Gene expression profiling of malignant mesothelioma cell lines: cDNA array study

International Journal of Cancer

Volumn 91, Issue 4, 2001, Pages 492-496

  Kettunen, Eeva ^a,b   Nissn, Anna Maria ^c   Ollikainen, Tiina ^a,c   Taavitsainen, Matti ^a   Tapper, Johanna ^a   Mattson, Karin ^a   Linnainmaa, Kaija ^a   Knuutila, Sakari ^a   El Rifai, Wael ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

cDNA array; Gene expression; Malignant mesothelioma; Mesothelial cell; RT PCR

Indexed keywords

CELL PROTEIN; COMPLEMENTARY DNA; CYCLIN D2; GROWTH FACTOR; JAGGED1; PROTEIN; PROTEIN KU80; PROTEIN SERINE THREONINE KINASE; RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL CYCLE; CELL FATE; CELL GROWTH; CELL INVASION; CELL MOTILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; DNA REPAIR; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MALE; MALIGNANT MESOTHELIOMA; MESOTHELIUM CELL; NUCLEOTIDE SEQUENCE; PLEURA FLUID; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

DNA, COMPLEMENTARY; DOWN-REGULATION; ELECTROPHORESIS, AGAR GEL; EPITHELIUM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MESOTHELIOMA; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0035866041     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(200002)9999:9999<::AID-IJC1094>3.0.CO;2-M     Document Type: Article

References (52)

1. Use of cDNA microarray to analyse gene expression patterns in human cancer
2. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
3. Malignant mesothelioma of the pleura: Review of 123 patients
4. Simian virus 40-like DNA sequences in human pleural mesothelioma
5. Molecular biology studies on mesothelioma tumor samples: Preliminary data on H-ras, p21, and SV40
6. The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas
7. A multi-institutional study confirms the presence and expression of simian virus 40 in human malignant mesotheliomas
8. Inherited GSTM1 and NAT2 as concurrent risk modifiers in asbestos-related human malignant mesothelioma
9. Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders
10. Diffuse pleural mesotheliomas and asbestos exposure in the Northwestern Cape Province
11. DNA copy number amplifications in human neoplasms - Review of comparative genomic hybridization studies
12. DNA copy number losses in human neoplasms
13. High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesothelioma
14. Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: Evidence for a two-hit mechanism of NF2 inactivation
15. Heterogeneity of mesothelioma cell lines as defined by altered genomic structure and expression of the NF2 gene
16. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
17. Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesothelioma
18. Asbestos-related malignant mesothelioma: Growth, cytology, tumorigenicity and consistent chromosome findings in cell lines from five patients
19. Gains and losses of DNA sequences in malignant mesothelioma by comparative genomic hybridization
20. The role of growth factors and cytokines in the tumorigenesis and immunobiology of malignant mesothelioma
21. Comparison of production of transforming growth factor-β and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines
22. Tenascin and fibronectin expression in human mesothelial cells and pleural mesothelioma cell-line cells
23. Expression of c-sis (PDGF B-chain) and PDGF A-chain genes in ten human malignant mesothelioma cell lines derived from primary and metastatic tumors
24. Human malignant mesothelioma cell lines express PDGF beta-receptors whereas cultured normal mesothelial cells express predominantly PDGF alpha-receptors
25. Immunoreactivity for p53 and mdm2 and the detection of p53 mutations in human malignant mesothelioma
26. High levels of MDM2 are not correlated with the presence of wild-type p53 in human malignant mesothelioma cell lines
27. p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma
28. Codeletion of p15 and p16 in primary malignant mesothelioma
29. The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma
30. Complex structure and regulation of the p16 (MTS1) locus
31. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
32. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members
33. Rel/NF-κB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors
34. Human ligands of the Notch receptor
35. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
36. Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12
37. SARPs: A family of secreted apoptosis-related proteins
38. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins
39. Characterization of a candidate bcl-1 gene
40. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
41. Activation of cyclin D1 related kinase in human lung adenocarcinoma
42. D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1
43. Over-expression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development
44. Chromosomal abnormalities and their correlations with asbestos exposure and survival in patients with mesothelioma
45. Cdc25 cell-cycle phosphatase as a target of c-myc
46. Systematic variation in gene expression patterns in human cancer cell lines
47. Evaluation of the tumorigenic and angiogenic potential of human fibroblast growth factor FGF3 in nude mice
48. Ku autoantigen affects the susceptibility to anticancer drugs
49. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
50. 1 phase by contact inhibition and TGF-beta1 in mink Mv1Lu lung epithelial cells
51. Angiogenic cytokines in mesothelioma: A study of VEGF, FGF-1 and -2, and TGF beta expression