Bioactivation and toxicity in vitro of HCFC-123 and HCFC-141b: Role of cytochrome P450

Toxicology Letters

Volumn 124, Issue 1-3, 2001, Pages 139-152

  Zanovello, Alberta ^a   Ferrara, Roberta ^a   Tolando, Roberto ^a   Bortolato, Silvia ^a   White, Ian N H ^b   Manno, Maurizio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

1,1 Dichloro 1 fluoroethane; 1,1 Dichloro 2,2,2 trifluoroethane; Bioactivation; Cytochrome P450; Hepatocytes; Liver microsomes

Indexed keywords

1,1 DICHLORO 1 FLUOROETHANE; 1,1 DICHLORO 2,2,2 TRIFLUOROETHANE; 4 METHYLPYRAZOLE; ALKADIENE; CHLOROFLUOROCARBON; CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 2E1; FREE RADICAL; GLUTATHIONE; LACTATE DEHYDROGENASE; LIPID PEROXIDE; PHENOBARBITAL; PYRIDINE; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; LIPID PEROXIDATION; LIVER CELL; LIVER MICROSOME; NONHUMAN; OZONE LAYER; PRIORITY JOURNAL; RAT;

ANIMALS; BIOTRANSFORMATION; CHLOROFLUOROCARBONS; CYTOCHROME P-450 ENZYME SYSTEM; EXCITATORY AMINO ACID ANTAGONISTS; FREE RADICALS; GLUTATHIONE; HEPATOCYTES; L-LACTATE DEHYDROGENASE; MALE; MICROSOMES, LIVER; PHENOBARBITAL; PYRIDINES; RATS; RATS, WISTAR;

EID: 0035887107     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00385-X     Document Type: Article

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