Exploring computational lead optimisation with affinity constants obtained by surface plasmon resonance for the interaction of PorA epitope peptides with antibody against Neisseria meningitidis

Biochimica et Biophysica Acta - General Subjects

Volumn 1568, Issue 3, 2001, Pages 205-215

  Fischer, Marcel J E ^a   Kuipers, Christiaan ^a   Hofkes, Rolf P ^a   Hofmeyer, Lovina J F ^a   Moret, Ed E ^a   De Mol, Nico J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Binding; De novo design; LUDI; MN12H2; Neisseria meningitidis; SPR

Indexed keywords

BACTERIUM ANTIBODY; EPITOPE; PEPTIDE; PEPTIDE PORA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CYCLIZATION; DRUG DESIGN; ENTROPY; HYDROPHOBICITY; MOLECULAR RECOGNITION; MOLECULAR SIZE; MUTATION; NEISSERIA MENINGITIDIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REACTION OPTIMIZATION; SURFACE PLASMON RESONANCE;

AMINO ACID SEQUENCE; ANTIBODIES, BACTERIAL; CYCLIZATION; DRUG DESIGN; EPITOPES; KINETICS; MODELS, MOLECULAR; NEISSERIA MENINGITIDIS; PEPTIDES; PORINS; SOFTWARE; SOLUTIONS; SURFACE PLASMON RESONANCE;

NEISSERIA; NEISSERIA MENINGITIDIS;

EID: 0035915502     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(01)00215-X     Document Type: Article

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