Gag-Gag interactions in the C-terminal domain of human immunodeficiency virus type 1 p24 capsid antigen are essential for Gag particle assembly

Journal of General Virology

Volumn 77, Issue 4, 1996, Pages 743-751

  Zhang, Wei Hong ^a   Hockley, David J ^b   Nermut, Milan V ^b   Morikawa, Yuko ^c   Jones, Ian M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^c KITASATO INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; GAG PROTEIN; MUTANT PROTEIN; PROTEIN PRECURSOR; VIRUS CAPSID ANTIGEN;

AMINO ACID SEQUENCE; ARTICLE; BACULOVIRUS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; VIRUS ASSEMBLY; VIRUS RECOMBINANT;

EID: 0030007245     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-77-4-743     Document Type: Article

References (49)

1. CARRIERE, C., GAY, B., CHAZAL, N., MORIN, N. & BOULANGER, P. (1995). Sequence requirements for encapsidation of deletion mutants and chimeras of human immunodeficiency virus type 1 Gag precursor into retrovirus-like particles Journal of Virology 69, 2366-2377
2. CHAZAL, N., CARRIERE, H. B., GAY, B. & BOULANGER, P. (1994). Phenotypic characterization of insertion mutants of the human immunodeficiency virus type 1 gag precursor expressed in recombinant baculovirus-infected cells. Journal of Virology 68, 111-122.
3. CHAZAL, N., GAY, B., CARRIERE, C., TOURNER, J. & BOULANGER, P. (1995). Human immunodeficiency virus type I MA deletion mutants expressed in baculovirus-infected cells: cis and trans effects on Gag precursor assembly pathway. Journal of Virology 69, 365-375.
4. DEMINIE, C. A. & EMERMAN, M. (1993). Incorporation of human immunodeficiency virus type 1 gag proteins into murine leukemia virus virions Journal of Virology 67, 6499-6506.
5. DORFMAN, T., BUKOVSKY, A., O'HAGEN, A., HOGLUND, S. & GOTT-LINGER, H. G. (1994). Functional domains of the capsid protein of human immunodeficiency virus type 1. Journal of Virology 68, 8180-8187.
6. EHRLICH, L. S., AGRESTA, B. E. & CARTER, C. A. (1992). Assembly of human immunodeficiency virus type 1 capsid protein in vitro. Journal of Virology 66, 4874-4883
7. EHRLICH, L. S., AGRESTA, B. E., GELFAND, C. A., JENTOFT, J. & CARTER, C. A. (1994). Spectral analysis and tryptic susceptibility as probes of HIV-1 capsid protein structure. Virology 204, 515-525.
8. FRANKE, E. K., YUAN, H. E. & LUBAN, J. (1994a). Specific incorporation of cyclophilin A into HIV-1 virions. Nature 372, 359-362.
9. FRANKE, E. K., EN, H., YUAN, H., BOSSOLT, K. L., GOFF, S. P. & LUBAN, J. (1994b). Specificity and sequence requirements for interactions between various retroviral Gag proteins. Journal of Virology 68, 5330-5334.
10. FREED, E. O., ORENSTEIN, J. M., BUCKLER-WHITE, A. J. & MARTIN, M. A. (1994). Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production. Journal of Virology 68, 5311-5320.
11. GHEYSEN, D., JACOBS, E., DE FORESTA, F., THIRIART, C., FRANCOTTE, M., THINES, D. & WILDE, M. D. (1989). Assembly and release of HIV-1 precursor pr55gag virus-like particles from recombinant baculovirus-infected insect cells. Cell 59, 103-112.
12. GILMOUR, J. E., SENIOR, J M., BURNS, N. R., ESNOUF, M. P., GULL, K., KINGSMAN, S. M., KINGSMAN, A. J. & ADAMS, S. E. (1989). A novel method for the purification of HIV-1 p24 protein from hybrid Ty virus-like particles (Ty-VLPs). AIDS 3, 717-723.
13. GOTTLINGER, H. G., DORFMAN, T., SODROSKI, J. G. & HASELTINE, W. A. (1991). Effects of mutations affecting the p6 Gag protein on human immunodeficiency virus particle release Proceedings of the National Academy of Sciences, USA 88, 3195-3199.
14. GRASSER, F. A., SAUDER, C., HAISS, P., HILLE, A., KONIG, S., GOTTEL, S., KREMMER, E., LEINENBACK, H. P., ZEPPEZAUER, M. & MUELLER-LANTZSCH, N. (1993). Immunological detection of proteins associated with the Epstein-Barr virus nuclear antigen 2A. Virology 195, 550-560.
