Glycosylation alters steady-state inactivation of sodium channel NAv1.9/NaN in dorsal root ganglion neurons and is developmentally regulated

Journal of Neuroscience

Volumn 21, Issue 24, 2001, Pages 9629-9637

  Tyrrell, Lynda ^a,b   Renganathan, Muthukrishnan ^a,b   Dib Hajj, Sulayman D ^a,b   Waxman, Stephen G ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Desialidation; Ion channel; Persistent Na current; Spinal sensory neurons; Tetrodotoxin resistant; Voltage clamp

Indexed keywords

SODIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; GLYCOSYLATION; GROWTH REGULATION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM CURRENT; SPINAL GANGLION; STEADY STATE; VOLTAGE CLAMP;

EID: 0035894883     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-24-09629.2001     Document Type: Article

References (39)

1. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
2. Purification from rat sarcolemma of the saxitoxin-binding component of the excitable membrane sodium channel
3. Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development
4. Cloning of a sodium channel alpha subunit from rabbit Schwann cells
5. Contribution of sialic acid to the voltage dependence of sodium channel gating. A possible electrostatic mechanism
6. Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs
7. From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
8. Voltage-dependent sodium channels
9. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons
10. Glial-derived neurotrophic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons
11. Nav1.3 sodium channels: Rapid repriming and slow closed-state inactivation display quantitative differences following expression in a mammalian cell line and in spinal sensory neurons
12. Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy
13. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
14. Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons
15. Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN
16. Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and HNE (PN1) - Different expression patterns in developing rat nervous system
17. Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section
18. Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
19. The action of calcium on the electrical properties of squid axon
20. Resurgence of sodium channel research
21. Nomenclature of voltage-gated sodium channels
22. Mutually exclusive exon splicing of type III brain sodium channel alpha subunit RNA generates developmentally regulated isoforms in rat brain
23. Role of resistant tetrodotoxin-resistant (TTX-R) sodium currents in modulating dorsal root ganglia (DRG) excitability: A computer simulation and patchclamp study
24. Voltage-dependent sodium and calcium currents in acutely isolated adult rat trigeminal root ganglion neurons
25. The sodium channel from rat brain. Separation and characterization of subunits
26. Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein from Electrophorus electricus: Isolation and partial chemical and physical characterization
27. Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells
28. Neuraminidase treatment modifies the function of electroplax sodium channels in planar lipid bilayers
29. Nitric oxide is an autocrine regulator of Na(+) currents in axotomized C-type DRG neurons
30. Alpha-SNS produces the slow TTX-resistant sodium current in large cutaneous afferent DRG neurons
31. The voltage-sensitive sodium channel from rabbit skeletal muscle. Chemical characterization of subunits
32. Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs
33. Developmental and regional expression of sodium channel isoform NaCh6 in the rat central nervous system
34. Biosynthesis and processing of the alpha subunit of the voltage-sensitive sodium channel in rat brain neurons
35. Palmitylation, sulfation, and glycosylation of the alpha subunit of the sodium channel. Role of post-translational modifications in channel assembly
36. + channels in mammalian brain and in transfected cells
37. Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy
38. Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure
39. Glycosylation influences voltage-dependent gating of cardiac and skeletal muscle sodium channels