Exposure to 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) and acute liver dysfunction: A causal inference

Journal of Occupational Health

Volumn 40, Issue 4, 1998, Pages 334-338

  Takebayashi, Toru ^a   Kabe, Isamu ^a   Endo, Yu'ichi ^a   Tanaka, Shigeru ^b   Miyauchi, Hiroyuki ^c   Nozi, Kazuko ^a   Imamiya, Shun Ichiro ^c   Takahashi, Ken ^a   Omae, Kazuyuki ^a  

^a KEIO UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c Association of Industrial Health   (Japan)

Author keywords

2,2 Dichloro 1,1,1 trifluoroethane; Chlorofluorocarbon substitute; Exposure effect relationship; Exposure response relationship; Liver toxicity

Indexed keywords

1,1 DICHLORO 2,2,2 TRIFLUOROETHANE; CHLOROFLUOROCARBON;

ACUTE TOXICITY; ARTICLE; CLINICAL ARTICLE; DISEASE SEVERITY; FEMALE; HUMAN; INDUSTRIAL WORKER; LIVER FUNCTION TEST; LIVER TOXICITY; MALE; OCCUPATIONAL EXPOSURE; SYMPTOMATOLOGY;

EID: 0032412282     PISSN: 13419145     EISSN: None     Source Type: Journal    
DOI: 10.1539/joh.40.334     Document Type: Article

References (14)

1. Rusch GM, Trochimowicz HJ, Malley LJ, et al. Subchronic inhalation toxicity studies with hydrochlorofluorocarbon 123 (HCFC-123). Fundam Appl Toxicol 1994; 23: 169-178.
2. Malley LA, Carakostas M, Hansen JF, Rusch GM, Kelly DP, Trochimowicz HJ. Two-year inhalation toxicity study in rats with hydrochlorofluorocarbon 123. Fundam Appl Toxicol 1995; 25: 101-114.
3. Malinverno G, Rusch GM, Millischer RJ, Hughes EW, Schroeder RE, Coombs DW. Inhalation teratology and reproduction studies with 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123). Fundam Appl Toxicol 1996;34:276-287.
4. Hoet P, Graf ML, Bourdi M, et al. Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons. Lancet 1997; 350: 556-559.
5. Takebayashi T, Kabe I, Endo Y, et al. Acute liver dysfunction among workers exposed to 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123): a case report. J Occup Health 1998; 40: 169-170.
6. Urban G, Dekant W. Metabolism of 1,1-dichloro-2,2,2-trifluoroethane in rats. Xenobiotica 1994; 24: 881-92.
7. Tanaka S, Kabe I, Takebayashi T, et al. Environmental and Biological Monitoring of 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123). J Occup Health 1998; 40: 348-349.
8. Inoue T. A table of subjective symptom questionnaires for solvent workers. In: Japan Industrial Safety and Health Association, editor. Health management of solvent workers. Tokyo: Japan Industrial Safety and Health Association, 1983: 66-67.
9. Takebayashi T, Omae K, Ishizuka C, et al. Cross sectional observation of the effects of carbon disulphide on in the nervous system, endocrine system, and subjective symptoms in rayon manufacturing workers. Occup Environ Med 1998; 55: 473-479.
10. Marit GB, Dodd DE, George ME, Vinegar A. Hepatotoxicity in guinea pigs following acute inhalation exposure to 1,1-dichloro-2,2,2-trifluoroethane. Toxicol Pathol 1994; 22: 404-414.
11. Urban G, Speerschneider P, Dekant W. Metabolism of the chlorofluorocarbon substitute 1,1-dichloro-2,2,2-trifluoroethane by rat and human liver microsomes: the role of cytochrome P450 2E1. Chem Res Toxicol 1994; 7: 170-176.
12. Lind RC, Gandolfi AJ, Hall PD. Biotransformation and hepatotoxicity of HCFC-123 in the guinea pig: potentiation of hepatic injury by prior glutathione depletion. Toxicol Appl Pharmacol 1995; 134: 175-181.
13. Lind RC, Gandolfi AJ, Brown BR, Jr., Hall PM. Halothane hepatotoxicity in guinea pigs. Anesth Analg 1987; 66: 222-228.
14. Clarke JB, R.C. L, Gandolfi AJ. Mechanisms of anesthetic hepatotoxicity. Advances in Anesthesia 1993; 10: 219-246.