15. HOCKLEY, D. J., NERMUT, M. V., GRIEF, C., JOWETT, J. B. M. & JONES, I M. (1994). Comparative morphology of Gag protein structures produced by mutants of the gag gene of human immunodeficiency virus type 1. Journal of General Virology 75, 2985-2997.
16. HONG, S.S. & BOULANGER, P. (1993). Assembly-defective point mutants of the human immunodeficiency virus type 1 Gag precursor phenotypically expressed in recombinant baculovirus-infected cells. Journal of Virology 67, 2787-2798.
17. HOSHIKAWA, N., KOJIMA, A., YASUDA, A., TAKAYASHIKI, E., MUSAKO, S., CHIBA, J., SATA. T. & KURATA, T (1991). Role of the gag and pol genes of human immunodeficiency virus in the morphogenesis and maturation of retrovirus-like particles expressed by recombinant vaccinia virus: an ultrastructural study. Journal of General Virology 72, 2501-2517.
18. HU, S.-L., TRAVIS, B., GARRIGUES, J., ZARLING, J. M., SRIDHAR, P., DYKERS, T., EICHBERG, J.E. & ALPERS. C. (1990). Processing. assembly and immunogenicity of human immunodeficiency virus core antisens expressed by recombinant vaccinia virus. Virology 179, 321-329.
19. JOWETT, J. B. M., HOCKLEY, D. J., NERMUT, M. & JONES, I. M. (1992). Distinct signals in human immunodeficiency virus type 1 Pr55 necessary for RNA binding and particle formation. Journal of General Virology 73, 3079-3086.
20. KAPLAN, A. H., MANCHESTER, M. & SWANSTROM, R. (1994). The activity of the protease of human immunodeficiency virus type I is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency. Journal of Virology 68, 6782-6786.
21. KITTS, P., AYRES, M. & POSSEE, R. (1991). Linearisation of baculovirus DNA improves the selection of recombinant transfer vectors. Nucleic Acids Research 18, 5667-5672.
22. KRAUSSLICH, H.-G., FACKE, M., HEUSER, A.-M., KONVALINKA, J. & ZENTGRAF, H. (1995). The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity. Journal of Virology 69, 3407-3419.
23. LIVINGSTONE, C. & JONES, I. M. (1989). Baculovirus expression vectors with single-strand capability. Nucleic Acids Research 17, 2366
24. LUBAN, J., LEE, C. & GOFF, S. P. (1993). Effect of linker insertion mutations in the human immunodeficiency virus type 1 gag gene on activation of viral protease expressed in bacteria. Journal of Virology 67, 3630-3634.
25. MAMMANO, F., O'HAGEN, A., HOGLUND, S. & GOTTLINGER, H. G. (1994). Role of major homology region of human immunodeficiency virus type 1 in virion morphogenesis. Journal of Virology 68, 4927-4936.
26. MASSIAH, M. A., STARICH, M. R., PASCHALL, C. M., SUMMERS, M. F., CHRISTENSEN, A. M. & SUNDQUIST, W. I. (1994). Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein. Journal of Molecular Biology 244, 194-223.
27. MATTHEWS, S., BARLOW, P., BOYD J., BARTON, G., RUSSELL, R., MILLS, H., CUNNINGHAM, M., MEYERS, N., BURNS, N., CLARK, N., KINGSMAN, S., KINGSMAN, A. & CAMPBELL, I. (1994). Structural similarity between the p17 matrix protein of HIV-1 and Interferon gamma. Nature 370, 666-668.
28. MERGENER, K., FACKE, M., WELKER, R., BRINKMAN, V., GELDERBLOM, H. R. & KRAUSSLICH, H. G. (1992). Analysis of HIV particle formation using transient expression of subviral constructs in mammalian cells. Virology 186, 25-39.
29. MILLS, H. R. & JOKES, I. M. (1990). Expression and purification of p24, the core protein of human immunodeficiency virus, using a baculovirus-insect cell expression system. AIDS 4, 1125-1131.
30. MILLS, H. R., BERRY, N., BURNS, N. R. & JONES, I. M. (1992). Simple and efficient production of the core antigens of HIV-1. HIV-2 and simian immunodeficiency virus using pGEX expression vectors in Escherichia coli. AIDS 6, 437-439.
