Receptor binding kinetics of human IL-3 variants with altered proliferative activity

Biochemical and Biophysical Research Communications

Volumn 288, Issue 5, 2001, Pages 1244-1249

  Klein, Barbara K ^a   Shieh, Jeng Jong ^a   Grabbe, Edith ^a   Li, Xiong ^a   Welply, Joseph K ^a   McKearn, John P ^a  

^a PFIZER INC   (United States)

Author keywords

IL 3; Kinetics; Plasmon resonance; Receptor binding

Indexed keywords

AMINO ACID; INTERLEUKIN 3; INTERLEUKIN 3 RECEPTOR; RECEPTOR SUBUNIT; STAT5 PROTEIN;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHEMICAL REACTION KINETICS; DISSOCIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0035900596     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5907     Document Type: Article

References (18)

1. 1H, 13C, and 15N NMR resonance assignments, secondary structure and Backbone topology of a variant of human interleukin-3
2. Saturation mutagenesis of human interleukin-3
3. Potent interleukin-3 receptor agonist with selectivity enhanced hematopoietic activity relative to rhIL-3
4. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for human IL-3 and GM-CSF receptors
5. Functional reconstitution of the human interleukin-3 receptor
6. JAKS and STATS: Biological implications
7. Suppression of interleukin-3 induced gene expression by a C-terminal truncated Stat5: Role of Stat 5 in proliferation
8. The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling
9. A human interleukin 3 analog with increased biological and binding activities
10. A discontinuous eight-amino acid epitope in human interleukin-3 binds the α-chain of its receptor
11. Two contiguous residues in human interleukin-3, Asp21 and Glu22 selectively interact with the alpha and beta-chains of its receptor and participate in function
12. Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors
13. Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity
14. Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor a chain recognition
15. A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor a chain
16. The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: Further evidence for intervening sequence-mediated domain transfer