In vivo cellular uptake of glutamate is impaired in the rat hippocampus during and after transient cerebral ischemia: A microdialysis extraction study

Journal of Neuroscience Research

Volumn 66, Issue 6, 2001, Pages 1118-1126

  Bruhn, Torben ^a   Christensen, Thomas ^a   Diemer, Nils Henrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Glutamate; Ischemia; Microdialysis; Rat; Uptake

Indexed keywords

ASPARTIC ACID; GLUTAMIC ACID; MANNITOL;

AMINO ACID ANALYSIS; AMINO ACID TRANSPORT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL FRACTIONATION; CELL LOSS; CONTROLLED STUDY; DIALYSATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; HISTOPATHOLOGY; MICRODIALYSIS; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SCINTILLATION;

ANIMALS; ASPARTIC ACID; BRAIN ISCHEMIA; CARRIER PROTEINS; ENZYME INHIBITORS; EXTRACELLULAR SPACE; GLUTAMIC ACID; HIPPOCAMPUS; MALE; MICRODIALYSIS; NERVE DEGENERATION; PRESYNAPTIC TERMINALS; RATS; RATS, WISTAR; SYNAPTIC TRANSMISSION; TRITIUM;

EID: 0035892684     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10011     Document Type: Article

References (38)

1. Changes in extracellular amino acids and spontaneous neuronal activity during ischemia and extended reflow in the CA1 of the rat hippocampus
2. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
3. Determination of brain interstitial concentrations by microdialysis
4. Microdialysis - Theory and application
5. Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus
6. Microdialysis as a tool for in vivo investigation of glutamate transport capacity in rat brain
7. Evidence for increased cellular uptake of glutamate and aspartate in the rat hippocampus during kainic acid seizures. A microdialysis study using the "indicator diffusion" method
8. Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: A microdialysis study of freely moving rats
9. Ischemia induced changes in expression of the astrocyte glutamate transporter GLT1 in hippocampus of the rat
10. Phenylsuccinate reduces KCl-induced release of GABA. Evidence for the participation of the ketodicarboxylate carrier in the biosynthesis of transmitter-GABA
11. The permeability of capillaries in various organs as determined by use of the "indicator diffusion" method
12. The high affinity uptake system for excitatory amino acids in the brain
13. Protection against ischemic hippocampal CA1 damage in the rat with a new non-NMDA antagonist, NBQX
14. Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST
15. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel
16. Transient neurophysiological changes in CA3 neurons and dentate granule cells after severe forebrain ischemia in vivo
17. Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia
18. Regional differentiation downregulates subtypes of glutamate transporter proteins
19. The extracellular potassium concentration in brain cortex after ischemia in hypo- and hyper-glycemic rats
20. Electrophysiological changes of CA3 neurons and dentate granule cells following transient forebrain ischemia
21. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus
22. Primary structure and functional characterization of a high-affinity glutamate transporter
23. The elusive transporters with a high affinity for glutamate
24. Delayed neuronal death in the rat hippocampus following transient forebrain ischemia
25. Down-regulation of glial glutamate transporters after glutamatergic denervation in the rat brain
26. Changes in energy state and acid-base parameters of the rat brain during complete compression ischemia
27. Substrate-induced upregulation of Na(+)-dependent glutamate transport activity
28. Cloning and expression of a rat brain L-glutamate transporter
29. A new model of bilateral hemispheric ischemia in the unanesthetized rat
30. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
31. +-dependent glutamate transporters by cyclic AMP analogs and neurons
32. Transport and metabolism of glutamate and GABA in neurons and glial cells
33. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A neuroprotectant for cerebral ischemia
34. Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain
35. Glutamine transport in cerebellar granule cells in culture
36. Neuronal regulation of glutamate transporter subtype expression in astrocytes
37. Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampus