The nature of the peptide/ MHC ligand involved in positive selection

Seminars in Immunology

Volumn 8, Issue 2, 1996, Pages 63-68

  Hogquist, Kristin A ^a,b   Bevan, Michael J ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Agonist; Antagonist; Thymus

Indexed keywords

LIGAND; T LYMPHOCYTE RECEPTOR;

MAJOR HISTOCOMPATIBILITY COMPLEX; SHORT SURVEY; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ANIMALS; HUMANS; LIGANDS; MAJOR HISTOCOMPATIBILITY COMPLEX; PEPTIDES; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0029979256     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1996.0009     Document Type: Article

References (31)

1. Kisielow P, von Boehmer H (1995) Development and selection of T cells: Facts and puzzles. Adv Immunol 58:87-207
2. Marrack P, Kappler J (1987) The T cell receptor. Science 238:1073-1080
3. Nelson AJ, Hosier S, Brady W, Linsley PW, Farr AG (1993) Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro. J Immunol 151:2453-2461
4. + thymocytes. J Immunol 152:3254-3263
5. Anderson G, Jenkinson EJ, Moore NC, Owen JJ (1993) MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 362:70-73
6. + thymocytes in vitro. J Exp Med 179
7. Bonomo A, Matzinger P (1993) Thymus epithelium induces tissue-specific tolerance. J Exp Med 177:1153-1164
8. Vukmanovi'c S, Stella G, King PD, et al (1994) A positively selecting thymic epithelial cell line lacks costimulatory activity. J Immunol 152:3814-3823
9. Iwabuchi K, Nakayama K, McCoy RL, et al (1992) Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes. Proc Natl Acad Sci USA 89:9000-9004
10. Marrack P, Ignatowicz L, Kappler JW, Boymel J, Freed JH (1993) Comparison of peptides bound to spleen and thymus class II. J Exp Med 178:2173-2183
11. Robey E, Fowlkes BJ (1994) Selective events in T cell development. Annu Rev Immunol 12:675-705
12. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR (1994) T cell receptor antagonist peptides induce positive selection. Cell 76:17-27
13. Ashton-Rickardt PG, Bandeira A, Delaney JR, et al (1994) Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651-663
14. Sebzda E, Wallace VA, Mayer J, Yeung RSM, Mak TW, Ohashi PS (1994) Positive and negative thymocyte selection induced by different concentration of a single peptide. Science 263:1615-1618
15. Hogquist KA, Jameson SC, Bevan MJ (1994) The ligand for positive selection of T lymphocytes in the thymus. Curr Opin Immunol 6:273-278
16. Nikoli'c Zugi'c J, Bevan MJ (1990) Role of self-peptides in positively selecting the T-cell repertoire. Nature 344:65-67
17. Sha WC, Nelson CA, Newberry RD, et al (1990) Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding. Proc Natl Acad Sci USA 87:6186-6190
18. Jacobs H, von Boehmer H, Melief CJ, Berns A (1990) Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells. Eur J Immunol 20:2333-2337
19. Hogquist KA, Gavin MA, Bevan MJ (1993) Positive selection of CD8 + T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J Exp Med 177:1469-1473
20. van Santen HM, Woolsey A, Ashton Rickardt PG, et al (1995) Increase in positive selection of CD8 + T cells in TAP1-mutant mice by human b2-microglobulin transgene. J Exp Med 181:787-792
21. Schumacher TNM, Ploegh HL (1994) Are MHC-bound peptides a nuisance for positive selection? Immunity 1:721-723
22. Bevan MJ, Hogquist KA, Jameson SC (1994) Selecting the T cell receptor repertoire. Science 264:796-797
23. Tourne S, Nakano N, Viville S, Benoist C, Mathis D (1995) The influence of invariant chain on the positive selection of single T cell receptor specificities. Eur J Immunol 25:1851-1856
24. Hogquist KA, Jameson SC, Bevan MJ (1995) Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8 + T cells. Immunity 3:79-86
25. Jameson SC, Hogquist KA, Bevan MJ (1994) Specificity and flexibility in thymic selection. Nature 369:750-752
26. Robey EA, Ransdell F, Kioussis D, Sha W, Loh D, Axel R, Fowlkes BJ (1992) The level of CD8 expression can determine the outcome of thymic selection. Cell 69:1089-1095
27. Lee NA, Loh DY, Lacy E (1992) CD8 surface levels alter the fate of alpha/beta T cell receptor-expression thymocytesin transgenic mice. J Exp Med 175:1013-1019
28. Tarakhovsky A, Kanner SB, Homback J, Ledbetter JA, Muller W, Kileen N, Rajewsky K (1995) A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269:535-537
29. Sloan-Lancaster J, Shaw AS, Rothbard JB, Allen PM (1994) Partial T cell signaling: altered phospho-zeta and lack of ZAP-70 recruitment in APL-induced T cell anergy. Cell 79:913-922
30. Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN (1995) Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515-518
31. Germain RN, Levine EH, Madrenas J (1995) The T-cell receptor as a diverse signal transduction machine. The Immunologist 3:113-121