Bioactivation to free radicals and cytotoxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b)

Xenobiotica

Volumn 31, Issue 2, 2001, Pages 99-112

  Zanovello, A ^a   Tolando, R ^a   Ferrara, R ^a   Bortolato, S ^a   Manno, M ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DICHLORO 1 FLUOROETHANE; 4 METHYLPYRAZOLE; ALKADIENE; ASCORBIC ACID; CHLOROFLUOROCARBON; CHLOROFLUOROHYDROCARBON; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; FREE RADICAL; GLUTATHIONE; LACTATE DEHYDROGENASE; MALEIC ACID DIETHYL ESTER; METYRAPONE; N TERT BUTYL ALPHA PHENYLNITRONE; PHORONE; PYRIDINE; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DOSE RESPONSE; ELECTRON SPIN RESONANCE; ENZYME RELEASE; LIVER CELL; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHLOROFLUOROCARBONS; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; FREE RADICALS; GLUTATHIONE; HEPATOCYTES; ISOENZYMES; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MALE; METYRAPONE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PYRAZOLES; PYRIDINES; RATS; RATS, WISTAR; TROLEANDOMYCIN;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0034991344     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250010031656     Document Type: Article

References (33)

1. Use of isolated hepatocytes for the detection of free radical intermediates of halogenated hydrocarbons
2. Acute and subchronic toxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b)
3. Anaerobic technique for spectrometric studies of oxidative enzymes with low oxidation-reduction potentials
4. Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo
5. Toxicology of chlorofluorocarbon replacements
6. Cytochrome P450 inactivation during reductive metabolism of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) by phenobarbital- and pyridine-induced rat liver microsomes
7. Reductive bioactivation of HCFC-141b to free radical intermediates by rat liver microsomal cytochrome P-450
8. Glutathione and glutathione disulfide
9. Tissue acylation by the chlorofluorocarbon substitute 2,2-dichloro-1,1,1-trifluoroethane
10. Lipid peroxidation: A radical chain reaction
11. The kidney as a novel target tissue for protein adduct formation associated metabolism of halotane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane
12. Mechanistic insights aid the search for CFC substitutes: Risk assessment of HCFC-123 as an example
13. A simple procedure for the isolation of rat liver microsomes
14. Biochemical mechanisms of chemical-induced lipid peroxidation
15. Concentration-dependent inhibition of halotane biotransformation in the guinea pig
16. Biotransformation and hepatotoxicity of HCFC-123 in the guinea pig: Potentiation of hepatic injury by prior glutathione depletion
17. Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluororthane (HCFC-141b)
18. Cutaneous malignant melanoma and ultraviolet radiation. A review
19. The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane
20. The mechanism of the suicidal, reductive inactivation of microsomal cytochrome P-450 by carbon tetrachloride
21. Cytotoxicity of HCFC-123 in isolated rat hepatocytes
22. Dose- and time-dependent cytotoxicity of HCFC-123 and HCFC-141 b on isolated rat hepatocytes under aerobic and hypoxic conditions
23. Stratospheric sink for chlorofluoromethanes: Chlorine atom-catalysed destruction of ozone
24. Mechanism of chloroform and carbon tetrachloride toxicity in primary cultured mouse hepatocytes
25. Effect of ultraviolet radiation on cataract formation
26. Reductive activation of 1,1,-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital-and pyridine-induced rat liver microsomal cytochrome P450
27. The metabolism of halothane by hepatocytes: A comparison between free radical spin-trapping and lipid peroxidation in relation to cell damage
28. Metabolism of 1,1-dichloro-1-fluoroethane (HCFC-141b) in human volunteers
29. Evaluation of lipid peroxidation in lipids and biological membranes
30. Rat hepatocyte primary cell cultures
31. Effect of P450 inhibitors on the bioactivation and cytotoxicity of HCFC-123 and HCFC-141b in isolated rat hepatocytes