Mutation screening of the 5-hydroxytryptamine7 receptor gene among Finnish alcoholics and controls

Psychiatry Research

Volumn 77, Issue 3, 1998, Pages 139-145

  Pesonen, Ullamari ^a,b   Koulu, Markku ^a,b   Bergen, Andrew ^b   Eggert, Monica ^c   Naukkarinen, Hannu ^c   Virkkunen, Matti ^c   Linnoila, Markku ^d   Goldman, David ^b  

^a UNIVERSITY OF TURKU   (Finland)

^b Div Intramural Clin Biol Res N   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

^d Intramural Research Program   (United States)

Author keywords

Human; Impulsivity; Point mutation; Polymorphism; Receptors; Serotonin genetics

Indexed keywords

ALCOHOL; LEUCINE; PROLINE; SEROTONIN; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ALCOHOLISM; ARTICLE; BEHAVIOR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FINLAND; GENE FREQUENCY; GENE MUTATION; GENETIC SCREENING; HETEROZYGOSITY; HUMAN; MALE; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR GENE; RELATIVE; SEROTONINERGIC TRANSMISSION;

ADULT; ALCOHOLISM; ALLELES; AMINO ACID SUBSTITUTION; DNA MUTATIONAL ANALYSIS; FEMALE; FINLAND; GENE FREQUENCY; GENETIC SCREENING; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POINT MUTATION; POLYMORPHISM, GENETIC; RECEPTORS, SEROTONIN;

EID: 0032570998     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(98)00005-5     Document Type: Article

References (21)

1. 7) positively linked to adenylate cyclase. Journal of Biological Chemistry. 268:1993;23422-23426.
2. Cadoret R.J., O'Gorman T.W., Troughton E., Heywood E. Alcoholism and antisocial personality. Interrelationships, genetic and environmental factors. Archives of General Psychiatry. 42:1985;161-167.
3. Cloninger C.R., Bohman M., Sigvardsson S. Inheritance of alcohol abuse: cross-fostering analysis of adopted men. Archives of General Psychiatry. 38:1981;861-868.
4. 7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder. Molecular Psychiatry. 1:1996;392-397.
5. Franke R.R., Sakmar T.P., Oprian D.D., Khorana H.G. A single amino acid substitution in rhodopsin (lysine 248→leucine) prevents activation of transducin. Journal of Biological Chemistry. 263:1988;2119-2122.
6. 7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. Journal of Neurochemistry. 68:1997;1372-1381.
7. Higley J.D., Mehlman P.T., Taub D.M., Higley S.B., Suomi S.J., Vickers J.H., Linnoila M. Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Archives of General Psychiatry. 49:1992;436-441.
8. Higley J.D., Thompson W.W., Champoux M., Goldman D., Hasert M.F., Kraemer G.W., Scanlan J.M., Suomi S.J., Linnoila M. Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta). Archives of General Psychiatry. 50:1993;615-623.
9. Gelernter J., Rao P.A., Pauls D.L., Hamblin M.W., Sibley D.R., Kidd K.K. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome. Genomics. 26:1995;207-209.
10. Limson R., Goldman D., Roy A., Lamparski D., Ravitz B., Adinoff B., Linnoila M. Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Archives of General Psychiatry. 48:1991;437-441.
11. Linnoila M., DeJong J., Virkkunen M. Family history of alcoholism in violent offenders and impulsive fire setters. Archives of General Psychiatry. 46:1989;613-616.
12. 7) implicated in the regulation of mammalian circadian rhythms. Neuron. 11:1993;449-458.
13. 2 adrenergic receptor protein based on computer modeling studies. Genomics. 225:1992;859-871.
14. 2-adrenergic receptor. Journal of Biological Chemistry. 263:1988;15985-15992.
15. 2A receptor determines effects of coupling specificity. Neurochemistry. 64:1995;1440-1447.
16. 7 receptor gene found in alcoholics with antisocial personality disorder. Society for Neuroscience Abstracts 21, Part 2, 1121.
17. Roth B.L., Craigo S.C., Choudhary M.S., Uluer A., Monsma F.J. Jr., Shen Y., Meltzer H.Y., Sibley D.R. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. Journal of Pharmacology and Experimental Therapeutics. 268:1994;1403-1410.
18. 7 serotonin receptor subtype. Journal of Biological Chemistry. 268:1993;18200-18204.
19. 1A receptor synthetic peptides. Journal of Biological Chemistry. 269:1994;16720-16725.
20. Virkkunen M., Kallio E., Rawlings R., Tokola R., Poland R.E., Guidotti A., Nemeroff C., Bissette G., Kalogeras K., Karonen S.-L., Linnoila M. Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters and healthy volunteers. Archives of General Psychiatry. 51:1994;28-33.
21. Virkkunen M., Rawlings R., Tokola R., Poland R.E., Guidotti A., Nemeroff C., Bissette G., Kalogeras K., Karonen S.-L., Linnoila M. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters and healthy volunteers. Archives of General Psychiatry. 51:1994;20-27.