989) Expression of the human immunodeficiency virus envelope glycoprotein is restricted to basolateral surfaces of polarized epithelial cells. J Virol 63: 978-982
108. Owens RJ, Dubay JW, Hunter E, Compans RW (1991) Human immunodeficiency virus envelope protein determines the site of virus release in polarized epithelial cells Proc Natl Acad Sci USA 88: 3987-3991
109. Pal R, Reitz MS Jr, Tschachler E, Gallo RC, Sarngadharan MG, Veronese FD (1990) Myristoylation of gag proteins of HIV 1 plays an important role in virus assembly AIDS Res Hum Retroviruses 6: 721-730
110. Pal R, Mumbauer S, Hoke GM, Takatsuki A, Sarngadharan MG (1991) Brefeldin A inhibits the processing and secretion of envelope glycoproteins of human immunodeficiency virus type 1 AIDS Res Hum Retroviruses 7: 707-712
111. gag and is incorporated into viruslike particles J Virol 66. 6304-6313
112. Pautrat G, Suzan M, Salaun D, Corbeau P, Allasia C, Morel G, Filippi P (1990) Human immunodeficiency virus type 1 infection of U937 cells promotes cell differentiation and a new pathway of viral assembly Virology 179: 749-758
113. Pearce-Pratt R, Malamud D, Phillips DM (1994) Role of the cytoskeleton in cell-to-cell transmission of human immunodeficiency virus J Virol 68: 2898-2905
114. Peitzsch RM, McLaughlin S (1993) Binding of acylated peptides and fatty acids to phospholipid vesicles: relevance to myristoylated proteins. Biochemistry 32: 10436-10443
115. Peng C, Ho BK, Chang TW, Chang NT (1989) Role of human immunodeficiency virus type 1 specific protease in core protein maturation and viral infectivity J Virol 63: 2550-2556
116. Pepinsky RB, Vogt VM (1979) Identification of retrovirus matrix proteins by lipid protein cross-linking. J Mol Biol 131: 819-837
117. Pepinsky RB, Vogt VM (1984) Fine-structure analyses of lipid-protein and protein-protein interactions of gag protein p19 of the avian sarcoma and leukemia viruses by cyanogen bromide mapping J Virol 52: 145-153
118. Pessin JE, Glaser M (1983) Budding of Rous sarcoma virus and vesicular stomatitis virus from localized lipid regions in the plasma membrane of chicken embryo fibroblasts. J Biol Chem 255: 9044-9050
119. Pfeffer LM, Landsberger FR (1990) Interferon-α modulates the plasma membrane-cytosketetal complex of human lymphoblastoid cells sensitive to the antiproliferative action of interferon-α. J Interferon Res 10: 91-97
120. Pfeffer LM, Wang E, Tamm I (1980) Interferon inhibits the redistribution of cell surface components J Exp Med 152 469-474
121. Pfeffer LM, Landsberger FR, Tamm I (1981) β-Interferon-induced time-dependent changes in the plasma membrane lipid bilayer of cultured cells J Interferon Res 1 613-620
122. Phillips DM, Bourinbaiar AS (1992) Mechanism of HIV spread from lymphocytes to epithelia. Virology 186 261-273
123. Phillips DM, Tan X (1992) HIV-1 infection of the trophoblast cell line BeWo: a study of virus uptake AIDS Res Hum Retroviruses 8 1683-1691
124. Pitha PM, Bilello JA, Riggin CH (1981) Effect of interferon on retrovirus replication. Tex Rep Biol Med 41. 603-609
125. Poli G, Orenstein JM, Kinter A, Folks TM, Fauci AS (1989) Interferon alpha but not AZT suppresses HIV expression in chronically infected cell lines. Science 244: 575-577
126. Pumplin DW, Bloch RJ (1993) The membrane skeleton. Trends Cell Biol 3: 113-117
127. Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI (1995) Crystal structure of SIV matrix antigen and implications for virus assembly. Nature 238: 743-747
128. Reicin AS, Paik S, Berkowitz RD, Luban J, Lowy I, Goff SP (1995) Linker insertion mutations in the human immunodeficiency virus type 1 gag gene, effects on virion particle assembly, release, and infectivity J Virol 69. 642-650
129. Rein A, McClure MR, Rice NR, Luftig RB, Schultz AM (1986) Myristylation site in Pr65gag is essential for virus particle formation by Moloney murine leukemia virus Proc Natl Acad Sci USA 83: 7246-7250
130. Rhee SS, Hunter E (1987) Myristylation is required for intracellular transport but not for assembly of D type retrovirus capsids J Virol 61. 1045-1053
131. Rhee SS, Hunter E (1990a) Structural role of the matrix protein of type D retroviruses in gag polyprotein stability and capsid assembly. J Virol 64. 4383-4389
