Hoxa3 and Pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis

Developmental Biology

Volumn 236, Issue 2, 2001, Pages 316-329

  Su, Dong ming ^a   Ellis, Steve ^a   Napier, Audrey ^a   Lee, Kristin ^a   Manley, Nancy R ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Apoptosis; Endoderm; Gcm2; Hox; Organogenesis; Parathyroid; Pax; Pharyngeal pouch; Proliferation; Thymus

Indexed keywords

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENDODERM; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; HYPOPLASIA; MUTANT; NONHUMAN; ORGANOGENESIS; PARATHYROID GLAND; PRIORITY JOURNAL; THYMUS;

EID: 0035881214     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2001.0342     Document Type: Article

References (42)

1. The gcm-motif: A novel DNA-binding motif conserved in Drosophila and mammals
2. Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse
3. The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors
4. p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells
5. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain
6. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5
7. Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis
8. Development of thymus, parathyroids, and ultimobranchial bodies in NMRI and Nude mice
9. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11
10. Undulated phenotypes suggest a role of Pax-1 for the development of vertebral and extravertebral structures
11. Vertebrate Hox genes and proliferation: An alternative pathway to homeosis?
12. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
13. Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth
14. Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch
15. Genetic ablation of parathyroid glands reveals another source of parathyroid hormone
16. Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments
17. Unified nomenclature for the winged helix/forkhead transcription factors
18. Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing
19. A novel cell surface antigen, immature thymocyte antigen-1, is involved in the differentiation of murine thymocytes
20. Fetal parathyroids are not required to maintain placental calcium transfer
21. Hox genes in vertebrate development
22. Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation
23. The role of hoxa-3 in mouse thymus and thyroid development
24. Hox group 3 paralogs regulate the development and migration of the thymus, thyroid and parathyroid glands
25. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
26. The ultimobranchial origin of calcitonin
27. Two genetically separable steps in the differentiation of thymic epithelium
28. New member of the winged-helix protein family disrupted in mouse and rat nude mutations
29. Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1
30. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
31. Pax1 and Pax9 synergistically regulate vertebral column development
32. Deoxyguanosine-induced survival of class II-expressing fetal mouse thymic allografts is associated with the depletion of donor lymphoid and dendritic cells
33. Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
34. A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis
35. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
36. Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation
37. Genetic dissection of thymus development
38. − thymocytes
39. Hoxa3 and Pax1 transcription factors regulate the ability of fetal thymic epithelial cells to promote thymocyte development
40. Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation
41. Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere
42. Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency