Single nucleotide instability without microsatellite instability in rat mammary carcinomas

Cancer Research

Volumn 61, Issue 6, 2001, Pages 2632-2640

  Watanabe, Naoko ^a,b   Okochi, Eriko ^a   Hirayama, Yoshikazu ^a   Shimada, Yoshiya ^c   Yanagihara, Kazuyoshi ^a   Yoshida, Michihiro C ^d   Takahashi, Satoru ^e   Mochizuki, Masataka ^b   Sugimura, Takashi ^a   Nagao, Minako ^a   Ushijima, Toshikazu ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

^e NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE;

ANIMAL CELL; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER CELL CULTURE; CONTROLLED STUDY; FEMALE; GENE MUTATION; MICROSATELLITE INSTABILITY; MUTATION RATE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RAT; TRANSGENE;

ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; CARCINOGENS; DNA MUTATIONAL ANALYSIS; ESCHERICHIA COLI PROTEINS; FEMALE; GENES, P53; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IMIDAZOLES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; TRANSGENES; TUMOR CELLS, CULTURED;

EID: 0035866776     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Mutator phenotype may be required for multistage carcinogenesis
2. The mutation rate and cancer
3. Genetic instabilities in human cancers
4. Microsatellite instability: The mutator that mutates the other mutator
5. Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer
6. Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype
7. Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects
8. Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice
9. Increased transversions in a novel mutator colon cancer cell line
10. Transgenic systems for in vivo mutation analysis
11. The lacI gene as a target for mutation in transgenic rodents and Escherichia coli
12. Microsatellite instability and loss of heterozygosity on chromosome 10 in rat mammary tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
13. Microsatellite instability is uncommon in breast cancer
14. Preferential induction of guanine deletion at 5′-GGGA-3′ in rat mammary glands by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
15. Effects of maturational agents on expression and secretion of two partially characterized high molecular weight milk-related glycoproteins in MCF-7 breast carcinoma cells
16. Differentiation of cultured human breast cancer cells (AU-565 and MCF-7) associated with loss of cell surface HER-2/neu antigen
17. Establishment of hormone-dependent and hormone-independent carcinoma cell lines with different metastatic potentials from spontaneous mammary tumors in aged Wistar rats
18. Primary culture of flow cytometry-sorted rat mammary epithelial cell (RMEC) subpopulations in a reconstituted basement membrane, Matrigel
19. Isolation of high-molecular-weight DNA from mammalian cells
20. Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice
21. Mutations of bacteria from virus sensitivity to virus resistance
22. A rapid method for detection of mutations in the lacI gene using PCR-single strand conformation polymorphism analysis: Demonstration of its high sensitivity
23. Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa
24. Rare mutations of p53, Ki-ras, and β-catenin genes and absence of K-sam and c-erbB-2 amplification in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach cancers
25. Specific 5′-GGGA-3′→5′-GGA-3′ mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
26. Cancer cells exhibit a mutator phenotype
27. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis
28. Counteraction by MutT protein of transcriptional errors caused by oxidative damage
29. The fidelity of DNA polymerase β during distributive and processive DNA synthesis
30. DNA-replication fidelity, mismatch repair, and genome instability in cancer cells
31. Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in colon cancer cell lines defective in mismatch repair
32. Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53/Big Blue double transgenic mice
33. Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage λ transgene target
34. Evidence of genetic progression in human gastric carcinomas with microsatellite instability
35. Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice
36. p53 deficiency does not affect the accumulation of point mutations in a transgene target