132. Rhee SS, Hunter E (1990b) A single amino acid substitution within the matrix protein of a type D retrovirus converts its morphogenesis to that of a type C retrovirus. Cell 63: 77-86
133. Rhee SS, Hunter E (1991) Amino acid substitutions within the matrix protein of type D retroviruses affect assembly, transport and membrane association of a capsid. EMBO J 10: 535-546
134. Royer M, Cerutti M, Gay B, Hong SS, Devauchelle G, Boulanger P (1991) Functional domains of HIV 1 gag polyprotein expressed in baculovirus infected cells. Virology 184: 417-422
135. Royer M, Hong SS, Gay B, Cerutti M, Boulanger P (1992) Expression and extracellular release of human immunodeficiency virus type 1 Gag precursors by recombinant baculovirus infected cells. J Virol 66. 3230-3235
136. Sagara J, Tsukita S, Yonemura S, Tsukita S, Kawai A (1995) Cellular actin-binding ezrin-radixin-moesin (ERM) family proteins are incorporated into the rabies virion and closely associated with envelope proteins in the cell. Virology 206: 485-494
137. Satake M, Luftig RB (1982) Microtubule-depolymerizing agents inhibit Moloney murine leukemia virus production J Gen Virol 58: 339-349
138. Schätzl H, Gelderblom HR, Nitschko H, von der Helm K (1991) Analysis of non-infectious HIV particles produced in presence of HIV proteinase inhibitor. Arch Virol 120: 71-81
139. Schltephake AW, Rethwilm A (1994) Nuclear localization of foamy virus Gag precursor protein. J Virol 68: 4946-4954
140. Schubert U, Bour S, Ferrer-Montiel A, Montai M, Maldarelli F, Strebel K (1996a) The two biological activities of the human immunodeficiency virus type-1 Vpu protein involve two separate structural domains J Virol 70: 809-819
141. Schubert U, Henklein P, Ferrer-Montiel AV, Oblatt-Montal M, Strebel K, Montal M (1996b) Identification of an ion channel activity of the Vpu transmembrane domain and its function in the regulation of virus release from HIV-1 infected cells (submitted for publication)
142. Schultz AM, Henderson LE, Oroszlan S (1988) Fatty acylation of proteins. Annu Rev Cell Biol 4: 611-647
143. Schultz AM, Rein A (1989) Unmyristylated Moloney murine leukemia virus Pr65gag is excluded from virus assembly and maturation events. J Virol 63: 2370-2373
144. Sen GC, Pinter A (1983) Interferon-mediated inhibition of production of Gazdar murine sarcoma virus, a retrovirus lacking env proteins and containing an uncleaved gag precursor. Virology 126: 403-407
145. Shoeman RL, Höner B, Stoller TJ, Kesselmeier C, Miedel MC, Traub P, Graves MC (1990) Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein. Proc Natl Acad Sci USA 87: 6336-6340
146. Shoeman RL, Kesselmeier C, Mothes E, Höner B. Traub P (1991) Non viral cellular substrates for human immunodeficiency virus type 1 protease FEBS Lett 278: 199-203
147. Simons K, van Meer G (1988) Lipid sorting in epithelial cells. Biochemistry 27: 6197-6202
148. Smith AJ, Srinivasakumar N, Hammarskjold ML, Rekosh D (1993) Requirements for incorporation of Pr160gag pol from human immunodeficiency virus type 1 into virus like particles. J Virol 67: 2266-2275
149. Smith MS, Thresher RJ, Pagano JS (1991) Inhibition of human immunodeficiency virus type 1 morphogenesis in T cells by alpha interferon. Antimicrob Agents Chemother. 35. 62-67
150. Spearman P, Wang JJ, Vander Heyden N, Ratner L (1994) Identification of human immunodeficiency virus type 1 Gag protein domains essential to membrane binding and particle assembly J Virol 68: 3232-3242
151. Srinivasakumar N, Hammarskjold ML, Rekosh D (1995) Characterization of deletion mutations in the capsid region of human immunodeficiency virus type 1 that affect particle formation and Gag-Pol precursor incorporation J Virol 69: 6106-6114
152. Taniguchi H, Manenti S (1993) Interaction of myristoylated alanina-rich protein kinase C substrate (MARCKS) with membrane phosphohpids. J Biol Chem 268: 9960-9963
153. Terwilliger EF, Cohen EA, Lu YC, Sodroski JG, Haseltine WA (1989) Functional role of human immunodeficiency virus type 1 vpu Proc Natl Acad Sci USA 86. 5163-5167
154. Thali M, Bukovsky A, Kondo E, Rosenwirth B, Walsh C, Sodroski J, Göttlinger HG (1994) Functional association of cyclophilin A with HIV-1 virions Nature 372: 363-365
155. Thelen M, Rosen A, Nairn AC, Aderem A (1991) Regulation by phosphorylatton of reversible association of myristoylated protein kinase C substrate with the plasma membrane. Nature 351: 320-322
