Inhibition of a Gi-activated Potassium Channel (GIRK1/4) by the Gq-coupled m1 Muscarinic Acetylcholine Receptor

Journal of Biological Chemistry

Volumn 276, Issue 8, 2001, Pages 5505-5510

  Hill, Jennifer J ^a   Peralta, Ernest G ^b  

^a PFIZER INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELLS; PROTEINS;

SECOND MESSENGER MOLECULES;

BIOCHEMISTRY;

CALCIMYCIN; CALCIUM IONOPHORE; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; MUSCARINIC M1 RECEPTOR; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN GIRK1; PROTEIN GIRK2; PROTEIN KINASE C; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; G PROTEIN BETA GAMMA; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G-PROTEIN BETA GAMMA; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC RECEPTOR; POTASSIUM CHANNEL; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CHANNEL GATING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; GENE OVEREXPRESSION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; XENOPUS; CALCIUM SIGNALING; DRUG ANTAGONISM; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR CLONING; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; SECOND MESSENGER;

ANIMALIA;

CALCIUM SIGNALING; CLONING, MOLECULAR; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HETEROTRIMERIC GTP-BINDING PROTEINS; PHOSPHORYLATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, MUSCARINIC M1; RECEPTORS, MUSCARINIC; RECOMBINANT PROTEINS; SECOND MESSENGER SYSTEMS;

EID: 0035937126     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008213200     Document Type: Article

References (39)

1. Iismaa, T. P., and Shine, J. (1992) Curr. Opin. Cell. Biol. 4, 195-202
2. Mihara, S., North, R. A., and Surprenant, A. (1987) J. Physiol. (Lond.) 390, 335-355
3. Inoue, M., Nakajima, S., and Nakajima, Y. (1988) J. Physiol. (Lond.) 407, 177-198
4. Stanfield, P. R., Nakajima, Y., and Yamaguchi, K. (1985) Nature 315, 498-501
5. Nakajima, Y., Nakajima, S., and Inoue, M. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 3643-3647
6. Velimirovic, B. M., Koyano, K., Nakajima, S., and Nakajima, Y. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1590-1594
7. Dascal, N. (1997) Cell Signal 9, 551-573
8. Chan, K. W., Langan, M. N., Sui, J. L., Kozak, J. A., Pabon, A., Ladias, J. A., and Logothetis, D. E. (1996) J. Gen. Physiol. 107, 381-397
9. Kofuji, P., Davidson, N., and Lester, H. A. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 6542-6546
10. Silverman, S. K., Lester, H. A., and Dougherty, D. A. (1996) J. Biol. Chem. 271, 30524-30528
11. Krapivinsky, G., Gordon, E. A., Wickman, K., Velimirovic, B., Krapivinsky, L., and Clapham, D. E. (1995) Nature 374, 135-141
12. Soejima, M., and Noma, A. (1984) Pflugers Arch. Eur. J. Physiol. 400, 424-431
13. Logothetis, D. E., Kurachi, Y., Galper, J., Neer, E. J., and Clapham, D. E. (1987) Nature 325, 321-326
14. Wickman, K. D., Iniguez-Lluhi, J. A., Davenport, P. A., Taussig, R., Krapivinsky, G. B., Linder, M. E., Gilman, A. G., and Clapham, D. E. (1994) Nature 368, 255-257
15. Kunkel, M. T., and Peralta, E. G. (1995) Cell 83, 443-449
16. Krapivinsky, G., Krapivinsky, L., Wickman, K., and Clapham, D. E. (1995) J. Biol. Chem. 270, 29059-29062
17. Huang, C. L., Feng, S., and Hilgemann, D. W. (1998) Nature 391, 803-806
18. Sharon, D., Vorobiov, D., and Dascal, N. (1997) J. Gen. Physiol. 109, 477-490
19. Stevens, E. B., Shah, B. S., Pinnock, R. D., and Lee, K. (1999) Mol. Pharmacol. 55, 1020-1027
20. Rogalski, S. L., Cyr, C., and Chavkin, C. (1999) J. Neurochem. 72, 1409-1416
21. Kunkel, M. T., and Peralta, E. G. (1993) EMBO J. 12, 3809-3815
22. Dascal, N., Landau, E. M., and Lass, Y. (1984) J. Physiol. (Lond.) 352, 551-574
23. Kovoor, A., Henry, D. J., and Chavkin, C. (1995) J. Biol. Chem. 270, 589-595
24. Reuveny, E., Slesinger, P. A., Inglese, J., Morales, J. M., Iniguez-Lluhi, J. A., Lefkowitz, R. J., Bourne, H. R., Jan, Y. N., and Jan, L. Y. (1994) Nature 370, 143-146
25. Velimirovic, B. M., Gordon, E. A., Lim, N. F., Navarro, B., and Clapham, D. E. (1996) FEBS Lett. 379, 31-37
26. Peralta, E. G., Ashkenazi, A., Winslow, J. W., Ramachandran, J., and Capon, D. J. (1988) Nature 334, 434-437
27. Ashkenazi, A., Peralta, E. G., Winslow, J. W., Ramachandran, J., and Capon, D. J. (1989) Trends Pharmacol. Sci. 10, (suppl.) 16-22
28. Huang, X. Y., Morielli, A. D., and Peralta, E. G. (1993) Cell 75, 1145-1156
29. Newton, A. C. (1997) Curr. Opin. Cell. Biol. 9, 161-167
30. Hofmann, K., Bucher, P., Falquet, L., and Bairoch, A. (1999) Nueleic Acids Res. 27, 215-219
31. Chan, K. W., Sui, J. L., Vivaudou, M., and Logothetis, D. E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14193-14198
32. Vivaudou, M., Chan, K. W., Sui, J. L., Jan, L. Y., Reuveny, E., and Logothetis, D. E. (1997) J. Biol. Chem. 272, 31553-31560
33. Nishikawa, K., Toker, A., Johannes, F. J., Songyang, Z., and Cantley, L. C. (1997) J. Biol. Chem. 272, 952-960
34. Zhu, G., Qu, Z., Cui, N., and Jiang, C. (1999) J. Biol. Chem. 274, 11643-11646
35. Huang, C. L., Slesinger, P. A., Casey, P. J., Jan, Y. N., and Jan, L. Y. (1995) Neuron 15, 1133-1143
36. Kubo, Y., Reuveny, E., Slesinger, P. A., Jan, Y. N., and Jan, L. Y. (1993) Nature 364, 802-806
37. Dascal, N., Lim, N. F., Schreibmayer, W., Wang, W., Davidson, N., and Lester, H. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6596-6600
38. Nair, L. A., Inglese, J., Stoffel, R., Koch, W. J., Lefkowitz, R. J., Kwatra, M. M., and Grant, A. O. (1995) Circ. Res. 76, 832-838
39. Yamada, M., Ho, Y. K., Lee, R. H., Kontanill, K., Takahashill, K., Katadall, T., and Kurachi, Y. (1994) Biochem. Biophys. Res. Commun. 200, 1484-1490