Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells

Biochemical Pharmacology

Volumn 62, Issue 4, 2001, Pages 431-438

  Porter, Richard H P ^a   Malcolm, Craig S ^a   Allen, Nicola H ^a   Lamb, Helen ^a   Revell, Dean F ^a   Sheardown, Malcolm J ^a  

^a Vernalis PLC   (United Kingdom)

Author keywords

5 HT2; Desensitisation; Receptor; RNA editing; Serotonin

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; ADENOSINE TRIPHOSPHATE; ISOPROTEIN; PARTIAL AGONIST; PURINE RECEPTOR; RECOMBINANT RECEPTOR; SEROTONIN; SEROTONIN 2 RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN AGONIST;

ANIMAL CELL; ARTICLE; CELL LINE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG EXPOSURE; DRUG POTENCY; DRUG REEXPOSURE; DRUG RESPONSE; HUMAN; HUMAN CELL; INCUBATION TIME; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; RNA EDITING; SIGNAL TRANSDUCTION; TIME;

ANIMALS; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PIPERAZINES; RECEPTORS, PURINERGIC; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; SEROTONIN; SEROTONIN AGONISTS; TIME FACTORS; TRANSFECTION;

EID: 0035882766     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00677-3     Document Type: Article

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