The human GABAB1b and GABAB2 heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen

British Journal of Pharmacology

Volumn 131, Issue 6, 2000, Pages 1050-1054

  Wood, M D ^a   Murkitt, K L ^a   Rice, S Q ^a   Testa, T ^a   Punia, P K ^a   Stammers, M ^a   Jenkins, O ^a   Elshourbagy, N A ^a   Shabon, U ^a   Taylor, S J ^a   Gager, T L ^a   Minton, J ^a   Hirst, W D ^a   Price, G W ^a   Pangalos, M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Calcium; FLIPR; G(qi5); GABA; Phaclofen; Receptors; Saclofen; aminobutyric acid

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 5,5 DIMETHYL 2 MORPHOLINEACETIC ACID; BACLOFEN; CALCIUM ION; CGP 54626; CGP 54626A; CHIMERIC PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PHACLOFEN; RADIOLIGAND; RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; SACLOFEN; SCG 50911; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CHO CELL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FLUOROMETRY; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR SENSITIVITY;

ANIMALS; BACLOFEN; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA AGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; RECEPTORS, GABA; RECEPTORS, GABA-B;

EID: 0033712421     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703682     Document Type: Article

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