Complexities in the neurotoxic actions of 6-hydroxydopamine in relation to the cytoprotective properties of taurine

Brain Research Bulletin

Volumn 55, Issue 2, 2001, Pages 239-245

  Hayes, James ^a   Tipton, Keith F ^a   Bianchi, Loria ^b   Corte, Laura Della ^b,c  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF FLORENCE   (Italy)

^c Department of Preclinical and Clinical Pharmacology ^*  (Italy)

Author keywords

Aconitase; GABA; Glyceraldehyde 3 phosphate dehydrogenase; Iron release; Microdialysis; Sulphydryl groups

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ACONITATE HYDRATASE; FERRIC ION; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; KAINIC ACID; NEUROTOXIN; OXIDOPAMINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TAURINE; THIOL GROUP;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; BRAIN DEPTH STIMULATION; BRAIN MITOCHONDRION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GLOBUS PALLIDUS; IC 50; IRON KINETICS; MALE; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

ACONITATE HYDRATASE; ADRENERGIC AGENTS; ANIMALS; DOPAMINE; EXTRACELLULAR SPACE; GAMMA-AMINOBUTYRIC ACID; GLOBUS PALLIDUS; IRON; KAINIC ACID; MALE; MICRODIALYSIS; NEOSTRIATUM; NEURAL PATHWAYS; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; OXIDATION-REDUCTION; OXIDOPAMINE; PARKINSON DISEASE; PRESYNAPTIC TERMINALS; RATS; RATS, WISTAR; SUBSTANTIA NIGRA; SULFHYDRYL COMPOUNDS; TAURINE;

EID: 0035872425     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(01)00507-X     Document Type: Conference Paper

References (66)

1. The determination of hydroxydopamines and other trace amines in the urine of parkinsonian patients and normal controls
2. The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons
3. The release of amino acids from rat neostriatum and substantia nigra in vivo: A dual microdialysis probe analysis
4. Simultaneous determination of basal and evoked output levels of aspartate, glutamate, taurine and 4-aminobutyric acid during microdialysis and from superfused brain slices
5. The effect of kainic acid on the release of GABA in rat neostriatum and substantia nigra
6. Carnosine and taurine protect rat cerebellar granular cells from free radical damage
7. Free radicals and the pathobiology of brain dopamine systems
8. Vitamin E attenuates the toxicity of intranigral injection of 6-hydroxdopamine (6-OHDA): Behavioral and biochemical evidence
9. Iron-responsive elements: Regulatory RNA sequences that control mRNA levels and translation
10. Monoamine oxidase, hydrogen peroxide and Parkinson's disease
11. Destruction of sympathetic nerve terminals by 6-hydroxydopamine: Protection by L-phenyl-3-(2-thiazolyl)-2-thiourea, diethyldithiocarbamate, methimazole, cysteamine, ethanol and n-butanol
12. Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress
13. 3H]taurine in the rat substantia nigra in relation to the release of taurine from the striatonigral pathway
14. Primate models of movement disorders of basal ganglia origin
15. Oxidative stress to rat lens in vitro: Protection by taurine
16. Levels of iron, ferritin and other trace elements in Parkinson's disease and in other neurodegenerative diseases affecting the basal ganglia
17. In vitro studies of ferritin iron release and neurotoxicity
18. Tissue sulphydryl groups
19. Inactivation of both RNA binding and aconitase activities of ion response element-binding protein 1 by quinone induced oxidative stress
20. Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine
21. Nature of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine
22. Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine
23. Pronounced formation of 5-OH-dopa at enzymatic oxidation of DOPA in the presence of ascorbic acid
24. Enhancing effect of taurine in the rat caudate spindle. II. Effect of bilateral 6-hydroxydopamine lesions of the nigro-striatal dopamine system
25. The stability of 6-hydroxydopamine under minipump conditions
26. Physiological actions of taurine
27. Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease
28. Dopamine-induced apoptosis is mediated by oxidative stress and is enhanced by cyanide in differentiated PC12 cells
29. Effects of 6-hydroxdopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons
30. The state of cluster SH and S2- of aconitase during cluster interconversions and removal. A convenient preparation of apoenzyme
31. The role of iron in the activation-inactivation of aconitase
32. Oxygen activation during the interaction between MPTP metabolites and synthetic neuromelanin - An ESR-spin trapping, optical, and oxidase electrode study
33. Osmotic regulation of the heat shock response in primary rat hepatocytes
34. Release of iron from ferritin by 6-hydroxydopamine under aerobic and anaerobic conditions
35. 2+ uptake in synaptosomal and mitochondrial subcellular fractions of rat retina
36. NMDA-, kainate- and quisqualate-stimulated release of taurine from electrophysiologically monitored rat hippocampal slices
37. Degeneration of adrenergic nerves produced by 6-hydroxdopamine
38. The mechanisms of taurine mediated protection against cell damage induced by hypoxia and reoxygenation
39. Changes of amino acid and monoamine levels after neonatal 6-hydroxydopamine denervation in rat basal ganglia, substantia nigra, and Raphe nuclei
40. 6-Hydroxydopamine releases iron from ferritin and promotes ferritin dependent lipid-peroxidation
41. Evidence of a direct action of taurine and calcium on biological membranes. A combined study of 31P-nuclear magnetic resonance and electron spin resonance
42. 2 oxidation of dopamine
43. The effects of glutathione and ascorbic acid on the oxidations of 6-hydroxydopa and 6-hydroxydopamine
44. + neurotoxicity in vitro: A possible role for the GABA(A) subclass of GABA receptors
45. Degeneration of nigrostriatial dopaminergic neurons increases iron within the substantia nigra: A histochemical and neurochemical study
46. 2+ sequestration by taurine
47. Regional effects of 6-hydroxdopamine (6-OHDA) on free radical scavengers in rat brain
48. Iron mediated generation of the neurotoxin 6-OHDA quinone by reaction of fatty acid hydroxides with dopamine. A possible contributory mechanism for neuronal degeneration in Parkinson's disease
49. Studies on the autoxidation of dopamine: Interaction with ascorbate
50. Model experiments on the molecular mechanism of action of 6-hydrozdopamine
51. Enhanced taurine release in cell-damaging conditions in the developing and ageing mouse hippocampus
52. Subcellular distribution of GAPDH in cerebellar granule cells undergoing cytosine arabinoside induced apoptosis
53. Taurine improves the recovery of neuronal function following cerebral hypoxia: An in vitro study
54. Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: An electron paramagnetic resonance spectroscopy study
55. New insights into an old protein: The functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase
56. Comparison of some pharmacologic effects of certain 6-substituted dopamine derivatives with reserpine, guanethidine and metaraminol
57. Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxdopamine
58. The in vivo and in vitro protective properties of taurine
59. Patterns of enzyme inhibition
60. Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
61. Cellular and subcellular redistribution of glutamate-, glutamine-, and taurine-like immunoreactivities during forebrain ischemia: A semiquantitative electron microscopic study in rat hippocampus
62. Ascorbic acid enhances ferritin mRNA translation by an IRP/aconitase switch
63. A possible role for taurine in osmoregulation within the brain
64. +, apoptosis induced by 6-OHDA in PC12 cells is independent of mitochondrial inhibition