156. Ulmer JB, Palade GE (1991) Effects of Brefeldin A on the Golgi complex, endoplasmic reticulum and viral envelope glycoproteins in murine erythroleukemia cells Eur J Cell Biol 54. 38-54
157. Vieillard V, Lauret E, Rousseau V, de Maeyer E (1994) Blocking of retroviral infection at a step prior to reverse transcription in cells transformed to constitutively express interferon beta. Proc Natl Acad Sci USA 91: 2689-2693
158. Vlasuk GP, Waxman L, Davis LJ, Dixon RA, Schultz LD, Hofmann KJ, Tung JS, Schulman CA, Ellis RW, Bencen GH, et al (1989) Purification and characterization of human immunodeficiency virus (HIV) core precursor (p55) expressed in Saccharomyces cerevisiae. J Biol Chem 264: 12106-12112
159. von Schwedler U, Kornbluth RS, Trono D (1994) The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. Proc Natl Acad Sci USA 91: 6992-6996
160. Wagner R, Demi L, Fliessbach H, Wanner G, Wolf H (1994) Assembly and extracellular release of chimeric HIV-1 Pr55gag retrovirus-like particles Virology 200: 162-175
161. Wang CT, Barklis E (1993) Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants. J Viral 67: 4264-4273
162. Wang CT, Zhang Y, McDermott J, Barklis E (1993) Conditional infectivity of human immunodeficiency virus matrix domain deletion mutant. J Virol 67: 7067-7076
163. Wang CT, Stegeman Olsen J, Zhang Y, Barklis E (1994) Assembly of HIV GAG β galactosidase fusion proteins into virus particles. Virology 200: 524-534
164. Wang E, Wolf BA, Lamb RA, Choppin PW, Goldberg AR (1976) The presence of actin in enveloped viruses. In: Goldman R. Pollard T, Rosenbaums J (eds) Cell motility Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 589-599
165. 3 cells in suspension culture Proc. Natl. Acad Sc. USA 8: 6281-6285
166. Weaver TA, Panganiban AT (1990) N myristoylation of the spleen necrosis virus matrix protein is required for correct association of the Gag polyprotein with intracellular membranes and for particle formation. J Virol 64: 3995-4001
167. Weldon RA Jr, Erdie CR, Oliver MG, Wills JW (1990) Incorporation of chimeric gag protein into retroviral particles. J Virol 64: 4169-4179
168. Welker R, Janetzko A, Kräusslich HG (1996) Plasma membrane targeting of intracisternal A type particle polyproteins leads to particle release and specifically activates the viral proteinase (submitted for publication)
169. Wen W, Meinkoth JL, Tsien RY, Taylor SS (1995) Identification of a signal for rapid export of proteins from the nucleus Cell 82: 463-473
170. Wills JW, Craven RC (1991) Form, function, and use of retroviral Gag proteins. AIDS 5: 639-654
171. Wills JW, Craven RC, Achacoso JA (1989) Creation and expression of myristylated forms of Rous sarcoma virus gag protein in mammalian cells J Virol 63: 4331-4343
172. Wills JW, Craven RC, Weldon RA Jr, Nelle TD, Erdie CR (1991) Suppression of retroviral MA deletions deletions by the amino terminal membrane binding domain of p60src. J Virol 65: 3804-3812
173. Yu G, Shen FS, Sturch S, Aquino A, Glazer RI, Felsted RL (1995) Regulation of HIV-1 gag protein subcellular targeting by protein kinase C. J Biol Chem 270: 4792-4796
174. Yu SF, Baldwin DN, Gwynn SR, Yandapalli S, Linial M (1996) Human foamy virus replication, a pathway distinct from that of retroviruses and hepadnaviruses. Science 271: 1579-1582
175. Yu X, Yu QC, Lee TH, Essex M (1992a) The C terminus of human immunodeficiency virus type 1 matrix protein is involved in early steps of the virus life cycle. J Virol 66: 5667-5670
176. Yu X, Yuan X, Matsuda Z, Lee TH, Essex M (1992b) The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions. J Virol 66: 4966-4971
177. Yuan X, Yu X, Lee TH, Essex M (1993) Mutations in the N terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor. J Virol 67: 6387-6394
178. Zhou W, Parent LJ, Wills JW, Resh MD (1994) Identification of a membrane binding domain within the amino terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids J Virol 68: 2556-2569
179. Zolotukhin AS, Valentin A, Pavlakis GN, Felber BK (1994) Continuous propagation of RRE(-) and Rev(-) RRE(-) human immunodeficiency type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes. J Virol 68: 7944-7952