31. MORIKAWA, Y., KISHI, T., ZHANG, W.-H., NERMUT, M. V., HOCKLEY, D. J. & JONES, I. M. (1995). A molecular determinant of HIV particle assembly located in the matrix antigen p17. Journal of Virology 69, 4519-4523.
32. NERMUT, M. V., HOCKLEY, D. J., JOWETT, J. B. M., JONES, I. M., GARREAU, M. & THOMAS, D. (1994). Fullerene-like organization of HIV Gag-protein shell in virus-like particles produced by recombinant baculoviruses. Virology 198, 288-296.
33. NIEDRIG, M., GELDERBLOM, H R., PAULI, G., MARZ, J., BICKHARD, H., WOLF, H. & MODROW, S. (1994). Inhibition of infectious human immunodeficiency virus type 1 particle formation by Gag protein-derived peptides. Journal of General Virology 75, 1469-1474.
34. O'REILLY, D. R., MILLER, L. K. & LUCKOW, V. A. (1992). Baculovirus Expression Vectors: A Laboratory Manual, 1st edn. New York: W. H. Freeman.
35. OVERTON, H A., FUJII, Y., PRICE, I. R. & JONES, I. M. (1989) The protease and gag gene products of the human immunodeficiency virus: authentic cleavage and post-translational modification in an insect cell expression system. Virology 170, 107-116.
36. PAXTON, W., CONNOR, R. I. & LANDAU, N. R. (1993). Incorporation of vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of Gag and mutational analysis. Journal of Virology 67, 7229-7237.
37. PETTIT, S. C., MOODY, M D., WEHBIE, R. S., KAPLAN, A. H., NANTERMET, P. V., KLEIN, C. A. & SWANSTROM, R. (1994). The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions. Journal of Virology 68, 8017-8027.
38. POBLOTZKI, A V., WAGNER, R., NIEDRIG, M., WANNER, G., WOLF, H. & MODROW, S. (1993). Identification of a region in the Pr55gag polyprotein essential for HIV-1 particle formation. Virology 193, 981-986.
39. REICIN, A. S., PAIK, S., BERKOWITZ, R. D., LUBAN, J., LOWY, I. & GOFF, S. P. (1995). Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release and infectivity. Journal of Virology 69, 642-650.
40. ROYER, M., CERUTTI, M., GAY, B., HONG, S.-S., DEVAUCHELLE, G. & BOULANGER, P. (1991). Functional domains of HIV-1 Gag-polyprotein expressed in baculovirus-infected insect cells. Virology 184, 417-422.
41. ROYER, M., HONG, S. S., GAY, B., CERUTTI, M. & BOULANGER, P. (1992). Expression and extracellular release of human immunodeficiency virus type 1 Gag precursors by recombinant baculovirus-infected cells. Journal of Virology 66, 3230-3235.
42. THALI, M., BUKOVSKY, A., KONDO, E., ROSENWIRTH, B., WALSH, C. T., SODROSKI, J. & GOTTLINGER, H. G. (1994). Functional association of cyclophilin A with HIV-1 virions. Nature 372, 363-365.
43. TRONO, D., FEINBERG, M. B. & BALTIMORE, D. (1989). HIV-1 gag mutants can dominantly interfere with the replication of the wild-type virus. Cell 59, 113-320.
44. VERONESE, F. D., COPELAND, T. D., OROSZLAN, S., GALLO, R. C. & SARNGADHARAN, M. G. (1988). Biochemical and immunological analysis of human immunodeficiency virus gag gene products p17 and p24. Journal of Virology 62, 795-801.
45. WANG, C. T. & BARKLIS, E. (1993). Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants. Journal of Virology 67, 4264-4273.
46. WILLS, J. W. & CRAVEN, R. C. (1991). Form, function and use of retroviral Gag proteins AIDS 5, 639-654.
47. ZHANG, W.-H., HOCKLEY, D J., NERMUT, M. V. & JONES, I. M. (1994). Functional consequences of mutations in HIV-1 gag p55 selected by CTL pressure. Virology 203, 101-105
48. ZHAO, Y., JONES, I. M., HOCKLEY, D. J., NERMUT, M. V. & ROY, P. (1994). Complementation of human immunodeficiency virus (HIV-1) gag particle formation. Virology 199, 403-408.
49. ZYBARTH, G. & CARTER, C. (1995). Domains upstream of the protease (PR) in human immunodeficiency virus type 1 gag-pol influence PR autoprocessing. Journal of Virology 69, 3878-3884.