Human T cells infiltrate and injure pig coronary artery grafts with activated but not quiescent endothelium in immunodeficient mouse hosts

Transplantation

Volumn 71, Issue 11, 2001, Pages 1622-1630

  Tereb, Denis A ^a   Kirkiles Smith, Nancy C ^a   Kim, Richard W ^a   Wang, Yinong ^a   Rudic, R Daniel ^a   Schechner, Jeffrey S ^a   Lorber, Marc I ^a   Bothwell, Alfred L M ^a   Pober, Jordan S ^a   Tellides, George ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL INJURY; CELL INFILTRATION; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; ENDOTHELIUM CELL; HISTOLOGY; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LEUKOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE;

EID: 0035875839     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200106150-00023     Document Type: Article

References (42)

1. Xenogeneic transplantation
2. Effect of transgenic expression of human decay-accelerating factor on the inhibition of hyperacute rejection of pig organs
3. The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants
4. Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis
5. Accommodation of vascularized xenografts: Expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment
6. Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment
7. Effector mechanisms in allograft rejection
8. T cell-mediated xenograft rejection: Specific tolerance is probably required for long term xenograft survival
9. Porcine aortic endothelial cells activate human T cells: Direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28
10. Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2
11. Human anti-porcine xenogeneic T cell response: Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition
12. Cellular xenoresponses: Observation of significant primary indirect human T cell anti-pig xenoresponses using co-stimulator-deficient or SLA class II-negative porcine stimulators
13. Porcine vascular cell adhesion molecule (VCAM) mediates endothelial cell adhesion to human T cells
14. Molecular and functional analysis of porcine E-selectin reveals a potential role in xenograft rejection
15. Effect of human inflammatory cytokines on porcine endothelial cell MHC molecule expression: Unique role for TNF-α in MHC class-II induction
16. Effect of human cytokines (IFN-γ, TNF-α, IL-1β, IL-4) on porcine endothelial cells: Induction of MHC and adhesion molecules and functional significance of these changes
17. Structure/function characterization of porcine CD59
18. Pig but not human interferon-γ initiates human cell-mediated rejection of pig tissue in vivo
19. Human TNF can induce nonspecific inflammatory and human immune-mediated microvascular injury of pig skin xenografts in immunodeficient mouse hosts
20. Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse
21. Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras
22. Dermal microvascular injury in the human peripheral blood lymphocyte reconstituted-severe combined immunodeficient (HuPBL-SCID) mouse/skin allograft model is T cell mediated and inhibited by a combination of cyclosporine and rapamycin
23. Human allogeneic vascular rejection after arterial transplantation and peripheral lymphoid reconstitution in severe combined immunodeficient mice
24. Transplantation models in human/mouse chimeras
25. Interferon-γ elicits arteriosclerosis in the absence of leukocytes
26. Immunosuppression with FK506 in rat arterial allografts: Fate of allogeneic endothelial cells
27. Transplant arterial vasculopathy: Evidence for a dual pattern of endothelial injury and the source of smooth muscle cells in lesions of intimal hyperplasia
28. Chronic allograft rejection associated vasculopathy and synthetic biodegradable vascular grafts: A lesson to learn?
29. Lymphokine dependence of in vivo expression of MHC class II antigens by endothelium
30. The unique role of interferon-γ in the regulation of MHC expression on arterial endothelium
31. Expression of vascular cell adhesion molecule-1 by vascular endothelial cells in immune and nonimmune inflammatory reactions in the skin
32. Cloning and expression kinetics of porcine vascular cell adhesion molecule
33. The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: Implications for xenotransplantation
34. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
35. Porcine endothelial CD86 is a major costimulator of xenogeneic human T cells
36. Human cell-mediated rejection of porcine xenografts in an immunodeficient mouse model
37. + T cells mediate rejection of porcine xenografts
38. + helper T cells and self antigen-presenting cells in the mouse
39. The potential role of xenogeneic antigen-presenting cells in T-cell co-stimulation
40. Direct and indirect activation of human T cells are important in discordant xenografts
41. Cellular basis of the proliferative response of human T cells to mouse xenoantigens
42. Evidence that multiple defects in cell-surface molecule interactions across species differences are responsible for diminished xenogeneic T cell responses