Biochemical characterization of the small isoform of Drosophila melanogaster RECQ5 helicase

Nucleic Acids Research

Volumn 29, Issue 14, 2001, Pages 2986-2993

  Özsoy, A Zeynep ^a   Sekelsky, Jeff J ^b   Matson, Steven W ^b  

^a Curriculum in Genetics and Molecular Biology   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE KINASE; DOUBLE STRANDED DNA; HELICASE; ISOPROTEIN; NUCLEOTIDE; RNA; SINGLE STRANDED DNA;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DNA DENATURATION; DROSOPHILA; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ESCHERICHIA COLI; GENETIC CODE; GENETIC TRANSCRIPTION; HYDROLYSIS; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ANIMALIA; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; MELANOGASTER;

EID: 0035878693     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.14.2986     Document Type: Article

References (34)

1. RecQ family helicase: Roles in cancer and aging
2. The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains
3. Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs
4. Werner syndrome protein I. DNA helicase and DNA exonuclease reside on the same polypeptide
5. Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A
6. The premature ageing syndrome protein, WRN, is a 3′ to 5′ exonuclease
7. Werner syndrome protein III. Characterization of the integral 3′ to 5′ exonuclease
8. Werner syndrome helicase contains a 5′ to 3′ exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding
9. Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
10. Sgs1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation
11. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
12. Mapping the DNA topoisomerase III binding domain of the Sgs1 DNA helicase
13. Interaction between yeast Sgs1 helicase and DNA topoisomerase III
14. rqh1 +, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
15. Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human Bloom syndrome gene
16. Cloning of the two new human helicase genes of the RecQ family: Biological significance of multiple species in higher eukaryotes
17. Rothmund Thomson syndrome due to RECQ4 helicase mutations: Report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome
18. DNA helicase, genomic instability, and human genetic disease
19. Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing
20. Human RecQ5β, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3α and 3β
21. A preformed, topologically stable replication fork
22. Escherichia coli helicase II (uvrD gene product) translocates unidirectionally in a 3′ to 5′ direction
23. DNA-dependent nucleoside 5′-triphosphatase activity of the Gene4 protein of bacteriophage T7
24. Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
25. Cloning of two isoforms of mouse DNA helicase Q1/RecQL cDNA; α form is expressed ubiquitously and β form specifically in the testis
26. Identification of Drosophila melanogaster RECQE as a member of a new family of RecQ homologues that is preferentially expressed in early embryos
27. DNA helicases: Enzymes with essential roles in all aspects of DNA metabolism
28. Escherichia coli DNA helicase I catalyzes a unidirectional and highly processive unwinding reaction
29. RecQ DNA helicase of Escherichia coli. Characterization of the helix-unwinding activity with emphasis on the effect of single-stranded DNA-binding protein
30. Helicases: Amino acid sequence comparisons and structure-function relationships
31. Biochemical characterization of the DNA helicase activity of the Escherichia coli RecQ helicase
32. Functional and physical interaction between WRN helicase and human replication protein A
33. Oligomeric ring structure of the Bloom's syndrome helicase
34. Differential ATP requirements distinguish the DNA translocation and DNA unwinding activities of the Escherichia coli PRI A protein