EGR-1, a UV-inducible gene in p53-/- mouse cells

Experimental Cell Research

Volumn 266, Issue 1, 2001, Pages 21-30

  Zhang, Weihua ^a   Chen, Suzie ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR; PROTEIN P53; SURAMIN;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; DNA SEQUENCE; EARLY RESPONSE GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE OVEREXPRESSION; IMMEDIATE EARLY GENE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; ULTRAVIOLET RADIATION;

MAMMALIA;

EID: 0035872235     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5196     Document Type: Article

References (36)

1. Ultraviolet radiation-induced skin cancer
2. Three distinct signalling responses by murine fibroblasts to genotoxic stress
3. Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN
4. Cancer: A deadly inheritance
5. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
6. Relationships between Plasmodium falciparum infection and morbidity in a highly endemic area
7. Induction of apoptosis by wild-type p53 in a huma colon tumor-derived cell line
8. Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6
9. WAF1, a potential mediator of p53 tumor suppression
10. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
11. A subset of p53-deficient embryos exhibit exencephaly
12. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
13. Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells
14. p53-independent induction of WAF1/Cip1 is correlated with osteoblastic differentiation by vitamin D3
15. p53-independent induction of p21 (WAF1/CIP1) during differentiation of HL-60 cells by tumor necrosis factor alpha
16. Excess wild-type p53 blocks initiation and maintenance of simian virus 40 transformation
17. p53-dependent response in UV-induced transformation
18. Reporter system using chloramphemical acetyltransferase
19. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences
20. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells
21. Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin
22. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
23. Egr-1-induced endothelial gene expression: A common theme in vascular injury
24. The zinc finger transcription factor Egr-1 potentiates macrophage differentiation of hematopoietic cells
25. The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor
26. Control of cell cycle progression by c-Jun is p53 dependent
27. Early growth response protein 1 (Egr-1): Prototype of a zinc-finger family of transcription factors
28. Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24: Evidence for a common regulatory pathway for immediate-early serum-response genes
29. Involvement of growth factor receptors in the mammalian UVC response
30. Identification of MAP kinase domains by redirecting stress signals into growth factor responses
31. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
32. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap 1-dependent pathway
33. Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product
34. Wildtype p53 can down-modulate the activity of various promoters
35. EGR-1, the reluctant suppression factor: EGR-1 is known to function in the regulation of growth, differentiation, and also has significant tumor suppressor activity and a mechanism involving the induction of TGF-beta1 is postulated to account for this suppressor activity