Alternative splicing at the 3'-cDNA of human tryptophan hydroxylase

Journal of Neurochemistry

Volumn 71, Issue 4, 1998, Pages 1769-1772

  Wang, Guo An ^a   Coon, Steven L ^b   Kaufman, Seymour ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Alternative splicing; Human brain; Regulation; Serotonin; Tryptophan hydroxylase

Indexed keywords

COMPLEMENTARY DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; TRYPTOPHAN HYDROXYLASE;

ALTERNATIVE RNA SPLICING; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; DNA DETERMINATION; ENZYME ISOLATION; GENE SEQUENCE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

EID: 0031712380     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71041769.x     Document Type: Article

References (22)

1. Banik U., Wang G. A., Wagner P. D., and Kaufman S. (1997) Interaction of phosphorylated tryptophan hydroxylase with 14-3-3 proteins. J. Biol. Chem. 272, 26219-26225.
2. 6,2′-O-dibutyryladenosine 3′:5′-cyclic monophosphate. Biochem. Pharmacol. 29, 669-672.
3. Boularand S., Darmon M. C., Ganem Y., Launay J. M., and Mallet J. (1990) Complete coding sequence of human tryptophan hydroxylase. Nucleic Acids Res. 18, 4257.
4. Boularand S., Darmon M. C., and Mallet J. (1995) The human tryptophan hydroxylase gene. An unusual splicing complexity in the 5′-untranslated region. J. Biol. Chem. 270, 3748-3756.
5. Craig S. P., Boularand S., Darmon M. C., Mallet J., and Craig I. W. (1991) Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3-p14 by in situ hybridization. Cytogenet. Cell Genet. 56, 157-159.
6. Darmon M. C., Guibert B., Leviel V., Ehret M., Maitre M., and Mallet J. (1988) Sequence of two mRNAs encoding active rat tryptophan hydroxylase. J. Neurochem. 51, 312-316.
7. Dumas S., Darmon M. C., Delort J., and Mallet J. (1989) Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: evidence for a role of translation efficiency. J. Neurosci. Res. 24, 537-547.
8. Goodwill K. E., Sabatier C., Marks C., Raag R., Fitzpatrick P. F., and Stevens R. C. (1997) Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases. Nat. Struct. Biol. 4, 578-585.
9. Grahame-Smith D. G. (1967) The biosynthesis of 5-hydroxytryptamine in brain. Biochem. J. 105, 351-360.
10. Grenett H. E., Ledley F. D., Reed L. L., and Woo S. L. (1987) Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases. Proc. Natl. Acad. Sci. USA 84, 5530-5534.
11. Hufton S. E., Jennings I. G., and Cotton R. G. H. (1995) Structure and function of the aromatic amino acid hydroxylase. Biochem. J. 311, 353-366.
12. Ichimura T., Uchiyama J., Kunihiro O., Ito M., Horigome T., Omata S., Shinkai F., Kaji H., and Isobe T. (1995) Identification of the site of interaction of the 14-3-3 protein with phosphorylated tryptophan hydroxylase. J. Biol. Chem. 270, 28515-28518.
13. Jacobs B. L., and Azmitia E. C. (1992) Structure and function of brain serotonin system. Physiol. Rev. 72, 165-229.
14. Jequier E., Lovenberg W., and Sjoerdsma A. (1967) Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin. Mol. Pharmacol. 3, 274-278.
15. Kappock T. J. and Caradonna J. P. (1996) Pterin-dependent amino acid hydroxylases. Chem. Rev. 96, 2659-2756.
16. Kim K. S., Wessel T. C., Stone D. M., Carver C. H., Joh T. H., and Park D. H. (1991) Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons. Brain Res. Mol. Brain Res. 9, 277-283.
17. Kuhn D. M., Arthur R. Jr., and States J. C. (1997) Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A. J. Neurochem. 68, 2220-2223.
18. Lovenberg W. (1977) The enzymology of tryptophan hydroxylase, in Structure and Function of Monoamine Enzymes (Usdin E., Weiner N., and Youdim M. B. H., eds), pp. 43-58. Marcel Dekker, New York.
19. Mockus S. M., Kumer S. C., and Vrana K. E. (1997) Carboxyl terminal deletion analysis of tryptophan hydroxylase. Biochim. Biophys. Acta 1342, 132-140.
20. Molliver M. E. (1987) Serotonergic neuronal systems: what their anatomic organization tells us about function. J. Clin. Psychopharmacol. 7, 3S-23S.
21. Steward O. (1997) mRNA localization in neurons: a multipurpose mechanism? Neuron 18, 9-12.
22. Tipper J. P., Citron B. A., Ribeiro P., and Kaufman S. (1994) Cloning and expression of rabbit and human brain tryptophan hydroxylase cDNA in Escherichia coli. Arch. Biochem. Biophys. 315, 445-453.