Inhibition of angiogenesis and induction of apoptosis are involved in E1A-mediated bystander effect and tumor suppression

Cancer Research

Volumn 60, Issue 12, 2000, Pages 3123-3126

  Shao, Ruping ^a   Xia, Weiya ^a   Hung, Mien Chie ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS 5; ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL;

ADENOVIRUS E1A PROTEINS; ANIMALS; APOPTOSIS; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; THYMIDINE; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034045709     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Culver, K. W., Ram, Z., Wallbridge, S., Ishii, H., Oldfield, E. H., and Blaese, R. M. In vivo gene transfer with retroviral vector-producer cells for treatment of exprimental brain tumors. Science (Washington DC), 256: 1550-1552, 1992.
2. Mesnil, M., Piccoli, C., Tiraby, G., Willecke, K., and Yamasaki, H. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc. Natl. Acad. Sci. USA, 93: 1831-1835, 1996.
3. Dong, Z., Greene, G., Pettaway, C., Dinney, C. P. N., Eue, I., Lu, W., Bucana, C. D., Balbay, M. D., Bielenberg, D., and Fidler, I. J. Suppression of angiogenesis, tumor-igenicity, and metastasis by human prostate cancer cells engineered to produce interferon-β. Cancer Res., 59: 872-879, 1999.
4. Wei, M. X., Tamiya, T., Hurford, R. K., Jr., Boviatsis, E. J., Tepper, R. I., and Chiocca, E. A. Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer. Hum. Gene Ther., 6: 437-443, 1995.
5. Nishizaki, M., Fujiwara, T., Tanida, T., Hizuta, A., Nishimori, H., Tokino, T., Nakamura, Y., Bouvet, M., Roth, J. A., and Tanaka, N. Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. Clin. Cancer Res., 5: 1015-1023, 1999.
6. Weidner, N., Semple, J. P., Welch, W. R., and Folkman, J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N. Engl. J. Med., 324: 1-8, 1991.
7. Bergers, G., Javaherian, K., Lo, K. M., Folkman, J., and Hanahan, D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science (Washington DC), 284: 808-812, 1999.
8. Yu, D., and Hung, M. C. The erbB2 gene as a cancer therapeutic target and the tumor-and metastasis-suppressing function of E1A. Cancer Metastasis Rev., 17: 195-202, 1998.
9. Mymryk, J. S. Tumour suppressive properties of the adenovirus 5 E1A oncogene. Oncogene, 13: 1581-1589, 1996.
10. Chang, J. Y., Xia, W., Shao, R., Sorgi, F., Hortobagyi, G. N., Huang, L., and Hung, M. C. The tumor suppression activity of E1A in HER-2/neu-overexpressing breast cancer. Oncogene, 14: 561-568, 1997.
11. Chang, J. Y., Xia, W., Shao, R., and Hung, M. C. Inhibition of intratracheal lung cancer development by systemic delivery of E1A. Oncogene, 13: 1405-1412, 1996.
12. Schaeper, U., Boyd, J. M., Verma, S., Uhlmann, E., Subramanian. T., and Chinnadurai, G. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl. Acad. Sci. USA, 92: 10467-10471, 1995.
13. Frisch, S. M., and Dolter, K. E. Adenovirus E1α-mediated tumor suppression by a c-erbB-2/neu-independent mechanism. Cancer Res., 55: 5551-5555, 1995.
14. Lee, W. P., Liao, Y., Robinson, D., Kung, H. J., Liu, E. T., and Hung, M. C. Axl-Gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity. Mol. Cell. Biol., 19: 8075-8082, 1999.
15. Shao, R., Hu, M. C. T., Zhou, B. P., Lin, S. Y., Chiao, P. J., von Lindern, R. H., Spohn, B., and Hung, M. C. E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IKB kinases and nuclear factor KB activities. J. Biol. Chem., 274, 21495-21498, 1999.
16. Shao, R., Karunagaran, D., Zhou, B. P., Li, K., Lo., S. S., Deng, J., Chiao, P., and Hung, M. C. Inhibition of nuclear factor KB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis. J. Biol. Chem., 272: 32739-32742. 1997.
17. Fearnhead, H. O., McCurrach, M. E., O'Neill, J., Zhang, K., Lowe, S. W., and Lazebnik, Y. A. Oncogene-dependent apoptosis in extracts from drug-resistant cells. Genes Dev., 11: 1266-1276, 1997.
18. de Stanchina, E., McCurrach, M. E., Zindy, F., Shieh, S. Y., Ferbeyre, G., Samuelson, A. V., Prives, C., Roussel, M. F., Sherr, C. J., and Lowe, S. W. E1A signaling to p53 involves the p19ARF tumor suppressor. Genes Dev., 12: 2434-2442, 1998.
19. Chiou, S. K., and White, E. p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis. J. Virol., 71: 3515-3525, 1997.
20. Bruckheimer, E. M., Gjertsen, B. T., and McDonnell, T. J. Implications of cell death regulation in the pathogenesis and treatment of prostate cancer. Semin. Oncol., 26: 382-398, 1999.