Inability to produce IL-6 is a functional feature of human germinal center B lymphocytes

Journal of Immunology

Volumn 156, Issue 11, 1996, Pages 4107-4113

  Burdin, Nicolas ^a,b   Galibert, Laurent ^a,b   Garrone, Pierre ^a   Durand, Isabelle ^a   Banchereau, Jacques ^a   Rousset, Françoise ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Fondation Merieux   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CELL RECEPTOR; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA; PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL GROWTH; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSCRIPTION; GERMINAL CENTER; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTILYMPHOCYTE SERUM; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; BASE SEQUENCE; CD40 LIGAND; CELL DIFFERENTIATION; DNA PRIMERS; GERMINAL CENTER; HUMANS; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; PHENOTYPE; RECEPTORS, ANTIGEN, B-CELL; RNA, MESSENGER; STAPHYLOCOCCUS AUREUS; TONSIL; TRANSCRIPTION, GENETIC;

EID: 0029934449     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Banchereau, J., F. Bazan, D. Blanchard, F. Brière, J. P. Galizzi, C. Van Kooten, Y. J. Liu, F. Rousset, and S. Saeland. 1994. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12:881.
2. Kroese, F. G., W. Timens, and P. Nieuwenhuis. 1990. Germinal center reaction and B lymphocytes: morphology and function. Curr. Top. Pathol. 84:103.
3. Kosco, M. H., and D. Gray. 1992. Signals involved in germinal center reactions. Immunol. Rev. 126:63.
4. MacLennan, I. C. 1994. Germinal centers. Annu. Rev. Immunol. 12:117.
5. Lagresle, C., C. Bella, and T. Defrance. 1993. Phenotypic and functional heterogeneity of the IgD- B cell compartment: identification of two major tonsillar B cell subsets. Int. Immunol. 5:1259.
6. Liu, Y. J., C. Barthelemy, O. de Bouteiller, C. Arpin, I. Durand, and I. Banchereau. 1995. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 2:239.
7. Liu, Y. J., and J. Banchereau. 1996. Human peripheral B cells subsets. In Handbook of Experimental Immunology. D. Weir, C. Blackwell, and L. Hersenberg, eds. Blackwell Scientific Publications, Oxford, U.K. In press.
8. Pascual, V., Y. J. Liu, A. Magalski, O. de Bouteiller, J. Banchereau, and J. D. Capra. 1994. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180:329.
9. Parker, D. C. 1993. T cell-dependent B cell activation. Annu. Rev. Immunol. 11:331.
10. Clark, E. A., and J. A. Ledbetter. 1994. How B and T cells talk to each other. Nature 367:425.
11. Banchereau, J., and F. Rousset. 1992. Human B lymphocytes: phenotype, proliferation, and differentiation. Adv. Immunol. 52:125.
12. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Nature 314:537.
13. Burdin, N., C. Van Kooten, L. Galibert, J. S. Abrams, J. Wijdenes, J. Banchereau, and F. Rousset. 1995. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J. Immunol. 154:2533.
14. Matthes, T., F. C. Werner, H. Tang, X. Zhang, V. Kindler, and R. H. Zubler. 1993. Cytokine mRNA expression during an in vitro response of human B lymphocytes: kinetics of B cell tumor necrosis factor alpha, interleukin (IL) 6, IL-10, and transforming growth factor beta 1 mRNAs. J. Exp. Med. 178:521.
15. Rieckmann, P., F. D'Alessandro, R. P. Nordan, A. S. Fauci, and J. H. Kehrl. 1991. IL-6 and tumor necrosis factor alpha: autocrine and paracrine cytokines involved in B cell function. J. Immunol. 146:3462.
16. Sung, S. S., L. K. Jung, J. A. Walters, E. Jeffes, G. A. Granger, and S. M. Fu. 1989. Production of lymphotoxin by isolated human tonsillar B lymphocytes and B lymphocyte cell lines. J. Clin. Invest. 84:236.
17. Hawrylowicz, C. M., L. M. Duncan, R. C. Fuhlbridge, and E. R. Unanue. 1989. Regulation of antigen presentation. II. Anti-Ig and IL-2 induce IL-1 production by murine splenic B cells. J. Immunol. 142:3361.
18. Houssiau, F., P. G. Coulie, D. Olive, and J. Van Snick. 1988. Synergistic activation of human T cells by interleukin-1 and interleukin-6. Eur. J. Immunol. 18:653.
19. Scheurich, P., B. Thoma, U. Ucer, and K. Pfizenmaier. 1987. Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-α: induction of TNF receptors on human T cells and TNF-α-mediated enhancement of T cell responses. J. Immunol. 138:1786.
20. Cerwenka, A., D. Bevec, O. Majdic, W. Knapp, and W. Holter 1994. TGFβ1 is a potent inducer of human effector T cells. J. Immunol. 153:4367.
21. Ford, R. J., A. Tamayo, and J. L. Ambrus, Jr. 1992. The role of growth factors in human lymphomas. Curr. Top. Microbiol. Immunol. 182:341.
22. Van Kooten, C., and J. Banchereau. 1996. CD40-CD40 ligand, a multifunctional receptor-ligand pair. Adv. Immunol. 61:1.
23. Abrams, J. S., M. G. Roncarolo, H. Yssel, U. Andersson, G. J. Gleich, and J. E. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5.
24. Yssel, H., J. E. De Vries, M. Koken, W. Van Blitterswijk, and H. Spits. 1984. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J. Immunol. Methods 72:219.
25. Clark, E. A., and G. Shu. 1990. Association between IL-6 and CD40 signaling. IL-6 induces phosphorylation of CD40 receptors. J. Immunol. 145:1400.
26. Galibert, L., N. Burdin, B. De Saint-Vis, P. Garrone, C. Van-Kooten, J. Banchereau, and F. Rousset. 1996. CD40 and BCR dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. J. Exp. Med. 183:77.
27. Galibert, L., I. Durand, J. Banchereau, and F. Rousset. 1994. CD40-activated surface IgD-positive lymphocytes constitute the long term IL-4-dependent proliferating B cell pool. J. Immunol. 152:7.
28. Hibi, M., M. Murakami, M. Saito, T. Hirano, T. Taga, and T. Kishimoto. 1990. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63: 1149.
29. Saito, M., K. Yoshida, M. Hibi, T. Taga, and T. Kishimoto. 1992. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J. Immunol. 148:4066.
30. Chintagumpala, M. M., J. A. Mollick, and R. R. Rich. 1991. Staphylococcal toxins bind to different sites on HLA-DR. J. Immunol. 147:3876.
31. Marrack, P., and J. Kappler. 1990. The Staphylococcal enterotoxins and their relatives. Science 248:1335.
32. Hirata, Y., T. Taga, M. Hibi, N. Nakano, T. Hirano, and T. Kishimoto. 1989. Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies. J. Immunol. 143:2900.
33. Taga, T., Y. Kawanishi, R. R. Hardy, T. Hirano, and T. Kishimoto. 1987. Receptors for B cell stimulatory factor 2: quantitation, specificity, distribution, and regulation of their expression. J. Exp. Med. 166:967.
34. Levy, Y., J. P. Fernand, and J. C. Brouet. 1990. Differential effects of low and high concentrations of interleukin-6 on human B cells. Eur. J. Immunol. 20:2389.
35. Liu, Y. J., C. Barthelemy, O. de Bouteiller, and J. Banchereau. 1994. The differences in survival and phenotype between centroblasts and centrocytes. Adv. Exp. Med. Biol. 355:213.
36. Clark, E. A., K. H. Grabstein, and G. L. Shu. 1992. Cultured human follicular dendritic cells: growth characteristics and interactions with B lymphocytes. J. Immunol. 148:3327.
37. Kosco-Vilbois, M. H., and D. Scheidegger. 1995. Follicular dendritic cells: antigen retention, B cell activation, and cytokine production. Curr. Top. Microbiol. Immunol. 201:69.
38. Orscheschek, K., H. Merz, B. Schlegelberger, and A. C. Feller. 1994. An immortalized cell line with features of human follicular dendritic cells: antigen and cytokine expression analysis. Eur. J. Immunol. 24:2682.
39. Grouard, G., O. de Bouteiller, J. Banchereau, and Y.-J. Liu. 1995. Human follicular dendritic celts enhance cytokine dependent growth and differentiation of CD40 activated B cells J. Immunol. 155:3345.
40. Liu, Y. J., G, Grouard, O. de-Bouteiller, and J. Banchereau. 1996. Follicular dendritic cells and germinal centers. Int. Rev. Cytol. 166:139.
41. Akira, S., T. Taga, and T. Kishimoto. 1993. Interleukin-6 in biology and medicine. Adv. Immunol. 54:1.
42. Bosseloir, A., P. E. Hooghe, E. Heinen, N. Cormann, D. C. Kinet, L. Vanhaelst, and L. Simar. 1989. Localization of interleukin 6 mRNA in human tonsils by in situ hybridization. Eur. J. Immunol. 19:2379.
43. Andersson, J., J. Abrams, L. Björk, K. Funa, M. Litton, K. Agren, and U. Andersson. 1994. Concomitant in vivo production of 19 different cytokines in human tonsils. Immunology 83:16.
44. Kopf, M., H. Baumann, G. Freer, M. Freudenberg, M. Lamers, T. Kishimoto, R. Zinkernagel, H. Bluethmann, and G. Kohler. 1994. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368:339.
45. Yoshizaki, K., T. Matsuda, N. Nishimoto, T. Kuritani, L. Taeho, K. Aozasa, T. Nakahata, H. Kawai, H. Tagoh, T. Komori, S. Kishimoto, T. Hirano, and T. Kishimoto. 1989. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74:1360.
46. Leger-Ravet, M. B., M. Peuchmaur, O. Devergne, J. Audouin, M. Raphael, J. Van Damme, P. Galanaud, J. Diebold, and D. Emilie. 1991. Interleukin-6 gene expression in Castleman's disease. Blood 78:2923.
47. Brandt, S. J., D. M. Bodine, C. E. Dunbar, and A. W. Nienhuis. 1990. Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J. Clin. Invest. 86:592.
48. Corcione, A., L. Baldi, S. Zupo, M. Dono, G. B. Rinaldi, S. Roncella, G. Taborelli, M. Truini, M. Ferrarini, and V. Pistoia. 1994. Spontaneous production of granulocyte colony-stimulating factor in vitro by human B-lineage lymphocytes is a distinctive marker of germinal center cells. J. Immunol. 153:2868.