Differential survival of transferred CD8 T cells and host reconstitution depending on TCR avidity for host-expressed alloantigen

Journal of Immunology

Volumn 166, Issue 12, 2001, Pages 7200-7207

  Auphan Anezin, N ^a   Schmitt Verhulst, A M ^a  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PADGEM PROTEIN; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR;

ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CELL FUNCTION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; CYTOTOXICITY; DOWN REGULATION; GRAFT VERSUS HOST REACTION; IMMUNOSTIMULATION; IMMUNOTHERAPY; LYMPHOPOIESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

EID: 0035877188     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.12.7200     Document Type: Article

References (35)

1. + T cells
2. + T cells by a self-derived peptide
3. Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide
4. Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis
5. Differential requirements for NF-κB and AP-1 transactivation in response to minimal TCR engagement by a partial agonist in naive CD8 T cells
6. Winning the battle of graft versus host
7. Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: Reagents for tumor immunotherapy
8. Identification of endogenous peptides recognized by in vivo or in vitro generated alloreactive CTL: Distinct characteristics correlated with CD8-dependence
9. The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the TCR and influences negative selection in TCR-transgenic mice
10. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
11. Role of CD3δ in surface expression of the T cell antigen receptor/CD3 complex and in activation for killing analyzed with CD3δ negative cytolytic T lymphocyte variant
12. Lymphoid cell surface interaction structures detected using cytolysis-inhibiting monoclonal antibodies
13. Determination of lymphocyte division by flow cytometry
14. Consequences of intrathymic TCR engagement by partial agonist on selection events and peripheral T cell activation program
15. The Bcl-2 family: Arbiters of cell survival
16. L or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after viral infection
17. + T cells in lymphopenic hosts
18. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
19. Differential requirements for survival and proliferation of CD8 naive or memory T cells
20. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists
21. TCR transgenic mice in which usage of transgenic α- and β-chains is highly dependent on the level of selecting ligand
22. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment
23. The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice
24. Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease
25. A major role for the Fas pathway in acute graft-versus-host disease
26. Differential effects of anti-Fas ligand and anti-tumor necrosis factor α antibodies on acute graft-versus-host disease pathologies
27. Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo
28. Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo
29. Differentiation of naive CTL to effector and memory CTL: Correlation of effector function with phenotype and cell division
30. Massive activation-induced cell death of alloreactive T cells with apoptosis of bystander postthymic T cells prevents immune reconstitution in mice with graft-versus-host disease
31. Prevention of marrow graft rejection without induction of graft-versus-host disease by a cytotoxic T-cell clone that recognizes recipient alloantigens
32. Functional responses and apoptosis of CD25(IL-2Rα-deficient T cells expressing a transgenic antigen receptor
33. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
34. + T cell survival but not for antigen proliferation
35. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo