Mapping and characterization of the N-terminal I domain of human immunodeficiency virus type 1 Pr55(Gag)

Journal of Virology

Volumn 74, Issue 16, 2000, Pages 7238-7249

  Sandefur, S ^a   Smith, R M ^a   Varthakavi, V ^a   Spearman, P ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; PROTEIN PRECURSOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL FRACTIONATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; DETERGENTS; GENE PRODUCTS, GAG; GREEN FLUORESCENT PROTEINS; HIV-1; HUMANS; LUMINESCENT PROTEINS; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; NUCLEOCAPSID; PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; VIRION; VIRUS ASSEMBLY;

EID: 0033862233     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.16.7238-7249.2000     Document Type: Article

References (43)

1. Functional chimeras of the Rous sarcoma virus and human immunodeficiency virus Gag proteins
2. Importance of basic residues in the nucleocapsid sequence for retrovirus Gag assembly and complementation rescue
3. Human immunodeficiency virus type 1 Gag polyprotein multimerization requires the nucleocapsid domain and RNA and is promoted by the capsiddimer interface and the basic region of matrix protein
4. In vitro assembly properties of human immunodeficiency virus type 1 Gag protein lacking the p6 domain
5. Self-assembly in vitro of purified CA-NC proteins from Rous sarcoma virus and human immunodeficiency virus type 1
6. The role of nucleocapsid of HIV-1 in virus assembly
7. Functional domains of the capsid protein of human immunodeficiency virus type 1
8. Myristylation of Rous sarcoma virus Gag protein does not prevent replication in avian cells
9. Specificity and sequence requirements for interactions between various retroviral Gag proteins
10. HIV-1 gag proteins: Diverse functions in the virus life cycle
11. Cryoelectron microscopy reveals ordered domains in the immature HIV-1 particle
12. Recent advances and remaining problems in HIV assembly
13. Identification of retroviral late domains as determinants of particle size
14. Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cells
15. Structure of the amino-terminal core domain of the HIV-1 capsid protein
16. Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release
17. Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: Implications for membrane association and assembly
18. Role of the gag and pol genes of human immunodeficiency virus in the morphogenesis and maturation of retrovirus-like particles expressed by recombinant vaccinia virus: An ultrastructural study
19. Macromolecular interactions in the assembly of HIV and other retroviruses
20. Distinct signals in human immunodeficiency virus type 1 Pr55 necessary for RNA binding and particle formation
21. Formation of virus assembly intermediate complexes in the cytoplasm by wild-type and assembly-defective mutant human immunodeficiency virus type 1 and their association with membranes
22. Identification and characterization of virus assembly intermediate complexes in HIV-1-infected CD4+ T cells
23. Role of the major homology region of human immunodeficiency virus type 1 in virion morphogenesis
24. Comparison of the NMR and X-ray structures of the HIV-1 matrix protein: Evidence for conformational changes during viral assembly
25. Binding of human immunodeficiency virus type 1 Gag to membrane: Role of the matrix amino terminus
26. Opposing effects of human immunodeficiency virus type 1 matrix mutations support a myristyl switch model of Gag membrane targeting
27. Positionally independent and exchangeable late budding functions of the Rous sarcoma virus and human immunodeficiency virus Gag proteins
28. The role of Gag in human immunodeficiency virus type 1 virion morphogenesis and early steps of the viral life cycle
29. The I domain is required for efficient plasma membrane binding of human immunodeficiency virus type 1 Pr55(Gag)
30. Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism
31. Identification of human immunodeficiency virus type 1 Gag protein domains essential to membrane binding and particle assembly
32. Synthesis, assembly, and processing of viral proteins
33. Binding properties of the human immunodeficiency virus type 1 nucleocapsid protein p7 to a model RNA: Elucidation of the structural determinants for function
34. The membrane-binding domain of the Rous sarcoma virus Gag protein
35. Identification of a region in the Pr55gag-polyprotein essential for HIV-1 particle formation
36. Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly
37. Form, function, and use of retroviral gag proteins
38. Creation and expression of myristylated forms of Rous sarcoma virus Gag protein in mammalian cells
39. Molecular recognition in the HIV-1 capsid/cyclophilin A complex
40. Gag-Gag interactions in the C-terminal domain of human immunodeficiency virus type 1 p24 capsid antigen are essential for Gag particle assembly
41. Effects of nucleocapsid mutations on human immunodeficiency virus assembly and RNA encapsidation
42. Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids
43. Differential membrane binding of the human immunodeficiency virus type 1 matrix protein