Delineating functionally important regions and residues in the cathepsin B propeptide for inhibitory activity

FEBS Letters

Volumn 393, Issue 1, 1996, Pages 24-26

  Chen, Yanmin ^a   Plouffe, Céline ^a   Ménard, Robert ^a   Storer, Andrew C ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Cysteine protease; Inhibition; Propeptide

Indexed keywords

CYSTEINE PROTEINASE;

AMINO ACID COMPOSITION; ARTICLE; DELETION MUTANT; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

EID: 0030577020     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(96)00847-2     Document Type: Article

References (20)

1. [1] Knop, M., Schiffer, H.H., Rupp, S. and Wolf, D.H. (1993) Cur. Opin. Cell Biol. 5, 990-996.
2. [2] Takahashi, H., Cease, K.B. and Berzofsky, J.A. (1989) J. Immunol. 142, 2221-2229.
3. [3] Vaes, G. (1988) Clin. Orthop. 231, 239-271.
4. [4] Trabandt A., Gay, R.E., Fassbender, H.G. and Gay, S. (1991) Arthr. Rheum. 34, 1444-1451.
5. [5] Esser, R.E., Angelo, R.A., Murphey, M.D., Watts, L.M., Thornburg, L.P., Palmer, J.T., Talhouk, J.W. and Smith, R.E. (1994) Arthr. Rheum. 37, 236-247.
6. [6] Sheahan, K., Shuja, S. and Murnane, M.J. (1989) Cancer Res. 49, 3809-3814.
7. [7] Duffy, M.J. (1992) Clin. Exp. Metastasis 10, 145-155.
8. [8] Katunuma, N. and Kominami, E. (1987) Rev. Physiol. Biochem. Pharmacol. 108, 1-20.
9. [9] Brocklehurst, K., Willenbrock, F. and Salih, E. (1987) in: Hydrolytic Enzymes (A. Neuberger and K. Brocklehurst, Eds.), pp. 39-158, Elsevier, Amsterdam.
10. [10] Murata, M., Miyashita, S., Yokoo, C., Tamai, M., Hanada, K., Hatayama, K., Towatari, T., Nikawa, T. and Katunuma, N. (1991) FEBS Lett. 280, 307-310.
11. [11] Buttle, D.J., Murata, M., Knight, C.G. and Barrett, A.J. (1992) Arch. Biochem. Biophys. 299, 377-380.
12. [12] Gour-Salin, B.J., Lachance, P., Plouffe, C., Storer, A.C. and Ménard, R. (1993) J. Med. Chem. 36, 720-725.
13. [13] Fox, T., de Miguel, E., Mort, J.S. and Storer, A.C. (1992) Biochemistry 31, 12571-12576.
14. [14] Carmona, E., Dufour, É., Plouffe, C., Takebe, S., Mason, P., Mort, J.S. and Ménard. R. (1996) Biochemistry 35, 8149-8157.
15. [15] Rowan, A.D., Mason, P., Mach, L. and Mort, J.S. (1992) J. Biol. Chem. 267, 15993-15999.
16. [16] Ménard, R., Khouri, H.E., Plouffe, C., Dupras, R., Rippoll, D., Vernet, T., Tessier, D.C., Laliberté, F., Thomas, D.Y. and Storer, A.C. (1990) Biochemistry 29, 6706-6713.
17. [17] Dixon, M. (1953) Biochem. J. 55, 170-171
18. [18] Cygler, M., Sivaraman, J., Grochulski, P., Coulombe, R., Storer, A.C. and Mort, J.S. (1996) Structure 4, 405-416.
19. [19] Turk, D., Podobnik, M., Kuhelj, R., Dolinar, M., Turk, V. (1996) FEBS Lett. 384, 211-214.
20. [20] Chan, S.J., San Segundo, B., McCormick, M.B. and Steiner, D.F. (1986) Proc. Natl. Acad. Sci. USA 83, 7721-7725.