Failure of co-trimoxazole in Pneumocystis carinii infection and mutations in dihydropteroate synthase gene

Lancet

Volumn 351, Issue 9116, 1998, Pages 1631-1632

  Mei, Qin ^b   Gurunathan, Sanjay ^b   Masur, Henry ^b   Kovacs, Joseph A ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COTRIMOXAZOLE; DIHYDROPTEROATE SYNTHASE; SULFAMETHOXAZOLE; TRIMETHOPRIM;

ADULT; ARTICLE; BACTERIAL GENE; CASE REPORT; CLINICAL FEATURE; DRUG COMBINATION; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PNEUMOCYSTOSIS; PRIORITY JOURNAL;

EID: 0032580729     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)77687-X     Document Type: Article

References (5)

1. 1 USPHS/IDSA Prevention of Opportunistic Infections Working Group. USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: disease-specific recommendations. Clin Infect Dis 1997; 25 (suppl 3): S313-35.
2. 2 Kazanjian P, Locke AB, Hossler PA, et al. Dihydropteroate synthase mutations in Pneumocystis carinii associated with sulfa prophylaxis failures. AIDS (in press).
3. 3 Achari A, Somers DO, Champness JN, Bryant PK, Rosemond J, Stammers DK. Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase. Nat Struct Biol 1997; 4: 490-97.
4. 4 Brooks DR, Wang P, Read M, Watkins WM, Sims PF, Hyde JE. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite. Plasmodium falciparum, with differing resistance to sulfadoxine. Eur J Biochem 1994; 224: 397-405.
5. 5 Moorman A, Von Bargen J, Palella F, Holmberg S. Determinants of "breakthrough" Pneumocystis carinii pneumonia (PCP) in the HIV outpatient study (HOPS) 4th Conf Retro and Opportun Infect 1997; 118 (abstr).